Formation of a border ischemic zone depends on plasma potassium concentration
Can J Physiol Pharmacol. 2023 Dec 20. doi: 10.1139/cjpp-2023-0304. Online ahead of print.ABSTRACTExtracellular potassium concentration might modify electrophysiological properties in the border zone (BZ) of ischemic myocardium. We evaluated the depolarization and repolarization characteristics across the ischemic-normal border under [K+] variation. 64-lead epicardial mapping was performed in 26 rats ([K+] 2.3-6.4 mM) in a model of acute ischemia/reperfusion. The animals with [K+]<4.7 mM (low-normal potassium) had an ischemic zone with ST-segment elevation and activation delay, a BZ with ST-segment elevation and no activ...
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Olesya Gennadievna Bernikova Aleksandra Durkina Mikhail Gonotkov Elena Minnebaeva Natalia Arteyeva Jan E Azarov Source Type: research

Azilsartan Prevents Muscle Loss and Fast to Slow-twitch Muscle Fibre Shift in Natural Ageing Sarcopenic Rats
In conclusion, the present findings showed that AZL could be an effective intervention in treating age-related muscle impairments.PMID:38118126 | DOI:10.1139/cjpp-2023-0265 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Priyanka Prajapati Anand Kumar Shubhada Mangulkar D R Chaple Shubhini A Saraf Sapana Kushwaha Source Type: research

Formation of a border ischemic zone depends on plasma potassium concentration
Can J Physiol Pharmacol. 2023 Dec 20. doi: 10.1139/cjpp-2023-0304. Online ahead of print.ABSTRACTExtracellular potassium concentration might modify electrophysiological properties in the border zone (BZ) of ischemic myocardium. We evaluated the depolarization and repolarization characteristics across the ischemic-normal border under [K+] variation. 64-lead epicardial mapping was performed in 26 rats ([K+] 2.3-6.4 mM) in a model of acute ischemia/reperfusion. The animals with [K+]<4.7 mM (low-normal potassium) had an ischemic zone with ST-segment elevation and activation delay, a BZ with ST-segment elevation and no activ...
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Olesya Gennadievna Bernikova Aleksandra Durkina Mikhail Gonotkov Elena Minnebaeva Natalia Arteyeva Jan E Azarov Source Type: research

Azilsartan Prevents Muscle Loss and Fast to Slow-twitch Muscle Fibre Shift in Natural Ageing Sarcopenic Rats
In conclusion, the present findings showed that AZL could be an effective intervention in treating age-related muscle impairments.PMID:38118126 | DOI:10.1139/cjpp-2023-0265 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Priyanka Prajapati Anand Kumar Shubhada Mangulkar D R Chaple Shubhini A Saraf Sapana Kushwaha Source Type: research

Formation of a border ischemic zone depends on plasma potassium concentration
Can J Physiol Pharmacol. 2023 Dec 20. doi: 10.1139/cjpp-2023-0304. Online ahead of print.ABSTRACTExtracellular potassium concentration might modify electrophysiological properties in the border zone (BZ) of ischemic myocardium. We evaluated the depolarization and repolarization characteristics across the ischemic-normal border under [K+] variation. 64-lead epicardial mapping was performed in 26 rats ([K+] 2.3-6.4 mM) in a model of acute ischemia/reperfusion. The animals with [K+]<4.7 mM (low-normal potassium) had an ischemic zone with ST-segment elevation and activation delay, a BZ with ST-segment elevation and no activ...
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Olesya Gennadievna Bernikova Aleksandra Durkina Mikhail Gonotkov Elena Minnebaeva Natalia Arteyeva Jan E Azarov Source Type: research

Azilsartan Prevents Muscle Loss and Fast to Slow-twitch Muscle Fibre Shift in Natural Ageing Sarcopenic Rats
In conclusion, the present findings showed that AZL could be an effective intervention in treating age-related muscle impairments.PMID:38118126 | DOI:10.1139/cjpp-2023-0265 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Priyanka Prajapati Anand Kumar Shubhada Mangulkar D R Chaple Shubhini A Saraf Sapana Kushwaha Source Type: research

Formation of a border ischemic zone depends on plasma potassium concentration
Can J Physiol Pharmacol. 2023 Dec 20. doi: 10.1139/cjpp-2023-0304. Online ahead of print.ABSTRACTExtracellular potassium concentration might modify electrophysiological properties in the border zone (BZ) of ischemic myocardium. We evaluated the depolarization and repolarization characteristics across the ischemic-normal border under [K+] variation. 64-lead epicardial mapping was performed in 26 rats ([K+] 2.3-6.4 mM) in a model of acute ischemia/reperfusion. The animals with [K+]<4.7 mM (low-normal potassium) had an ischemic zone with ST-segment elevation and activation delay, a BZ with ST-segment elevation and no activ...
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Olesya Gennadievna Bernikova Aleksandra Durkina Mikhail Gonotkov Elena Minnebaeva Natalia Arteyeva Jan E Azarov Source Type: research

