Alpha-Lipoic Acid Enhances Ischemic Postconditioning-Mediated Improvement of Myocardial Infarction and Apoptosis in Diabetic Rats with Ischemia/Reperfusion Injury
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0044. Online ahead of print.ABSTRACTThis work evaluated the combined effects of alpha-lipoic acid (ALA) and ischemic-postconditioning (Post) on myocardial infarction and cell death in rats with chronic type-2 diabetes following ischemia/reperfusion injury. The rats received a high-fat diet and were given one intraperitoneal injection of 35 mg/kg streptozotocin to induce chronic diabetes. They were then pretreated with ALA (100 mg/kg/day, orally) for five weeks before undergoing I/R insult. The hearts experienced 35-minute regional ischemia through ligating the le...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Sanaz Gholami Reza Badalzadeh Alireza AliHemmati Source Type: research

Effects of a high-fat low-carbohydrate diet under different energy conditions on glucose homeostasis and fatty liver development in rats and on gluconeogenesis in the isolated perfused liver
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0071. Online ahead of print.ABSTRACTThe beneficial effects of high-fat, low-carbohydrate diets (HFLC) on glucose metabolism have been questioned and its effects on liver metabolism are not totally clear. The aim of this work was to investigate the effects of a HFLC diet under different energy conditions on glucose homeostasis, fatty liver development and hepatic gluconeogenesis using the isolated perfused rat liver. HFLC diet (79% fat, 19% protein, and 2% carbohydrates in Kcal%) was administered to rats for four weeks under three conditions: ad libitum (hypercalo...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Mateus Jos é de Oliveira Evelyn Silva Moreira Naiara Cristina Lucredi Carla Indianara Bonetti Anacharis Babeto de S á-Nakanishi Jurandir Fernando Comar Adelar Bracht L ívia Bracht Source Type: research

Alpha-Lipoic Acid Enhances Ischemic Postconditioning-Mediated Improvement of Myocardial Infarction and Apoptosis in Diabetic Rats with Ischemia/Reperfusion Injury
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0044. Online ahead of print.ABSTRACTThis work evaluated the combined effects of alpha-lipoic acid (ALA) and ischemic-postconditioning (Post) on myocardial infarction and cell death in rats with chronic type-2 diabetes following ischemia/reperfusion injury. The rats received a high-fat diet and were given one intraperitoneal injection of 35 mg/kg streptozotocin to induce chronic diabetes. They were then pretreated with ALA (100 mg/kg/day, orally) for five weeks before undergoing I/R insult. The hearts experienced 35-minute regional ischemia through ligating the le...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Sanaz Gholami Reza Badalzadeh Alireza AliHemmati Source Type: research

Effects of a high-fat low-carbohydrate diet under different energy conditions on glucose homeostasis and fatty liver development in rats and on gluconeogenesis in the isolated perfused liver
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0071. Online ahead of print.ABSTRACTThe beneficial effects of high-fat, low-carbohydrate diets (HFLC) on glucose metabolism have been questioned and its effects on liver metabolism are not totally clear. The aim of this work was to investigate the effects of a HFLC diet under different energy conditions on glucose homeostasis, fatty liver development and hepatic gluconeogenesis using the isolated perfused rat liver. HFLC diet (79% fat, 19% protein, and 2% carbohydrates in Kcal%) was administered to rats for four weeks under three conditions: ad libitum (hypercalo...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Mateus Jos é de Oliveira Evelyn Silva Moreira Naiara Cristina Lucredi Carla Indianara Bonetti Anacharis Babeto de S á-Nakanishi Jurandir Fernando Comar Adelar Bracht L ívia Bracht Source Type: research

Alpha-Lipoic Acid Enhances Ischemic Postconditioning-Mediated Improvement of Myocardial Infarction and Apoptosis in Diabetic Rats with Ischemia/Reperfusion Injury
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0044. Online ahead of print.ABSTRACTThis work evaluated the combined effects of alpha-lipoic acid (ALA) and ischemic-postconditioning (Post) on myocardial infarction and cell death in rats with chronic type-2 diabetes following ischemia/reperfusion injury. The rats received a high-fat diet and were given one intraperitoneal injection of 35 mg/kg streptozotocin to induce chronic diabetes. They were then pretreated with ALA (100 mg/kg/day, orally) for five weeks before undergoing I/R insult. The hearts experienced 35-minute regional ischemia through ligating the le...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Sanaz Gholami Reza Badalzadeh Alireza AliHemmati Source Type: research

