Canadian Journal of Physiology and Pharmacology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Alleviation of adipose-hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF- κB/NLRP3 repression
This study hypothesized that acetate breaks the vicious cycle driving adipose-hepatic metabolic dysregulation in a rat model of PCOS, possibly by suppression of NF-κB/NLRP3 inflammasome. Female Wistar rats (eight-week-old) were randomly allocated into 4 groups of n=six/group, which received vehicle, sodium acetate (200 mg), letrozole (1 mg/kg) and letrozole plus sodium acetate respectively. The animals were treated by oral gavage, once daily for a period of 21 days. The PCOS animals were insulin resistant, hyperandrogenic and hypoestrogenic with decreased sex hormone binding globulin. In addition, the hepatic tissue had i...
Source: Canadian Journal of Physiology and Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Authors: Kehinde S Olaniyi Stephanie E Areloegbe Source Type: research
Alleviation of adipose-hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF- κB/NLRP3 repression
This study hypothesized that acetate breaks the vicious cycle driving adipose-hepatic metabolic dysregulation in a rat model of PCOS, possibly by suppression of NF-κB/NLRP3 inflammasome. Female Wistar rats (eight-week-old) were randomly allocated into 4 groups of n=six/group, which received vehicle, sodium acetate (200 mg), letrozole (1 mg/kg) and letrozole plus sodium acetate respectively. The animals were treated by oral gavage, once daily for a period of 21 days. The PCOS animals were insulin resistant, hyperandrogenic and hypoestrogenic with decreased sex hormone binding globulin. In addition, the hepatic tissue had i...
Source: Canadian Journal of Physiology and Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Authors: Kehinde S Olaniyi Stephanie E Areloegbe Source Type: research
Alleviation of adipose-hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF- κB/NLRP3 repression
This study hypothesized that acetate breaks the vicious cycle driving adipose-hepatic metabolic dysregulation in a rat model of PCOS, possibly by suppression of NF-κB/NLRP3 inflammasome. Female Wistar rats (eight-week-old) were randomly allocated into 4 groups of n=six/group, which received vehicle, sodium acetate (200 mg), letrozole (1 mg/kg) and letrozole plus sodium acetate respectively. The animals were treated by oral gavage, once daily for a period of 21 days. The PCOS animals were insulin resistant, hyperandrogenic and hypoestrogenic with decreased sex hormone binding globulin. In addition, the hepatic tissue had i...
Source: Canadian Journal of Physiology and Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Authors: Kehinde S Olaniyi Stephanie E Areloegbe Source Type: research
Alleviation of adipose-hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF- κB/NLRP3 repression
This study hypothesized that acetate breaks the vicious cycle driving adipose-hepatic metabolic dysregulation in a rat model of PCOS, possibly by suppression of NF-κB/NLRP3 inflammasome. Female Wistar rats (eight-week-old) were randomly allocated into 4 groups of n=six/group, which received vehicle, sodium acetate (200 mg), letrozole (1 mg/kg) and letrozole plus sodium acetate respectively. The animals were treated by oral gavage, once daily for a period of 21 days. The PCOS animals were insulin resistant, hyperandrogenic and hypoestrogenic with decreased sex hormone binding globulin. In addition, the hepatic tissue had i...
Source: Canadian Journal of Physiology and Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Authors: Kehinde S Olaniyi Stephanie E Areloegbe Source Type: research
Alleviation of adipose-hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF- κB/NLRP3 repression
This study hypothesized that acetate breaks the vicious cycle driving adipose-hepatic metabolic dysregulation in a rat model of PCOS, possibly by suppression of NF-κB/NLRP3 inflammasome. Female Wistar rats (eight-week-old) were randomly allocated into 4 groups of n=six/group, which received vehicle, sodium acetate (200 mg), letrozole (1 mg/kg) and letrozole plus sodium acetate respectively. The animals were treated by oral gavage, once daily for a period of 21 days. The PCOS animals were insulin resistant, hyperandrogenic and hypoestrogenic with decreased sex hormone binding globulin. In addition, the hepatic tissue had i...
