Canadian Journal of Physiology and Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Formation of a border ischemic zone depends on plasma potassium concentration
Can J Physiol Pharmacol. 2023 Dec 20. doi: 10.1139/cjpp-2023-0304. Online ahead of print.ABSTRACTExtracellular potassium concentration might modify electrophysiological properties in the border zone (BZ) of ischemic myocardium. We evaluated the depolarization and repolarization characteristics across the ischemic-normal border under [K+] variation. 64-lead epicardial mapping was performed in 26 rats ([K+] 2.3-6.4 mM) in a model of acute ischemia/reperfusion. The animals with [K+]<4.7 mM (low-normal potassium) had an ischemic zone with ST-segment elevation and activation delay, a BZ with ST-segment elevation and no activ...
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Olesya Gennadievna Bernikova Aleksandra Durkina Mikhail Gonotkov Elena Minnebaeva Natalia Arteyeva Jan E Azarov Source Type: research

Azilsartan Prevents Muscle Loss and Fast to Slow-twitch Muscle Fibre Shift in Natural Ageing Sarcopenic Rats
In conclusion, the present findings showed that AZL could be an effective intervention in treating age-related muscle impairments.PMID:38118126 | DOI:10.1139/cjpp-2023-0265 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Priyanka Prajapati Anand Kumar Shubhada Mangulkar D R Chaple Shubhini A Saraf Sapana Kushwaha Source Type: research

The role of melatonin in preventing amiodarone induced rat liver damage
In conclusion the application of melatonin together with amiodarone prevented an increase in tissue oxidative damage parameters and moderately prevented liver cell apoptosis, indicating that the damage of hepatocytes provoked by amiodarone supersedes the protective properties of melatonin in a given dose.PMID:38079620 | DOI:10.1139/cjpp-2023-0253 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Dejan Petrovi ć Marina Deljanin Ili ć Dejan Simonovi ć Milovan Stojanovi ć Milica Stankovi ć Slavi ša Stanišić Sanja Stojanovi ć Neboj ša Arsić Dusan Sokolovic Source Type: research

Salvianolic acid B attenuates diabetic nephropathy through alleviating ADORA2B, NALP3 inflammasome, and NF κB activity
This study is aimed at investigating the role and mechanisms of Salvianolic acid B (Sal B) in diabetic nephropathy. High glucose (HG)-induced human renal tubular epithelial HK-2 cells were treated with Sal B, BAY-60-6583(agonist of Adenosine 2B receptor) or PSB-603(antagonist of Adenosine 2B receptor) for 24 hours. Adenosine A2b-receptor (ADORA2B), NACHT, leucine-rich repeat (LRR) and pyrin (PYD) domains-containing protein 3 (NALP3), and nuclear factor Kappa B (NFκB) expressions, mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) levels were examined. Following 6-week of Sal B treatment, db/db mice b...
Source: Canadian Journal of Physiology and Pharmacology - December 9, 2023 Category: Drugs & Pharmacology Authors: Ying Wang Jiang Chang Shubin Qiao Ying Yang Chuan Yun Yongyan Li Fa Wang Source Type: research

Time to treat the climate and nature crisis as one indivisible global health emergency
Can J Physiol Pharmacol. 2023 Dec 1;101(12):i-iii. doi: 10.1139/cjpp-2023-0431.NO ABSTRACTPMID:38038226 | DOI:10.1139/cjpp-2023-0431 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 1, 2023 Category: Drugs & Pharmacology Source Type: research