Trehalose enhanced cold atmospheric plasma-mediated cancer treatment
Biomaterials. 2024 Apr 18;309:122582. doi: 10.1016/j.biomaterials.2024.122582. Online ahead of print.ABSTRACTCold atmospheric plasma (CAP) is a unique form of physical plasma that has shown great potential for cancer therapy. CAP uses ionized gas to induce lethal oxidative stress on cancer cells; however, the efficacy of CAP therapy continues to be improved. Here, we report an injectable hydrogel-mediated approach to enhance the anti-tumor efficacy of CAP by regulating the phosphorylation of eIF2α. We discovered that reactive oxygen and nitrogen species (ROS/RNS), two main anti-tumor components in CAP, can lead to lethal ...
Source: Biomaterials - April 28, 2024 Category: Materials Science Authors: Xiaona Cao Tianxu Fang Mo Chen Tianqin Ning Jianyu Li Peter M Siegel Morag Park Zhitong Chen Guojun Chen Source Type: research
Trehalose enhanced cold atmospheric plasma-mediated cancer treatment
Biomaterials. 2024 Apr 18;309:122582. doi: 10.1016/j.biomaterials.2024.122582. Online ahead of print.ABSTRACTCold atmospheric plasma (CAP) is a unique form of physical plasma that has shown great potential for cancer therapy. CAP uses ionized gas to induce lethal oxidative stress on cancer cells; however, the efficacy of CAP therapy continues to be improved. Here, we report an injectable hydrogel-mediated approach to enhance the anti-tumor efficacy of CAP by regulating the phosphorylation of eIF2α. We discovered that reactive oxygen and nitrogen species (ROS/RNS), two main anti-tumor components in CAP, can lead to lethal ...
Source: Biomaterials - April 28, 2024 Category: Materials Science Authors: Xiaona Cao Tianxu Fang Mo Chen Tianqin Ning Jianyu Li Peter M Siegel Morag Park Zhitong Chen Guojun Chen Source Type: research
Deciphering platinum dissolution in neural stimulation electrodes: Electrochemistry or biology?
Biomaterials. 2024 Apr 17;309:122575. doi: 10.1016/j.biomaterials.2024.122575. Online ahead of print.ABSTRACTPlatinum (Pt) is the metal of choice for electrodes in implantable neural prostheses like the cochlear implants, deep brain stimulating devices, and brain-computer interfacing technologies. However, it is well known since the 1970s that Pt dissolution occurs with electrical stimulation. More recent clinical and in vivo studies have shown signs of corrosion in explanted electrode arrays and the presence of Pt-containing particulates in tissue samples. The process of degradation and release of metallic ions and partic...
Source: Biomaterials - April 27, 2024 Category: Materials Science Authors: Dhyey Devashish Shah Paul Carter Mohit Naresh Shivdasani Nicole Fong Wenlu Duan Dorna Esrafilzadeh Laura Anne Poole-Warren Ulises Alejandro Aregueta Robles Source Type: research
Mucus-coated, magnetically-propelled fecal surrogate to mimic fecal shear forces on colonic epithelium
In this report, we created a mucus-coated fecal surrogate that was magnetically propelled to produce a controllable sweeping mechanical stimulation on primary intestinal epithelial cell monolayers. The mucus layer was derived from purified porcine stomach mucins, which were first modified with reactive vinyl sulfone (VS) groups followed by reaction with a thiol crosslinker (PEG-4SH) via a Michael addition click reaction. Formation of mucus hydrogel network was achieved at the optimal mixing ratio at 2.5 % w/v mucin-VS and 0.5 % w/v PEG-4SH. The artificial mucus layer possessed similar properties as the native mucus in term...
Source: Biomaterials - April 27, 2024 Category: Materials Science Authors: Alan S Wang Cecilia Villegas-Novoa Yuli Wang Christopher E Sims Nancy L Allbritton Source Type: research
Polymeric micellar nanoparticles for effective CRISPR/Cas9 genome editing in cancer
Biomaterials. 2024 Apr 17;309:122573. doi: 10.1016/j.biomaterials.2024.122573. Online ahead of print.ABSTRACTThe clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein 9 (Cas9) gene editing has attracted extensive attentions in various fields, however, its clinical application is hindered by the lack of effective and safe delivery system. Herein, we reported a cationic micelle nanoparticle composed of cholesterol-modified branched small molecular PEI (PEI-CHO) and biodegradable PEG-b-polycarbonate block copolymer (PEG-PC), denoted as PEG-PC/PEI-CHO/pCas9, for the CRISPR/Cas9 delivery to realiz...
