Canadian Journal of Physiology and Pharmacology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Diabetic Complications
Can J Physiol Pharmacol. 2023 Sep 25. doi: 10.1139/cjpp-2023-0223. Online ahead of print.ABSTRACTCardiovascular (CVD) complications have remained a major cause of death among patients with diabetes. Hence the need for effective therapeutics against diabetes-induced CVD complications. Since its discovery, proprotein convertase subtilisin/kexin type 9 (PCSK9) has been reported to be involved in the pathology of various cardiovascular diseases, with studies showing a positive association between plasma levels of PCSK9, hyperglycemia, and dyslipidemia. PCSK9 regulates lipid homeostasis by interacting with low-density lipoprote...
Source: Canadian Journal of Physiology and Pharmacology - September 25, 2023 Category: Drugs & Pharmacology Authors: Omonzejie E Imaralu Chandrakala Aluganti Narasimhulu Pawan K Singal Dinender Kumar Singla Source Type: research
Tumour adaptation to immune factors: old and new ideas for cancer immunotherapy
Can J Physiol Pharmacol. 2023 Sep 20. doi: 10.1139/cjpp-2023-0083. Online ahead of print.ABSTRACTThe tumour is fully functional in the zone of action of immune mediators. Moreover, the tumour needs immune system mediators to survive. "Adaptation" refers to a tumour's ability to withstand the effect of harmful elements. This gives birth to a new form of antitumour therapy: blocking tumour adaptability pathways. In this review, we will look at (i) tumour adaptation mechanisms as a result of pro-tumour immunoediting, (ii) how understanding tumour-adaptive mechanisms has led to ideas for developing cancer immunotherapies, and ...
Source: Canadian Journal of Physiology and Pharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: I Yu Malyshev O P Budanova L V Kuznetsova Source Type: research
Tumour adaptation to immune factors: old and new ideas for cancer immunotherapy
Can J Physiol Pharmacol. 2023 Sep 20. doi: 10.1139/cjpp-2023-0083. Online ahead of print.ABSTRACTThe tumour is fully functional in the zone of action of immune mediators. Moreover, the tumour needs immune system mediators to survive. "Adaptation" refers to a tumour's ability to withstand the effect of harmful elements. This gives birth to a new form of antitumour therapy: blocking tumour adaptability pathways. In this review, we will look at (i) tumour adaptation mechanisms as a result of pro-tumour immunoediting, (ii) how understanding tumour-adaptive mechanisms has led to ideas for developing cancer immunotherapies, and ...
Source: Canadian Journal of Physiology and Pharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: I Yu Malyshev O P Budanova L V Kuznetsova Source Type: research
Tumour adaptation to immune factors: old and new ideas for cancer immunotherapy
Can J Physiol Pharmacol. 2023 Sep 20. doi: 10.1139/cjpp-2023-0083. Online ahead of print.ABSTRACTThe tumour is fully functional in the zone of action of immune mediators. Moreover, the tumour needs immune system mediators to survive. "Adaptation" refers to a tumour's ability to withstand the effect of harmful elements. This gives birth to a new form of antitumour therapy: blocking tumour adaptability pathways. In this review, we will look at (i) tumour adaptation mechanisms as a result of pro-tumour immunoediting, (ii) how understanding tumour-adaptive mechanisms has led to ideas for developing cancer immunotherapies, and ...
Source: Canadian Journal of Physiology and Pharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: I Yu Malyshev O P Budanova L V Kuznetsova Source Type: research
Tumour adaptation to immune factors: old and new ideas for cancer immunotherapy
Can J Physiol Pharmacol. 2023 Sep 20. doi: 10.1139/cjpp-2023-0083. Online ahead of print.ABSTRACTThe tumour is fully functional in the zone of action of immune mediators. Moreover, the tumour needs immune system mediators to survive. "Adaptation" refers to a tumour's ability to withstand the effect of harmful elements. This gives birth to a new form of antitumour therapy: blocking tumour adaptability pathways. In this review, we will look at (i) tumour adaptation mechanisms as a result of pro-tumour immunoediting, (ii) how understanding tumour-adaptive mechanisms has led to ideas for developing cancer immunotherapies, and ...