Effects of a high-fat low-carbohydrate diet under different energy conditions on glucose homeostasis and fatty liver development in rats and on gluconeogenesis in the isolated perfused liver
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0071. Online ahead of print.ABSTRACTThe beneficial effects of high-fat, low-carbohydrate diets (HFLC) on glucose metabolism have been questioned and its effects on liver metabolism are not totally clear. The aim of this work was to investigate the effects of a HFLC diet under different energy conditions on glucose homeostasis, fatty liver development and hepatic gluconeogenesis using the isolated perfused rat liver. HFLC diet (79% fat, 19% protein, and 2% carbohydrates in Kcal%) was administered to rats for four weeks under three conditions: ad libitum (hypercalo...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Mateus Jos é de Oliveira Evelyn Silva Moreira Naiara Cristina Lucredi Carla Indianara Bonetti Anacharis Babeto de S á-Nakanishi Jurandir Fernando Comar Adelar Bracht L ívia Bracht Source Type: research

Alpha-Lipoic Acid Enhances Ischemic Postconditioning-Mediated Improvement of Myocardial Infarction and Apoptosis in Diabetic Rats with Ischemia/Reperfusion Injury
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0044. Online ahead of print.ABSTRACTThis work evaluated the combined effects of alpha-lipoic acid (ALA) and ischemic-postconditioning (Post) on myocardial infarction and cell death in rats with chronic type-2 diabetes following ischemia/reperfusion injury. The rats received a high-fat diet and were given one intraperitoneal injection of 35 mg/kg streptozotocin to induce chronic diabetes. They were then pretreated with ALA (100 mg/kg/day, orally) for five weeks before undergoing I/R insult. The hearts experienced 35-minute regional ischemia through ligating the le...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Sanaz Gholami Reza Badalzadeh Alireza AliHemmati Source Type: research

Effects of a high-fat low-carbohydrate diet under different energy conditions on glucose homeostasis and fatty liver development in rats and on gluconeogenesis in the isolated perfused liver
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0071. Online ahead of print.ABSTRACTThe beneficial effects of high-fat, low-carbohydrate diets (HFLC) on glucose metabolism have been questioned and its effects on liver metabolism are not totally clear. The aim of this work was to investigate the effects of a HFLC diet under different energy conditions on glucose homeostasis, fatty liver development and hepatic gluconeogenesis using the isolated perfused rat liver. HFLC diet (79% fat, 19% protein, and 2% carbohydrates in Kcal%) was administered to rats for four weeks under three conditions: ad libitum (hypercalo...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Mateus Jos é de Oliveira Evelyn Silva Moreira Naiara Cristina Lucredi Carla Indianara Bonetti Anacharis Babeto de S á-Nakanishi Jurandir Fernando Comar Adelar Bracht L ívia Bracht Source Type: research

Alpha-Lipoic Acid Enhances Ischemic Postconditioning-Mediated Improvement of Myocardial Infarction and Apoptosis in Diabetic Rats with Ischemia/Reperfusion Injury
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0044. Online ahead of print.ABSTRACTThis work evaluated the combined effects of alpha-lipoic acid (ALA) and ischemic-postconditioning (Post) on myocardial infarction and cell death in rats with chronic type-2 diabetes following ischemia/reperfusion injury. The rats received a high-fat diet and were given one intraperitoneal injection of 35 mg/kg streptozotocin to induce chronic diabetes. They were then pretreated with ALA (100 mg/kg/day, orally) for five weeks before undergoing I/R insult. The hearts experienced 35-minute regional ischemia through ligating the le...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Sanaz Gholami Reza Badalzadeh Alireza AliHemmati Source Type: research

Effects of a high-fat low-carbohydrate diet under different energy conditions on glucose homeostasis and fatty liver development in rats and on gluconeogenesis in the isolated perfused liver
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0071. Online ahead of print.ABSTRACTThe beneficial effects of high-fat, low-carbohydrate diets (HFLC) on glucose metabolism have been questioned and its effects on liver metabolism are not totally clear. The aim of this work was to investigate the effects of a HFLC diet under different energy conditions on glucose homeostasis, fatty liver development and hepatic gluconeogenesis using the isolated perfused rat liver. HFLC diet (79% fat, 19% protein, and 2% carbohydrates in Kcal%) was administered to rats for four weeks under three conditions: ad libitum (hypercalo...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Mateus Jos é de Oliveira Evelyn Silva Moreira Naiara Cristina Lucredi Carla Indianara Bonetti Anacharis Babeto de S á-Nakanishi Jurandir Fernando Comar Adelar Bracht L ívia Bracht Source Type: research