Source: Biomaterials - April 27, 2024 Category: Materials Science Authors: Yuzhen Li Chun Li Jiachang Yan Ying Liao Chengyuan Qin Lingyin Wang Yi Huang Chuan Yang Jianwei Wang Xin Ding Yi Yan Yang Peiyan Yuan Source Type: research
A ferroptosis amplifier based on triple-enhanced lipid peroxides accumulation strategy for effective pancreatic cancer therapy
Biomaterials. 2024 Apr 21;309:122574. doi: 10.1016/j.biomaterials.2024.122574. Online ahead of print.ABSTRACTAs an iron dependent regulatory cell death process driven by excessive lipid peroxides (LPO), ferroptosis is recognized as a powerful weapon for pancreatic cancer (PC) therapy. However, the tumor microenvironment (TME) with hypoxia and elevated glutathione (GSH) expression not only inhibits LPO production, but also induces glutathione peroxidase 4 (GPX4) mediated LPO clearance, which greatly compromise the therapeutic outcomes of ferroptosis. To address these issues, herein, a novel triple-enhanced ferroptosis ampli...
Source: Biomaterials - April 26, 2024 Category: Materials Science Authors: Mengyao Chen Xiaohan Tong Yanting Sun Chunyan Dong Chen Li Chunhui Wang Minyi Zhang Yixuan Wen Pinting Ye Ruihao Li Jie Wan Shujing Liang Shuo Shi Source Type: research
Wireless breathable face mask sensor for spatiotemporal 2D respiration profiling and respiratory diagnosis
In this study, we introduced an air-permeable, stretchable, and a pixelated pressure sensor that can be integrated into a commercial face mask. The mask sensor showed a strain-independent pressure-sensing performance, providing 2D pressure profiles for exhalation and inhalation. Real-time 2D respiration profiles could monitor various respiratory behaviors, such as oral/nasal breathing, clogged nose, out-of-breath, and coughing. Furthermore, they could detect respiratory diseases, such as rhinitis, sleep apnea, and pneumonia. The 2D respiratory profiling mask sensor is expected to be employed for remote respiration monitori...
Source: Biomaterials - April 26, 2024 Category: Materials Science Authors: Jaehyun Kim Heesung Roh Sungmin Moon Cheonhoo Jeon Seunggoo Baek Woosung Cho Jae-Yoon Sim Unyong Jeong Source Type: research
A ferroptosis amplifier based on triple-enhanced lipid peroxides accumulation strategy for effective pancreatic cancer therapy
Biomaterials. 2024 Apr 21;309:122574. doi: 10.1016/j.biomaterials.2024.122574. Online ahead of print.ABSTRACTAs an iron dependent regulatory cell death process driven by excessive lipid peroxides (LPO), ferroptosis is recognized as a powerful weapon for pancreatic cancer (PC) therapy. However, the tumor microenvironment (TME) with hypoxia and elevated glutathione (GSH) expression not only inhibits LPO production, but also induces glutathione peroxidase 4 (GPX4) mediated LPO clearance, which greatly compromise the therapeutic outcomes of ferroptosis. To address these issues, herein, a novel triple-enhanced ferroptosis ampli...
Source: Biomaterials - April 26, 2024 Category: Materials Science Authors: Mengyao Chen Xiaohan Tong Yanting Sun Chunyan Dong Chen Li Chunhui Wang Minyi Zhang Yixuan Wen Pinting Ye Ruihao Li Jie Wan Shujing Liang Shuo Shi Source Type: research
Wireless breathable face mask sensor for spatiotemporal 2D respiration profiling and respiratory diagnosis
In this study, we introduced an air-permeable, stretchable, and a pixelated pressure sensor that can be integrated into a commercial face mask. The mask sensor showed a strain-independent pressure-sensing performance, providing 2D pressure profiles for exhalation and inhalation. Real-time 2D respiration profiles could monitor various respiratory behaviors, such as oral/nasal breathing, clogged nose, out-of-breath, and coughing. Furthermore, they could detect respiratory diseases, such as rhinitis, sleep apnea, and pneumonia. The 2D respiratory profiling mask sensor is expected to be employed for remote respiration monitori...
