Canadian Journal of Physiology and Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Butorphanol inhibits androgen biosynthesis and metabolism in rat immature Leydig cells in vitro
In conclusion, butorphanol may have side effects of inhibiting androgen biosynthesis and metabolism in Leydig cells.PMID:38258745 | DOI:10.1139/cjpp-2023-0191 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - January 23, 2024 Category: Drugs & Pharmacology Authors: Changchang Li Lei Shi Ming Su Xiaoheng Li Qiqi Zhu Ren-Shan Ge Huitao Li Source Type: research

Stem cell therapy for cardiac regeneration: past, present, and future
Can J Physiol Pharmacol. 2024 Jan 16. doi: 10.1139/cjpp-2023-0202. Online ahead of print.ABSTRACTCardiac disorders remain the leading cause of mortality worldwide. Current clinical strategies, including drug therapy, surgical interventions, and organ transplantation offer limited benefits to patients without regenerating the damaged myocardium. Over the past decade, stem cell therapy has generated a keen interest owing to its unique self-renewal and immune privileged characteristics. Furthermore, the ability of stem cells to differentiate into specialized cell types, has made them a popular therapeutic tool against various...
Source: Canadian Journal of Physiology and Pharmacology - January 16, 2024 Category: Drugs & Pharmacology Authors: Jaideep Kaur Gill Sargun Kaur Rehsia Elika Verma Niketa Sareen Sanjiv Dhingra Source Type: research

Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells
Can J Physiol Pharmacol. 2024 Jan 10. doi: 10.1139/cjpp-2023-0282. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) are the leading causes of morbidity and mortality worldwide. The escalating global occurrence of obesity and diabetes mellitus (DM) has led to a significant upsurge in individuals afflicted with CVDs. As the prevalence of CVDs continues to rise, it is becoming increasingly important to identify the underlying cellular and molecular mechanisms that contribute to their development and progression, which will help discover novel therapeutic avenues. Adipose tissue (AT) is a connective tissue that pla...
Source: Canadian Journal of Physiology and Pharmacology - January 10, 2024 Category: Drugs & Pharmacology Authors: Megan B Meechem Anshul S Jadli Vaibhav B Patel Source Type: research

Note of appreciation
Can J Physiol Pharmacol. 2024 Jan 1;102(1):i. doi: 10.1139/cjpp-2023-0346.NO ABSTRACTPMID:38164926 | DOI:10.1139/cjpp-2023-0346 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - January 2, 2024 Category: Drugs & Pharmacology Source Type: research

Formation of a border ischemic zone depends on plasma potassium concentration
Can J Physiol Pharmacol. 2023 Dec 20. doi: 10.1139/cjpp-2023-0304. Online ahead of print.ABSTRACTExtracellular potassium concentration might modify electrophysiological properties in the border zone (BZ) of ischemic myocardium. We evaluated the depolarization and repolarization characteristics across the ischemic-normal border under [K+] variation. 64-lead epicardial mapping was performed in 26 rats ([K+] 2.3-6.4 mM) in a model of acute ischemia/reperfusion. The animals with [K+]<4.7 mM (low-normal potassium) had an ischemic zone with ST-segment elevation and activation delay, a BZ with ST-segment elevation and no activ...
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Olesya Gennadievna Bernikova Aleksandra Durkina Mikhail Gonotkov Elena Minnebaeva Natalia Arteyeva Jan E Azarov Source Type: research

Azilsartan Prevents Muscle Loss and Fast to Slow-twitch Muscle Fibre Shift in Natural Ageing Sarcopenic Rats
In conclusion, the present findings showed that AZL could be an effective intervention in treating age-related muscle impairments.PMID:38118126 | DOI:10.1139/cjpp-2023-0265 (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - December 20, 2023 Category: Drugs & Pharmacology Authors: Priyanka Prajapati Anand Kumar Shubhada Mangulkar D R Chaple Shubhini A Saraf Sapana Kushwaha Source Type: research