Canadian Journal of Physiology and Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The role of the circadian clock system in mitochondrial trans-sulfuration pathway and tissue remodeling
Can J Physiol Pharmacol. 2023 Nov 18. doi: 10.1139/cjpp-2023-0186. Online ahead of print.ABSTRACTHydrogen sulfide (H2S) is a product of epigenetics that involves trans-sulfuration pathway for clearance of homocysteine (Hcy), thereby mitigating skeletal muscle's pathological remodeling. Although master circadian clock regulator that is known as brain and muscle aryl hydrocarbon receptor nuclear translocator like protein 1 (i.e., BMAL1) is associated with S-adenosylhomocysteine hydrolase and Hcy metabolism but how trans-sulfuration is influenced by circadian clock remains unexplored. We hypothesize that alterations in functi...
Source: Canadian Journal of Physiology and Pharmacology - November 18, 2023 Category: Drugs & Pharmacology Authors: Suresh C Tyagi Sathnur Pushpakumar Utpal Sen Oluwaseun E Akinterinwa Yuting Zheng Sri Prakash L Mokshagundam Dinesh K Kalra Mahavir Singh Source Type: research

Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission
This study aimed to investigate PⅡ in the modulation of spinal synaptic transmission mechanisms on pain hypersensitivity in neuropathic rats. We investigated the analgesia of PⅡ in mechanical and thermal hyperalgesia using the spinal nerve ligation (SNL)-induced neuropathic pain model and formalin-induced tonic pain model, respectively. RNA sequencing and network pharmacology were employed to screen core targets and signaling pathways. Immunofluorescence staining and qPCR were performed to explore the expression level of microglia and inflammatory mediator mRNA. The whole-cell patch‑clamp recordings were utilized to ...
Source: Canadian Journal of Physiology and Pharmacology - November 17, 2023 Category: Drugs & Pharmacology Authors: Dongxia Duan Lian Wang Yueyang Feng Daiyu Hu Donghong Cui Source Type: research

Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice
Can J Physiol Pharmacol. 2023 Nov 17. doi: 10.1139/cjpp-2023-0268. Online ahead of print.ABSTRACTSclerostin, a potent inhibitor of the Wnt signaling pathway, plays a critical role in bone homeostasis. Evidence suggests that sclerostin may also be involved in crosstalk between other tissues, including muscle. This pilot study attempted to examine the effects of sclerostin on soleus and extensor digitorum longus (EDL) muscle tissue from male mice that were given continuous recombinant sclerostin injections for four weeks. A total of 48 10-week-old male C57BL/6J mice were assigned to be sedentary or perform 1-hour treadmill r...
Source: Canadian Journal of Physiology and Pharmacology - November 17, 2023 Category: Drugs & Pharmacology Authors: Joshua Stoikos Nigel Kurgan Steven Kottaras Val A Fajardo William Gittings Panagiota Klentrou Source Type: research

Nitric oxide and potassium channels but not opioid and cannabinoid receptors mediate tramadol-induced peripheral antinociception in rat model of paw pressure withdrawal
This study aimed to explore these mechanisms, specifically the opioid-, cannabinoid-, nitric oxide-, and potassium channel-based mechanisms, which contributes to the peripheral antinociception effect of tramadol, in an experimental rat model. The nociceptive threshold was determined using paw pressure withdrawal. To examine the mechanisms of action, several substances were administered intraplantarly: naloxone, a non-selective opioid antagonist (50 μg/paw); AM251 (80 μg/paw) and AM630 (100 μg/paw) as the selective antagonists for type 1 and type 2 cannabinoid receptors, respectively; nitric oxide synthase inhibitors L-N...
Source: Canadian Journal of Physiology and Pharmacology - November 17, 2023 Category: Drugs & Pharmacology Authors: Raquel R Soares-Santos Daniel P Machado Thiago Lima Romero Igor Duarte Source Type: research

TLR/mTOR inflammatory signaling pathway: novel insight for the treatment of schizophrenia
The objective of the present work was to find a novel anti-inflammatory agent that may block the mTOR/TLR inflammatory signaling pathways and might pave the way for the treatment of neuroinflammatory SCZ. Data were collected from experimental and clinical studies published in English between 1998 and October 2022 from Google Scholar, PubMed, Scopus, and the Cochrane library.PMID:37955633 | DOI:10.1139/cjpp-2023-0107 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - November 13, 2023 Category: Drugs & Pharmacology Authors: Naser-Aldin Lashgari Nazanin Momeni Roudsari Hedieh Sadat Shamsnia Maryam Shayan Saeideh Momtaz Amir Hossein Abdolghaffari Source Type: research

SCH772984 ameliorates lipopolysaccharide induced hypoglycemia in mice through reversing MEK/ERK/Foxo1 mediated gluconeogenesis suppression
This study intends to investigate the signaling pathways involved in LPS-induced hypoglycemia and potential efficacy of ERK inhibitor SCH772984. The effects of LPS and SCH772984 on gluconeogenesis, glucose absorption and glycogenolysis were evaluated by pyruvate tolerance test (PTT), oral glucose tolerance test (OGTT) and glucagon test, respectively. After a single intraperitoneal injection of 0.5 mg/kg LPS, the mice's blood glucose levels and gluconeogenesis ability were significantly lower than that of control group. Besides, mRNA and protein expression of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykin...
Source: Canadian Journal of Physiology and Pharmacology - November 9, 2023 Category: Drugs & Pharmacology Authors: Yirong Wang Shuyun Qing Jing Yang Dehui Qian Source Type: research

Vascular effects of midazolam, flumazenil, and a novel imidazobenzodiazepine MP-III-058 on isolated rat aorta
Can J Physiol Pharmacol. 2023 Nov 1. doi: 10.1139/cjpp-2023-0285. Online ahead of print.ABSTRACTHypotensive influences of benzodiazepines and other GABAA receptor ligands, recognized in clinical practice, seem to stem from the existence of "vascular" GABAA receptors in peripheral blood vessels, besides any mechanisms in the central and peripheral nervous systems. We aimed to further elucidate the vasodilatatory effects of ligands acting through GABAA receptors. Using immunohistochemistry, the rat aortic smooth muscle layer was found to express GABAA γ2 and α1-5 subunit proteins. To confirm the role of "vascular" GABAA re...
Source: Canadian Journal of Physiology and Pharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Milica Gaji ć Bojić Marco Treven Kamal P Pandey V V N Phani Babu Tiruveedhula Anja Santra č Đorđe Đukanović Nata ša Vojinović Ljiljana Amid žić Ranko Škrbić Petra Scholze Margot Ernst James M Cook Miroslav M Savi ć Source Type: research