Source: Canadian Journal of Physiology and Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Authors: Kehinde S Olaniyi Stephanie E Areloegbe Source Type: research
Alleviation of adipose-hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF- κB/NLRP3 repression
This study hypothesized that acetate breaks the vicious cycle driving adipose-hepatic metabolic dysregulation in a rat model of PCOS, possibly by suppression of NF-κB/NLRP3 inflammasome. Female Wistar rats (eight-week-old) were randomly allocated into 4 groups of n=six/group, which received vehicle, sodium acetate (200 mg), letrozole (1 mg/kg) and letrozole plus sodium acetate respectively. The animals were treated by oral gavage, once daily for a period of 21 days. The PCOS animals were insulin resistant, hyperandrogenic and hypoestrogenic with decreased sex hormone binding globulin. In addition, the hepatic tissue had i...
Source: Canadian Journal of Physiology and Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Authors: Kehinde S Olaniyi Stephanie E Areloegbe Source Type: research
Alleviation of adipose-hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF- κB/NLRP3 repression
This study hypothesized that acetate breaks the vicious cycle driving adipose-hepatic metabolic dysregulation in a rat model of PCOS, possibly by suppression of NF-κB/NLRP3 inflammasome. Female Wistar rats (eight-week-old) were randomly allocated into 4 groups of n=six/group, which received vehicle, sodium acetate (200 mg), letrozole (1 mg/kg) and letrozole plus sodium acetate respectively. The animals were treated by oral gavage, once daily for a period of 21 days. The PCOS animals were insulin resistant, hyperandrogenic and hypoestrogenic with decreased sex hormone binding globulin. In addition, the hepatic tissue had i...
Source: Canadian Journal of Physiology and Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Authors: Kehinde S Olaniyi Stephanie E Areloegbe Source Type: research
Alleviation of adipose-hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF- κB/NLRP3 repression
This study hypothesized that acetate breaks the vicious cycle driving adipose-hepatic metabolic dysregulation in a rat model of PCOS, possibly by suppression of NF-κB/NLRP3 inflammasome. Female Wistar rats (eight-week-old) were randomly allocated into 4 groups of n=six/group, which received vehicle, sodium acetate (200 mg), letrozole (1 mg/kg) and letrozole plus sodium acetate respectively. The animals were treated by oral gavage, once daily for a period of 21 days. The PCOS animals were insulin resistant, hyperandrogenic and hypoestrogenic with decreased sex hormone binding globulin. In addition, the hepatic tissue had i...
Source: Canadian Journal of Physiology and Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Authors: Kehinde S Olaniyi Stephanie E Areloegbe Source Type: research
Alleviation of adipose-hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF- κB/NLRP3 repression
This study hypothesized that acetate breaks the vicious cycle driving adipose-hepatic metabolic dysregulation in a rat model of PCOS, possibly by suppression of NF-κB/NLRP3 inflammasome. Female Wistar rats (eight-week-old) were randomly allocated into 4 groups of n=six/group, which received vehicle, sodium acetate (200 mg), letrozole (1 mg/kg) and letrozole plus sodium acetate respectively. The animals were treated by oral gavage, once daily for a period of 21 days. The PCOS animals were insulin resistant, hyperandrogenic and hypoestrogenic with decreased sex hormone binding globulin. In addition, the hepatic tissue had i...
