Canadian Journal of Physiology and Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Unveiling the antibacterial and antioxidant potential of < em > Hedera helix < /em > leaf extracts: recent findings
In this study, the ethanolic extract from H. helix leaves was investigated for its total polyphenolic and flavonoid contents, as well as its antioxidant and antibacterial properties. The aim was to evaluate its potential for controlling certain infections by screening its antibacterial activity against selected pathogenic bacteria. The total phenolic and flavonoid contents of the extract were determined using colorimetric methods. The antioxidant activity was assessed through two assay methods: the 1, 1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging activity and the reducing power ferric reducing/antioxidant pow...
Source: Canadian Journal of Physiology and Pharmacology - October 18, 2023 Category: Drugs & Pharmacology Authors: Khaled Qabaha Jehad Abbadi Reem Yaghmour Thameen Hijawi Saleh A Naser Fuad Al-Rimawi Source Type: research

PRIMA-1 synergizes olaparib-induced cell death in p53 mutant triple negative human breast cancer cell line via restoring p53 function, arresting cell cycle, and inducing apoptosis
This study concerned with assessing the effect of restoring p53 using PRIMA-1 on the anti-cancer activity of olaparib against TP53-mutant triple negative breast cancer (TNBC) cells and exploring the optimum synergistic concentrations and the underlying mechanism. Human BC cell lines, MDA-MB-231 with mutated TP53 gene, and MCF-7 with wild-type TP53 gene were treated with olaparib and/or PRIMA-1. The IC50 value for olaparib was significantly decreased by PRIMA-1 in MDA-MB-231 cells compared to MCF-7 cells. Contrary to MCF-7 cells, co-treatment with olaparib and PRIMA-1 had a synergistic anti-proliferative effect in MDA-MB-23...
Source: Canadian Journal of Physiology and Pharmacology - October 11, 2023 Category: Drugs & Pharmacology Authors: Mohamed Zaza Mohammed H Rashed Hesham Elrefaey Memy H Hassan Osama M Abo-Salem El-Sayed M El-Sayed Source Type: research

The impact of ionizing radiation compared to drug-induced immunological changes
This study shows the impact of acute low-dose IR on crucial cytokines involved in cell-mediated immunity. The immunomodulatory effects of 0.25 and 0.5 Gray (Gy) gamma rays and standard immunomodulatory drugs (cyclophosphamide) on blood counts and significant pro-inflammatory cytokines implicated in various inflammatory conditions were tested in 20 rats. Examined was the effect of acute low doses on critical cytokines, which could be utilized as an alternative to current immunosuppressive drugs. One day post-irradiation, serum levels of interferon-gamma (INF-γ), tumor necrosis factor-alpha, and interleukin-2/1-beta were me...
Source: Canadian Journal of Physiology and Pharmacology - September 28, 2023 Category: Drugs & Pharmacology Authors: Soha M Hussien Source Type: research