Azilsartan Prevents Muscle Loss and Fast to Slow-twitch Muscle Fibre Shift in Natural Ageing Sarcopenic Rats
In conclusion, the present findings showed that AZL could be an effective intervention in treating age-related muscle impairments.PMID:38118126 | DOI:10.1139/cjpp-2023-0265 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Priyanka Prajapati Anand Kumar Shubhada Mangulkar D R Chaple Shubhini A Saraf Sapana Kushwaha Source Type: research

Formation of a border ischemic zone depends on plasma potassium concentration
Can J Physiol Pharmacol. 2023 Dec 20. doi: 10.1139/cjpp-2023-0304. Online ahead of print.ABSTRACTExtracellular potassium concentration might modify electrophysiological properties in the border zone (BZ) of ischemic myocardium. We evaluated the depolarization and repolarization characteristics across the ischemic-normal border under [K+] variation. 64-lead epicardial mapping was performed in 26 rats ([K+] 2.3-6.4 mM) in a model of acute ischemia/reperfusion. The animals with [K+]<4.7 mM (low-normal potassium) had an ischemic zone with ST-segment elevation and activation delay, a BZ with ST-segment elevation and no activ...
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Olesya Gennadievna Bernikova Aleksandra Durkina Mikhail Gonotkov Elena Minnebaeva Natalia Arteyeva Jan E Azarov Source Type: research

Azilsartan Prevents Muscle Loss and Fast to Slow-twitch Muscle Fibre Shift in Natural Ageing Sarcopenic Rats
In conclusion, the present findings showed that AZL could be an effective intervention in treating age-related muscle impairments.PMID:38118126 | DOI:10.1139/cjpp-2023-0265 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Priyanka Prajapati Anand Kumar Shubhada Mangulkar D R Chaple Shubhini A Saraf Sapana Kushwaha Source Type: research

Formation of a border ischemic zone depends on plasma potassium concentration
Can J Physiol Pharmacol. 2023 Dec 20. doi: 10.1139/cjpp-2023-0304. Online ahead of print.ABSTRACTExtracellular potassium concentration might modify electrophysiological properties in the border zone (BZ) of ischemic myocardium. We evaluated the depolarization and repolarization characteristics across the ischemic-normal border under [K+] variation. 64-lead epicardial mapping was performed in 26 rats ([K+] 2.3-6.4 mM) in a model of acute ischemia/reperfusion. The animals with [K+]<4.7 mM (low-normal potassium) had an ischemic zone with ST-segment elevation and activation delay, a BZ with ST-segment elevation and no activ...
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Olesya Gennadievna Bernikova Aleksandra Durkina Mikhail Gonotkov Elena Minnebaeva Natalia Arteyeva Jan E Azarov Source Type: research

Azilsartan Prevents Muscle Loss and Fast to Slow-twitch Muscle Fibre Shift in Natural Ageing Sarcopenic Rats
In conclusion, the present findings showed that AZL could be an effective intervention in treating age-related muscle impairments.PMID:38118126 | DOI:10.1139/cjpp-2023-0265 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Priyanka Prajapati Anand Kumar Shubhada Mangulkar D R Chaple Shubhini A Saraf Sapana Kushwaha Source Type: research

Formation of a border ischemic zone depends on plasma potassium concentration
Can J Physiol Pharmacol. 2023 Dec 20. doi: 10.1139/cjpp-2023-0304. Online ahead of print.ABSTRACTExtracellular potassium concentration might modify electrophysiological properties in the border zone (BZ) of ischemic myocardium. We evaluated the depolarization and repolarization characteristics across the ischemic-normal border under [K+] variation. 64-lead epicardial mapping was performed in 26 rats ([K+] 2.3-6.4 mM) in a model of acute ischemia/reperfusion. The animals with [K+]<4.7 mM (low-normal potassium) had an ischemic zone with ST-segment elevation and activation delay, a BZ with ST-segment elevation and no activ...
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Olesya Gennadievna Bernikova Aleksandra Durkina Mikhail Gonotkov Elena Minnebaeva Natalia Arteyeva Jan E Azarov Source Type: research

Azilsartan Prevents Muscle Loss and Fast to Slow-twitch Muscle Fibre Shift in Natural Ageing Sarcopenic Rats
In conclusion, the present findings showed that AZL could be an effective intervention in treating age-related muscle impairments.PMID:38118126 | DOI:10.1139/cjpp-2023-0265 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Priyanka Prajapati Anand Kumar Shubhada Mangulkar D R Chaple Shubhini A Saraf Sapana Kushwaha Source Type: research

Formation of a border ischemic zone depends on plasma potassium concentration
Can J Physiol Pharmacol. 2023 Dec 20. doi: 10.1139/cjpp-2023-0304. Online ahead of print.ABSTRACTExtracellular potassium concentration might modify electrophysiological properties in the border zone (BZ) of ischemic myocardium. We evaluated the depolarization and repolarization characteristics across the ischemic-normal border under [K+] variation. 64-lead epicardial mapping was performed in 26 rats ([K+] 2.3-6.4 mM) in a model of acute ischemia/reperfusion. The animals with [K+]<4.7 mM (low-normal potassium) had an ischemic zone with ST-segment elevation and activation delay, a BZ with ST-segment elevation and no activ...
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Olesya Gennadievna Bernikova Aleksandra Durkina Mikhail Gonotkov Elena Minnebaeva Natalia Arteyeva Jan E Azarov Source Type: research