Source: Canadian Journal of Physiology and Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Authors: Kehinde S Olaniyi Stephanie E Areloegbe Source Type: research
Copaiba oil improves pulmonary nitric oxide bioavailability in monocrotaline-treated rats
In conclusion, copaiba oil was able to improve the balance between nitric oxide and reactive oxygen species in lungs and the pulmonary artery and to reduce PVR, which could explain a decrease in RV hypertrophy in this PAH model.PMID:37581356 | DOI:10.1139/cjpp-2023-0028 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - August 15, 2023 Category: Drugs & Pharmacology Authors: Cristina Campos-Carraro Patrick Turck Bruna Gazzi de Lima-Seolin Rayane Brinck Teixeira Alexsandra Zimmer Alex Sander da Rosa Araujo Adriane Bell ó-Klein Source Type: research
Copaiba oil improves pulmonary nitric oxide bioavailability in monocrotaline-treated rats
In conclusion, copaiba oil was able to improve the balance between nitric oxide and reactive oxygen species in lungs and the pulmonary artery and to reduce PVR, which could explain a decrease in RV hypertrophy in this PAH model.PMID:37581356 | DOI:10.1139/cjpp-2023-0028 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - August 15, 2023 Category: Drugs & Pharmacology Authors: Cristina Campos-Carraro Patrick Turck Bruna Gazzi de Lima-Seolin Rayane Brinck Teixeira Alexsandra Zimmer Alex Sander da Rosa Araujo Adriane Bell ó-Klein Source Type: research
Copaiba oil improves pulmonary nitric oxide bioavailability in monocrotaline-treated rats
In conclusion, copaiba oil was able to improve the balance between nitric oxide and reactive oxygen species in lungs and the pulmonary artery and to reduce PVR, which could explain a decrease in RV hypertrophy in this PAH model.PMID:37581356 | DOI:10.1139/cjpp-2023-0028 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - August 15, 2023 Category: Drugs & Pharmacology Authors: Cristina Campos-Carraro Patrick Turck Bruna Gazzi de Lima-Seolin Rayane Brinck Teixeira Alexsandra Zimmer Alex Sander da Rosa Araujo Adriane Bell ó-Klein Source Type: research
Effects of a high-fat low-carbohydrate diet under different energy conditions on glucose homeostasis and fatty liver development in rats and on gluconeogenesis in the isolated perfused liver
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0071. Online ahead of print.ABSTRACTThe beneficial effects of high-fat, low-carbohydrate diets (HFLC) on glucose metabolism have been questioned and its effects on liver metabolism are not totally clear. The aim of this work was to investigate the effects of a HFLC diet under different energy conditions on glucose homeostasis, fatty liver development and hepatic gluconeogenesis using the isolated perfused rat liver. HFLC diet (79% fat, 19% protein, and 2% carbohydrates in Kcal%) was administered to rats for four weeks under three conditions: ad libitum (hypercalo...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Mateus Jos é de Oliveira Evelyn Silva Moreira Naiara Cristina Lucredi Carla Indianara Bonetti Anacharis Babeto de S á-Nakanishi Jurandir Fernando Comar Adelar Bracht L ívia Bracht Source Type: research
Alpha-Lipoic Acid Enhances Ischemic Postconditioning-Mediated Improvement of Myocardial Infarction and Apoptosis in Diabetic Rats with Ischemia/Reperfusion Injury
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0044. Online ahead of print.ABSTRACTThis work evaluated the combined effects of alpha-lipoic acid (ALA) and ischemic-postconditioning (Post) on myocardial infarction and cell death in rats with chronic type-2 diabetes following ischemia/reperfusion injury. The rats received a high-fat diet and were given one intraperitoneal injection of 35 mg/kg streptozotocin to induce chronic diabetes. They were then pretreated with ALA (100 mg/kg/day, orally) for five weeks before undergoing I/R insult. The hearts experienced 35-minute regional ischemia through ligating the le...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Sanaz Gholami Reza Badalzadeh Alireza AliHemmati Source Type: research
Effects of a high-fat low-carbohydrate diet under different energy conditions on glucose homeostasis and fatty liver development in rats and on gluconeogenesis in the isolated perfused liver
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0071. Online ahead of print.ABSTRACTThe beneficial effects of high-fat, low-carbohydrate diets (HFLC) on glucose metabolism have been questioned and its effects on liver metabolism are not totally clear. The aim of this work was to investigate the effects of a HFLC diet under different energy conditions on glucose homeostasis, fatty liver development and hepatic gluconeogenesis using the isolated perfused rat liver. HFLC diet (79% fat, 19% protein, and 2% carbohydrates in Kcal%) was administered to rats for four weeks under three conditions: ad libitum (hypercalo...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Mateus Jos é de Oliveira Evelyn Silva Moreira Naiara Cristina Lucredi Carla Indianara Bonetti Anacharis Babeto de S á-Nakanishi Jurandir Fernando Comar Adelar Bracht L ívia Bracht Source Type: research
