Sex-specific effects of frailty on cardiac structure and function: Insights from preclinical models
Can J Physiol Pharmacol. 2024 Mar 15. doi: 10.1139/cjpp-2024-0009. Online ahead of print.ABSTRACTAdvanced age is an independent risk factor for cardiovascular diseases in both sexes. This is thought to be due, in part, to age-dependent cellular, structural, and functional changes in the heart, a process known as cardiac aging. An emerging view is that cardiac aging leads to the accumulation of cellular and subcellular deficits that increase susceptibility to cardiovascular diseases. Still, people age at different rates, with those aging rapidly considered frail. Evidence suggests that frailty, rather than simply age, is a ...
Source: Canadian Journal of Physiology and Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Elise S Bisset Susan E Howlett Source Type: research

Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women
Can J Physiol Pharmacol. 2024 Mar 15. doi: 10.1139/cjpp-2023-0420. Online ahead of print.ABSTRACTCardiovascular disease (CVD) remains the number one cause of death worldwide. Women are at increased risk of death from CVD, but the mechanisms for how and why this occurs remain elusive. One subset of women who are exceptionally vulnerable to CVD are those with rheumatic diseases (RDs). Indeed, women account for 80% of all RDs, disorders that encompass a broad range of autoimmune and autoinflammatory diseases that lead to chronic inflammation and pathology. The clear association of increased CVD risk in women with RD is though...
Source: Canadian Journal of Physiology and Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Samantha Le Sommer Maria Irene Kontaridis Source Type: research

Sex-specific effects of frailty on cardiac structure and function: Insights from preclinical models
Can J Physiol Pharmacol. 2024 Mar 15. doi: 10.1139/cjpp-2024-0009. Online ahead of print.ABSTRACTAdvanced age is an independent risk factor for cardiovascular diseases in both sexes. This is thought to be due, in part, to age-dependent cellular, structural, and functional changes in the heart, a process known as cardiac aging. An emerging view is that cardiac aging leads to the accumulation of cellular and subcellular deficits that increase susceptibility to cardiovascular diseases. Still, people age at different rates, with those aging rapidly considered frail. Evidence suggests that frailty, rather than simply age, is a ...
Source: Canadian Journal of Physiology and Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Elise S Bisset Susan E Howlett Source Type: research

Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women
Can J Physiol Pharmacol. 2024 Mar 15. doi: 10.1139/cjpp-2023-0420. Online ahead of print.ABSTRACTCardiovascular disease (CVD) remains the number one cause of death worldwide. Women are at increased risk of death from CVD, but the mechanisms for how and why this occurs remain elusive. One subset of women who are exceptionally vulnerable to CVD are those with rheumatic diseases (RDs). Indeed, women account for 80% of all RDs, disorders that encompass a broad range of autoimmune and autoinflammatory diseases that lead to chronic inflammation and pathology. The clear association of increased CVD risk in women with RD is though...
Source: Canadian Journal of Physiology and Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Samantha Le Sommer Maria Irene Kontaridis Source Type: research

Sex-specific effects of frailty on cardiac structure and function: Insights from preclinical models
Can J Physiol Pharmacol. 2024 Mar 15. doi: 10.1139/cjpp-2024-0009. Online ahead of print.ABSTRACTAdvanced age is an independent risk factor for cardiovascular diseases in both sexes. This is thought to be due, in part, to age-dependent cellular, structural, and functional changes in the heart, a process known as cardiac aging. An emerging view is that cardiac aging leads to the accumulation of cellular and subcellular deficits that increase susceptibility to cardiovascular diseases. Still, people age at different rates, with those aging rapidly considered frail. Evidence suggests that frailty, rather than simply age, is a ...
Source: Canadian Journal of Physiology and Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Elise S Bisset Susan E Howlett Source Type: research

Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women
Can J Physiol Pharmacol. 2024 Mar 15. doi: 10.1139/cjpp-2023-0420. Online ahead of print.ABSTRACTCardiovascular disease (CVD) remains the number one cause of death worldwide. Women are at increased risk of death from CVD, but the mechanisms for how and why this occurs remain elusive. One subset of women who are exceptionally vulnerable to CVD are those with rheumatic diseases (RDs). Indeed, women account for 80% of all RDs, disorders that encompass a broad range of autoimmune and autoinflammatory diseases that lead to chronic inflammation and pathology. The clear association of increased CVD risk in women with RD is though...
Source: Canadian Journal of Physiology and Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Samantha Le Sommer Maria Irene Kontaridis Source Type: research

Sex-specific effects of frailty on cardiac structure and function: Insights from preclinical models
Can J Physiol Pharmacol. 2024 Mar 15. doi: 10.1139/cjpp-2024-0009. Online ahead of print.ABSTRACTAdvanced age is an independent risk factor for cardiovascular diseases in both sexes. This is thought to be due, in part, to age-dependent cellular, structural, and functional changes in the heart, a process known as cardiac aging. An emerging view is that cardiac aging leads to the accumulation of cellular and subcellular deficits that increase susceptibility to cardiovascular diseases. Still, people age at different rates, with those aging rapidly considered frail. Evidence suggests that frailty, rather than simply age, is a ...
Source: Canadian Journal of Physiology and Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Elise S Bisset Susan E Howlett Source Type: research

Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women
Can J Physiol Pharmacol. 2024 Mar 15. doi: 10.1139/cjpp-2023-0420. Online ahead of print.ABSTRACTCardiovascular disease (CVD) remains the number one cause of death worldwide. Women are at increased risk of death from CVD, but the mechanisms for how and why this occurs remain elusive. One subset of women who are exceptionally vulnerable to CVD are those with rheumatic diseases (RDs). Indeed, women account for 80% of all RDs, disorders that encompass a broad range of autoimmune and autoinflammatory diseases that lead to chronic inflammation and pathology. The clear association of increased CVD risk in women with RD is though...
Source: Canadian Journal of Physiology and Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Samantha Le Sommer Maria Irene Kontaridis Source Type: research

Sex-specific effects of frailty on cardiac structure and function: Insights from preclinical models
Can J Physiol Pharmacol. 2024 Mar 15. doi: 10.1139/cjpp-2024-0009. Online ahead of print.ABSTRACTAdvanced age is an independent risk factor for cardiovascular diseases in both sexes. This is thought to be due, in part, to age-dependent cellular, structural, and functional changes in the heart, a process known as cardiac aging. An emerging view is that cardiac aging leads to the accumulation of cellular and subcellular deficits that increase susceptibility to cardiovascular diseases. Still, people age at different rates, with those aging rapidly considered frail. Evidence suggests that frailty, rather than simply age, is a ...
Source: Canadian Journal of Physiology and Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Elise S Bisset Susan E Howlett Source Type: research

Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women
Can J Physiol Pharmacol. 2024 Mar 15. doi: 10.1139/cjpp-2023-0420. Online ahead of print.ABSTRACTCardiovascular disease (CVD) remains the number one cause of death worldwide. Women are at increased risk of death from CVD, but the mechanisms for how and why this occurs remain elusive. One subset of women who are exceptionally vulnerable to CVD are those with rheumatic diseases (RDs). Indeed, women account for 80% of all RDs, disorders that encompass a broad range of autoimmune and autoinflammatory diseases that lead to chronic inflammation and pathology. The clear association of increased CVD risk in women with RD is though...
Source: Canadian Journal of Physiology and Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Samantha Le Sommer Maria Irene Kontaridis Source Type: research

Sex-specific effects of frailty on cardiac structure and function: Insights from preclinical models
Can J Physiol Pharmacol. 2024 Mar 15. doi: 10.1139/cjpp-2024-0009. Online ahead of print.ABSTRACTAdvanced age is an independent risk factor for cardiovascular diseases in both sexes. This is thought to be due, in part, to age-dependent cellular, structural, and functional changes in the heart, a process known as cardiac aging. An emerging view is that cardiac aging leads to the accumulation of cellular and subcellular deficits that increase susceptibility to cardiovascular diseases. Still, people age at different rates, with those aging rapidly considered frail. Evidence suggests that frailty, rather than simply age, is a ...
Source: Canadian Journal of Physiology and Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Elise S Bisset Susan E Howlett Source Type: research

Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women
Can J Physiol Pharmacol. 2024 Mar 15. doi: 10.1139/cjpp-2023-0420. Online ahead of print.ABSTRACTCardiovascular disease (CVD) remains the number one cause of death worldwide. Women are at increased risk of death from CVD, but the mechanisms for how and why this occurs remain elusive. One subset of women who are exceptionally vulnerable to CVD are those with rheumatic diseases (RDs). Indeed, women account for 80% of all RDs, disorders that encompass a broad range of autoimmune and autoinflammatory diseases that lead to chronic inflammation and pathology. The clear association of increased CVD risk in women with RD is though...
Source: Canadian Journal of Physiology and Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Samantha Le Sommer Maria Irene Kontaridis Source Type: research

Sex-specific effects of frailty on cardiac structure and function: Insights from preclinical models
Can J Physiol Pharmacol. 2024 Mar 15. doi: 10.1139/cjpp-2024-0009. Online ahead of print.ABSTRACTAdvanced age is an independent risk factor for cardiovascular diseases in both sexes. This is thought to be due, in part, to age-dependent cellular, structural, and functional changes in the heart, a process known as cardiac aging. An emerging view is that cardiac aging leads to the accumulation of cellular and subcellular deficits that increase susceptibility to cardiovascular diseases. Still, people age at different rates, with those aging rapidly considered frail. Evidence suggests that frailty, rather than simply age, is a ...
Source: Canadian Journal of Physiology and Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Elise S Bisset Susan E Howlett Source Type: research

Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women
Can J Physiol Pharmacol. 2024 Mar 15. doi: 10.1139/cjpp-2023-0420. Online ahead of print.ABSTRACTCardiovascular disease (CVD) remains the number one cause of death worldwide. Women are at increased risk of death from CVD, but the mechanisms for how and why this occurs remain elusive. One subset of women who are exceptionally vulnerable to CVD are those with rheumatic diseases (RDs). Indeed, women account for 80% of all RDs, disorders that encompass a broad range of autoimmune and autoinflammatory diseases that lead to chronic inflammation and pathology. The clear association of increased CVD risk in women with RD is though...
Source: Canadian Journal of Physiology and Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Samantha Le Sommer Maria Irene Kontaridis Source Type: research

Sex-specific effects of frailty on cardiac structure and function: Insights from preclinical models
Can J Physiol Pharmacol. 2024 Mar 15. doi: 10.1139/cjpp-2024-0009. Online ahead of print.ABSTRACTAdvanced age is an independent risk factor for cardiovascular diseases in both sexes. This is thought to be due, in part, to age-dependent cellular, structural, and functional changes in the heart, a process known as cardiac aging. An emerging view is that cardiac aging leads to the accumulation of cellular and subcellular deficits that increase susceptibility to cardiovascular diseases. Still, people age at different rates, with those aging rapidly considered frail. Evidence suggests that frailty, rather than simply age, is a ...
Source: Canadian Journal of Physiology and Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Elise S Bisset Susan E Howlett Source Type: research