Canadian Journal of Physiology and Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Fishing antioxidant 4-hydroxycoumarin derivatives: synthesis, characterization, and in vitro assessments
Can J Physiol Pharmacol. 2024 Mar 6. doi: 10.1139/cjpp-2023-0455. Online ahead of print.ABSTRACTIn this work the antioxidant activity of eighteen 4-hydroxycoumarin coumarin derivatives was assessed, six of which are commercially available and the other twelve were synthesized and chemically characterized. The 4-hydroxycoumarins were prepared by a two steps synthetic strategy with satisfactory yields. Their antioxidant potential was evaluated through three in vitro methods, two free radical-scavenging assays (DPPH• and ABTS•+) and a metal chelating activity assay. Six synthetic coumarins (4a, 4g, 4h, 4i, 4k, 4l) had a s...
Source: Canadian Journal of Physiology and Pharmacology - March 6, 2024 Category: Drugs & Pharmacology Authors: Batoul Rostom Elizabeth Goya-Jorge Liliana Vicet Muro Imrane Boubrik Sarah Wiorek Racha Karaky Issam Kassab Mar ía Elisa Jorge Rodríguez Mait é Sylla-Iyarreta Veitía Source Type: research

"HFpEF and Sex: Understanding the Role of Sex Differences"
Can J Physiol Pharmacol. 2024 Mar 6. doi: 10.1139/cjpp-2023-0403. Online ahead of print.ABSTRACTHeart failure is a complex clinical syndrome with many etiological factors and complex pathophysiology affecting millions worldwide. Males and females can have distinct clinical presentation and prognosis, and there is emerging understanding of the factors that highlight the similarities and differences to synthesize and present available data for sex-specific differences in HFpEF. While the majority of data demonstrates more similarities than differences between females and males in terms of heart failure, there are key differe...
Source: Canadian Journal of Physiology and Pharmacology - March 6, 2024 Category: Drugs & Pharmacology Authors: Yuliia Smereka Justin A Ezekowitz Source Type: research

Epigenetic Regulation of Sex Dimorphism in Cardiovascular Health
Can J Physiol Pharmacol. 2024 Mar 1. doi: 10.1139/cjpp-2023-0406. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality, affecting people of all races, ages, and sexs. Substantial sex dimorphism exists in the prevalence, manifestation, and outcomes of cardiovascular diseases (CVD). Understanding the role of sex hormones as well as sex-hormone-independent epigenetic mechanisms could play a crucial role in developing effective and sex specific cardiovascular therapeutics. Existing research highlights significant disparities in sex hormones, epigenetic regulators, and...
Source: Canadian Journal of Physiology and Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Charan Thej Raj Kishore Source Type: research

Impact of biological sex on valvular heart disease, interventions, and outcomes
Can J Physiol Pharmacol. 2024 Mar 1. doi: 10.1139/cjpp-2023-0390. Online ahead of print.ABSTRACTValvular heart disease (VHD) is common, affecting >14% of individuals age >75, and is associated with morbidity, including heart failure and arrhythmia, and risk of early mortality. Increasingly, important sex differences are being found between men and women with VHD. These sex differences can involve the epidemiology, pathophysiology, presentation, diagnosis, and outcomes of the disease. Women are often disadvantaged, and female sex has been shown to be associated with delayed diagnosis and inferior outcomes in various f...
Source: Canadian Journal of Physiology and Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Evan J Wiens Kristal Kawa Malek Kass Ashish H Shah Source Type: research

Tribute-Dr. Pawan K. Singal
Can J Physiol Pharmacol. 2024 Feb 28. doi: 10.1139/cjpp-2024-0046. Online ahead of print.NO ABSTRACTPMID:38415758 | DOI:10.1139/cjpp-2024-0046 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - February 28, 2024 Category: Drugs & Pharmacology Source Type: research

Cardioprotective Effects of Losartan and Diminazene against the Ischemia/Reperfusion Injury in Hyperthyroidism Rats
Can J Physiol Pharmacol. 2024 Feb 20. doi: 10.1139/cjpp-2023-0122. Online ahead of print.ABSTRACTHyperthyroidism is a condition where the thyroid gland produces high levels of thyroid hormone. Heart diseases are one of the main complications of hyperthyroidism. Several studies have shown that losartan (LOS) and diminazene aceturate (DIZE) possess cardioprotection effects against cardiac hypertrophy, ischemic heart disease, and heart failure. The research aimed to investigate the cardioprotection of LOS, DIZE, and their combination in the case of levothyroxine-induced cardiomyopathy in rats. Hyperthyroidism was induced by l...
Source: Canadian Journal of Physiology and Pharmacology - February 20, 2024 Category: Drugs & Pharmacology Authors: Mosayeb Pashaei Mahvash Hesari Dareuosh Shackebaei Aliashraf Godini Source Type: research