Canadian Journal of Physiology and Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Tribute-Dr. Pawan K. Singal
Can J Physiol Pharmacol. 2024 Feb 28. doi: 10.1139/cjpp-2024-0046. Online ahead of print.NO ABSTRACTPMID:38415758 | DOI:10.1139/cjpp-2024-0046 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - February 28, 2024 Category: Drugs & Pharmacology Source Type: research

Cardioprotective Effects of Losartan and Diminazene against the Ischemia/Reperfusion Injury in Hyperthyroidism Rats
Can J Physiol Pharmacol. 2024 Feb 20. doi: 10.1139/cjpp-2023-0122. Online ahead of print.ABSTRACTHyperthyroidism is a condition where the thyroid gland produces high levels of thyroid hormone. Heart diseases are one of the main complications of hyperthyroidism. Several studies have shown that losartan (LOS) and diminazene aceturate (DIZE) possess cardioprotection effects against cardiac hypertrophy, ischemic heart disease, and heart failure. The research aimed to investigate the cardioprotection of LOS, DIZE, and their combination in the case of levothyroxine-induced cardiomyopathy in rats. Hyperthyroidism was induced by l...
Source: Canadian Journal of Physiology and Pharmacology - February 20, 2024 Category: Drugs & Pharmacology Authors: Mosayeb Pashaei Mahvash Hesari Dareuosh Shackebaei Aliashraf Godini Source Type: research

Targeting the vivid facets of apolipoproteins as a cardiovascular risk factor in rheumatoid arthritis
Can J Physiol Pharmacol. 2024 Feb 9. doi: 10.1139/cjpp-2023-0259. Online ahead of print.ABSTRACTMostly, cardiovascular diseases are blamed for casualties in rheumatoid arthritis (RA) patients. Customarily, dyslipidemia is probably the most prevalent underlying cause of untimely demise in people suffering from RA as it hastens the expansion of atherosclerosis. The engagement of inflammatory cytokines like tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), etc., is crucial in the progression and proliferation of both RA and abnormal lipid parameters. Thus, lipid abnormalities should be monitored f...
Source: Canadian Journal of Physiology and Pharmacology - February 9, 2024 Category: Drugs & Pharmacology Authors: Aditi Sharma Chakshu Sharma Lalit Sharma Pranay Wal Preeti Mishra Nitin Sachdeva Shivam Yadav Celia Vargas De-La Cruz Sandeep Arora Vetriselvan Subramaniyan Ravi Rawat Tapan Behl Mukesh Nandave Source Type: research

Effects of prenatal dexamethasone exposure on adult C57BL/6J mouse metabolism and oxidative stress
This study investigated the effects prenatal dexamethasone exposure had on adult offspring cardiac and liver metabolism and oxidative stress. Pregnant C57BL/6 mice received a dose of 0.4 mg/kg dexamethasone on gestational days 15-17. Once pups were approximately 7 months old, glucose uptake was determined using positron emission tomography and insulin resistance (IR) was determined by homeostatic model assessment (HOMA) IR calculation. Oxidative stress was assessed by measuring 4-hydroxynonenal protein adduct formation and total reactive oxygen species. Female dexamethasone group had significantly increased glucose uptake ...
Source: Canadian Journal of Physiology and Pharmacology - February 8, 2024 Category: Drugs & Pharmacology Authors: A S Nemec-Bakk J Bel S Niccoli D R Boreham T C Tai S J Lees N Khaper Source Type: research

The Influence of Estrogen on Myocardial Post-Translational Modifications and Cardiac Function in Women
Can J Physiol Pharmacol. 2024 Jan 24. doi: 10.1139/cjpp-2023-0412. Online ahead of print.ABSTRACTThe lifetime risk of heart failure (HF) is comparable in men and women; nevertheless, disparities exist in our understanding of how HF differs between sexes. Several differences in cardiac physiology exist between men and women including the propensity to develop specific HF phenotypes. Men are more likely to be diagnosed with HF failure with reduced ejection fraction, while women have a greater propensity to develop HF with preserved ejection fraction. The mechanisms responsible for these differences remain unclear. Post-trans...
Source: Canadian Journal of Physiology and Pharmacology - January 24, 2024 Category: Drugs & Pharmacology Authors: Samantha K Shorthill Timothy L M Jones Kathleen C Woulfe Brian D Cherrington Danielle R Bruns Source Type: research