Source: Biomaterials - April 26, 2024 Category: Materials Science Authors: Jaehyun Kim Heesung Roh Sungmin Moon Cheonhoo Jeon Seunggoo Baek Woosung Cho Jae-Yoon Sim Unyong Jeong Source Type: research
Corrigendum to 'Engineered cell-laden human protein-based elastomer' [34 (2013), 5496-5505]
Biomaterials. 2024 Apr 24:122572. doi: 10.1016/j.biomaterials.2024.122572. Online ahead of print.NO ABSTRACTPMID:38664162 | DOI:10.1016/j.biomaterials.2024.122572 (Source: Biomaterials)
Source: Biomaterials - April 25, 2024 Category: Materials Science Authors: Nasim Annabi Suzanne M Mithieux Pinar Zorlutuna Gulden Camci-Unal Anthony S Weiss Ali Khademhosseini Source Type: research
Corrigendum to 'Engineered cell-laden human protein-based elastomer' [34 (2013), 5496-5505]
Biomaterials. 2024 Apr 24:122572. doi: 10.1016/j.biomaterials.2024.122572. Online ahead of print.NO ABSTRACTPMID:38664162 | DOI:10.1016/j.biomaterials.2024.122572 (Source: Biomaterials)
Source: Biomaterials - April 25, 2024 Category: Materials Science Authors: Nasim Annabi Suzanne M Mithieux Pinar Zorlutuna Gulden Camci-Unal Anthony S Weiss Ali Khademhosseini Source Type: research
Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy
Biomaterials. 2024 Apr 15;308:122581. doi: 10.1016/j.biomaterials.2024.122581. Online ahead of print.ABSTRACTCancer stem cells (CSCs) characterized by self-renewal, invasiveness, tumorigenicity and resistance to treatment are regarded as the thorniest issues in refractory tumors. We develop a targeted and hierarchical controlled release nano-therapeutic platform (SEED-NPs) that self-identifies and responds to CSC and non-CSC micro-niches of tumors. In non-CSC micro-niche, reactive oxygen species (ROS) trigger the burst release of the chemotherapeutic drug and photosensitizer to kill tumor cells and reduce tumor volume by c...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Yiliang Yang Yiwei Peng Yitian Du Meng Lin Jiajia Li Datong Gao Zhenzhen Yang Wei Wang Yanxia Zhou Xinru Li Taiqiang Yan Xianrong Qi Source Type: research
Implantable CAR T cell factories enhance solid tumor treatment
Biomaterials. 2024 Apr 15;308:122580. doi: 10.1016/j.biomaterials.2024.122580. Online ahead of print.ABSTRACTChimeric Antigen Receptor (CAR) T cell therapy has produced revolutionary success in hematological cancers such as leukemia and lymphoma. Nonetheless, its translation to solid tumors faces challenges due to manufacturing complexities, short-lived in vivo persistence, and transient therapeutic impact. We introduce 'Drydux' - an innovative macroporous biomaterial scaffold designed for rapid, efficient in-situ generation of tumor-specific CAR T cells. Drydux expedites CAR T cell preparation with a mere three-day turnar...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Sharda Pandit Pritha Agarwalla Feifei Song Anton Jansson Gianpietro Dotti Yevgeny Brudno Source Type: research
Beyond surface modification strategies to control infections associated with implanted biomaterials and devices - Addressing the opportunities offered by nanotechnology
Biomaterials. 2024 Apr 16;308:122576. doi: 10.1016/j.biomaterials.2024.122576. Online ahead of print.ABSTRACTBiomaterial-associated infection (BAI) is considered a unique infection due to the presence of a biomaterial yielding frustrated immune-cells, ineffective in clearing local micro-organisms. The involvement of surface-adherent/surface-adapted micro-organisms in BAI, logically points to biomaterial surface-modifications for BAI-control. Biomaterial surface-modification is most suitable for prevention before adhering bacteria have grown into a mature biofilm, while BAI-treatment is virtually impossible through surface-...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Da-Yuan Wang Linzhu Su Kees Poelstra David W Grainger Henny C van der Mei Linqi Shi Henk J Busscher Source Type: research
Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy
Biomaterials. 2024 Apr 15;308:122581. doi: 10.1016/j.biomaterials.2024.122581. Online ahead of print.ABSTRACTCancer stem cells (CSCs) characterized by self-renewal, invasiveness, tumorigenicity and resistance to treatment are regarded as the thorniest issues in refractory tumors. We develop a targeted and hierarchical controlled release nano-therapeutic platform (SEED-NPs) that self-identifies and responds to CSC and non-CSC micro-niches of tumors. In non-CSC micro-niche, reactive oxygen species (ROS) trigger the burst release of the chemotherapeutic drug and photosensitizer to kill tumor cells and reduce tumor volume by c...
Source: Biomaterials - April 19, 2024 Category: Materials Science Authors: Yiliang Yang Yiwei Peng Yitian Du Meng Lin Jiajia Li Datong Gao Zhenzhen Yang Wei Wang Yanxia Zhou Xinru Li Taiqiang Yan Xianrong Qi Source Type: research
