RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway

In conclusion, RAD54B exerts a direct protective effect against DNA damage through enhancing homologous recombination repair in endothelial senescence, resulting in inhibition of the downstream CHK1/p53/p21 pathway, suggesting that RAD54B may be a potential therapeutic target for vascular aging-associated diseases.PMID:37748205 | DOI:10.1139/cjpp-2023-0192

Source: Canadian Journal of Physiology and Pharmacology - September 25, 2023 Category: Drugs & Pharmacology Authors: Yanqi Mai Tong Lin Lili Zhang Wanqi Yang Sitong Liu Minghui Wang Peiqing Liu Zhuoming Li Wenwei Luo Source Type: research