Source: Canadian Journal of Physiology and Pharmacology - September 20, 2023 Category: Drugs & Pharmacology Authors: I Yu Malyshev O P Budanova L V Kuznetsova Source Type: research
Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor- κB and platelet aggregation in type 2 diabetic patients
In conclusion, restoring normal levels of vitamin D is an important determinant to maintain normal platelet function and reduce inflammation. Nevertheless, further long-term studies are still needed.PMID:37721213 | DOI:10.1139/cjpp-2022-0359 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - September 18, 2023 Category: Drugs & Pharmacology Authors: Esraa Habiba Samia Ali Yehia Ghanem Ola Sharaki Wafaa Hewedy Source Type: research
Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor- κB and platelet aggregation in type 2 diabetic patients
In conclusion, restoring normal levels of vitamin D is an important determinant to maintain normal platelet function and reduce inflammation. Nevertheless, further long-term studies are still needed.PMID:37721213 | DOI:10.1139/cjpp-2022-0359 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - September 18, 2023 Category: Drugs & Pharmacology Authors: Esraa Habiba Samia Ali Yehia Ghanem Ola Sharaki Wafaa Hewedy Source Type: research
Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor- κB and platelet aggregation in type 2 diabetic patients
In conclusion, restoring normal levels of vitamin D is an important determinant to maintain normal platelet function and reduce inflammation. Nevertheless, further long-term studies are still needed.PMID:37721213 | DOI:10.1139/cjpp-2022-0359 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - September 18, 2023 Category: Drugs & Pharmacology Authors: Esraa Habiba Samia Ali Yehia Ghanem Ola Sharaki Wafaa Hewedy Source Type: research
Potential Benefits of Therapeutic Drug Monitoring for Beta-lactam Antibiotics in Augmented Renal Clearance Patients: A Case Report
CONCLUSION: Suboptimal administration could not only lead to treatment failure, but to the selection and growth of resistant pathogens. Implementing TDM would offer the possibility to adjust drug regimens in real time and prevent situations like these to happen.PMID:37713726 | DOI:10.1139/cjpp-2023-0109 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - September 15, 2023 Category: Drugs & Pharmacology Authors: Ibrahim El-Haffaf Jean Laverdi ère Martin Albert Am élie Marsot David Williamson Source Type: research
Potential Benefits of Therapeutic Drug Monitoring for Beta-lactam Antibiotics in Augmented Renal Clearance Patients: A Case Report
CONCLUSION: Suboptimal administration could not only lead to treatment failure, but to the selection and growth of resistant pathogens. Implementing TDM would offer the possibility to adjust drug regimens in real time and prevent situations like these to happen.PMID:37713726 | DOI:10.1139/cjpp-2023-0109 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - September 15, 2023 Category: Drugs & Pharmacology Authors: Ibrahim El-Haffaf Jean Laverdi ère Martin Albert Am élie Marsot David Williamson Source Type: research
Potential Benefits of Therapeutic Drug Monitoring for Beta-lactam Antibiotics in Augmented Renal Clearance Patients: A Case Report
CONCLUSION: Suboptimal administration could not only lead to treatment failure, but to the selection and growth of resistant pathogens. Implementing TDM would offer the possibility to adjust drug regimens in real time and prevent situations like these to happen.PMID:37713726 | DOI:10.1139/cjpp-2023-0109 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - September 15, 2023 Category: Drugs & Pharmacology Authors: Ibrahim El-Haffaf Jean Laverdi ère Martin Albert Am élie Marsot David Williamson Source Type: research
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma
This study plans to establish a survival prognosis model for colon adenocarcinoma (COAD) patients based on cuproptosis-related genes (CRGs). We investigated the genetic alterations of CRGs in COAD based on The Cancer Genome Atlas database and validated in the GSE41328 dataset. Our results showed that LIPT1, PDHA1, GLS, and CDKN2A had significantly higher expression in COAD tissues than in normal tissues, while FDX1, DLD, and MTF1 had significantly lower expression in COAD tissues than in normal tissues (|(log2(fold change))| > 2, p < 0.05). DLD (hazard ratio (HR): 0.658; 95% confidence interval (CI): 0.445, 0.974; p ...
Source: Canadian Journal of Physiology and Pharmacology - September 12, 2023 Category: Drugs & Pharmacology Authors: Yongqin Su Kun Zhang Source Type: research
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma
This study plans to establish a survival prognosis model for colon adenocarcinoma (COAD) patients based on cuproptosis-related genes (CRGs). We investigated the genetic alterations of CRGs in COAD based on The Cancer Genome Atlas database and validated in the GSE41328 dataset. Our results showed that LIPT1, PDHA1, GLS, and CDKN2A had significantly higher expression in COAD tissues than in normal tissues, while FDX1, DLD, and MTF1 had significantly lower expression in COAD tissues than in normal tissues (|(log2(fold change))| > 2, p < 0.05). DLD (hazard ratio (HR): 0.658; 95% confidence interval (CI): 0.445, 0.974; p ...
Source: Canadian Journal of Physiology and Pharmacology - September 12, 2023 Category: Drugs & Pharmacology Authors: Yongqin Su Kun Zhang Source Type: research
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma
This study plans to establish a survival prognosis model for colon adenocarcinoma (COAD) patients based on cuproptosis-related genes (CRGs). We investigated the genetic alterations of CRGs in COAD based on The Cancer Genome Atlas database and validated in the GSE41328 dataset. Our results showed that LIPT1, PDHA1, GLS, and CDKN2A had significantly higher expression in COAD tissues than in normal tissues, while FDX1, DLD, and MTF1 had significantly lower expression in COAD tissues than in normal tissues (|(log2(fold change))| > 2, p < 0.05). DLD (hazard ratio (HR): 0.658; 95% confidence interval (CI): 0.445, 0.974; p ...
Source: Canadian Journal of Physiology and Pharmacology - September 12, 2023 Category: Drugs & Pharmacology Authors: Yongqin Su Kun Zhang Source Type: research
Astaxanthin prevent nephrotoxicity through Nrf2/HO-1 pathway
Can J Physiol Pharmacol. 2023 Sep 8. doi: 10.1139/cjpp-2023-0015. Online ahead of print.ABSTRACTRenal toxicity is one of the side effects of methotrexate (MTX). Therefore, this study explored the use of Astaxanthin, as a natural carotenoid, against MTX-induced nephrotoxicity emphasizing the changes in oxidative stress and the expression of nuclear factor (erythroid-derived 2)-like 2/heme oxygenase 1 (Nrf2/HO-1). During the ten days of the experiment, male Wistar rats in different groups received methotrexate (10 mg/kg) on days 6, 8, and 10 and three doses of astaxanthin (25, 50, and 75 mg/kg) on the entire course. Renal fa...
Source: Canadian Journal of Physiology and Pharmacology - September 8, 2023 Category: Drugs & Pharmacology Authors: Faezeh Lorestani Ahmad Movahedian Adel Mohammadalipour Mohammad Hashemnia Mohammad Hossein Aarabi Source Type: research