Alpha-Lipoic Acid Enhances Ischemic Postconditioning-Mediated Improvement of Myocardial Infarction and Apoptosis in Diabetic Rats with Ischemia/Reperfusion Injury
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0044. Online ahead of print.ABSTRACTThis work evaluated the combined effects of alpha-lipoic acid (ALA) and ischemic-postconditioning (Post) on myocardial infarction and cell death in rats with chronic type-2 diabetes following ischemia/reperfusion injury. The rats received a high-fat diet and were given one intraperitoneal injection of 35 mg/kg streptozotocin to induce chronic diabetes. They were then pretreated with ALA (100 mg/kg/day, orally) for five weeks before undergoing I/R insult. The hearts experienced 35-minute regional ischemia through ligating the le...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Sanaz Gholami Reza Badalzadeh Alireza AliHemmati Source Type: research

Effects of a high-fat low-carbohydrate diet under different energy conditions on glucose homeostasis and fatty liver development in rats and on gluconeogenesis in the isolated perfused liver
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0071. Online ahead of print.ABSTRACTThe beneficial effects of high-fat, low-carbohydrate diets (HFLC) on glucose metabolism have been questioned and its effects on liver metabolism are not totally clear. The aim of this work was to investigate the effects of a HFLC diet under different energy conditions on glucose homeostasis, fatty liver development and hepatic gluconeogenesis using the isolated perfused rat liver. HFLC diet (79% fat, 19% protein, and 2% carbohydrates in Kcal%) was administered to rats for four weeks under three conditions: ad libitum (hypercalo...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Mateus Jos é de Oliveira Evelyn Silva Moreira Naiara Cristina Lucredi Carla Indianara Bonetti Anacharis Babeto de S á-Nakanishi Jurandir Fernando Comar Adelar Bracht L ívia Bracht Source Type: research

Alpha-Lipoic Acid Enhances Ischemic Postconditioning-Mediated Improvement of Myocardial Infarction and Apoptosis in Diabetic Rats with Ischemia/Reperfusion Injury
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0044. Online ahead of print.ABSTRACTThis work evaluated the combined effects of alpha-lipoic acid (ALA) and ischemic-postconditioning (Post) on myocardial infarction and cell death in rats with chronic type-2 diabetes following ischemia/reperfusion injury. The rats received a high-fat diet and were given one intraperitoneal injection of 35 mg/kg streptozotocin to induce chronic diabetes. They were then pretreated with ALA (100 mg/kg/day, orally) for five weeks before undergoing I/R insult. The hearts experienced 35-minute regional ischemia through ligating the le...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Sanaz Gholami Reza Badalzadeh Alireza AliHemmati Source Type: research

Effects of a high-fat low-carbohydrate diet under different energy conditions on glucose homeostasis and fatty liver development in rats and on gluconeogenesis in the isolated perfused liver
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0071. Online ahead of print.ABSTRACTThe beneficial effects of high-fat, low-carbohydrate diets (HFLC) on glucose metabolism have been questioned and its effects on liver metabolism are not totally clear. The aim of this work was to investigate the effects of a HFLC diet under different energy conditions on glucose homeostasis, fatty liver development and hepatic gluconeogenesis using the isolated perfused rat liver. HFLC diet (79% fat, 19% protein, and 2% carbohydrates in Kcal%) was administered to rats for four weeks under three conditions: ad libitum (hypercalo...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Mateus Jos é de Oliveira Evelyn Silva Moreira Naiara Cristina Lucredi Carla Indianara Bonetti Anacharis Babeto de S á-Nakanishi Jurandir Fernando Comar Adelar Bracht L ívia Bracht Source Type: research

Alpha-Lipoic Acid Enhances Ischemic Postconditioning-Mediated Improvement of Myocardial Infarction and Apoptosis in Diabetic Rats with Ischemia/Reperfusion Injury
Can J Physiol Pharmacol. 2023 Jul 31. doi: 10.1139/cjpp-2023-0044. Online ahead of print.ABSTRACTThis work evaluated the combined effects of alpha-lipoic acid (ALA) and ischemic-postconditioning (Post) on myocardial infarction and cell death in rats with chronic type-2 diabetes following ischemia/reperfusion injury. The rats received a high-fat diet and were given one intraperitoneal injection of 35 mg/kg streptozotocin to induce chronic diabetes. They were then pretreated with ALA (100 mg/kg/day, orally) for five weeks before undergoing I/R insult. The hearts experienced 35-minute regional ischemia through ligating the le...
Source: Canadian Journal of Physiology and Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Sanaz Gholami Reza Badalzadeh Alireza AliHemmati Source Type: research