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Passenger Lymphocyte Syndrome as a rare cause of hemolysis in a patient after small intestine transplantation, A case report and review of the literature
Edalat Zarei, Mojtaba Shafiekhani, Nazanin Azadeh, Alireza Shamsaeefar, Mahnaz Lotfi, Mahbube Ahrami, Amirhassan Rabbani, Hamed NikoupourAsian Journal of Transfusion Science 2022 16(1):135-139 Passenger lymphocyte syndrome (PLS) is a well-described phenomenon causing immune hemolytic anemia, mostly in non-ABO identical transplantations. The syndrome occurs when donor lymphocytes produce antibodies against the recipient's red blood cells. Although the syndrome is usually self-limited, further management with blood transfusions, immunosuppression, or plasmapheresis might be needed. A 23-year-old female with AB&#x...
Source: Asian Journal of Transfusion Science - July 30, 2022 Category: Hematology Authors: Edalat Zarei Mojtaba Shafiekhani Nazanin Azadeh Alireza Shamsaeefar Mahnaz Lotfi Mahbube Ahrami Amirhassan Rabbani Hamed Nikoupour Source Type: research

Detection of a weaker subgroup of A in ABO blood group system
Gurika Chopra, Manpreet Kataria, Arshpreet Kaur Batra, Gurkiran kaur, Rajesh KumarAsian Journal of Transfusion Science 2022 16(1):132-134 Testing to detect ABO incompatibility between a donor and potential transfusion recipient is the foundation on which all other pretransfusion testing is based. Sometimes, weak agglutination reactions may be obtained with reagent antibodies due to weak expression of A and B antigens on red blood cell (RBC) surface which may cause a discrepancy in blood group typing. Here, we report a patient showing discrepancy between RBCs (forward) and serum (reverse) typing. After doing detailed analy...
Source: Asian Journal of Transfusion Science - July 30, 2022 Category: Hematology Authors: Gurika Chopra Manpreet Kataria Arshpreet Kaur Batra Gurkiran kaur Rajesh Kumar Source Type: research

Successful management of Methemoglobinemia and G6PD deficiency in a patient posted for surgical excision of branchial cyst
VJ Arun, Anuradha Deorukhkar, Aboobacker Mohamed Rafi, Deepak Charles, Rati Devendra, Susheela J Innah, Prabhakar KedarAsian Journal of Transfusion Science 2022 16(1):128-131 A 27-year-old female patient who came for branchial cyst excision was found to have cyanosis and a saturation gap during preanesthetic check-up and hence she was referred to haematology for further workup. She had a Hb of 9 gm% with all other baseline tests as normal. Blood samples were sent for methaemoglobin estimation and related work up to the National Institute of Immunohematology (NIIH) Mumbai. She was diagnosed as a case of Methemog...
Source: Asian Journal of Transfusion Science - July 30, 2022 Category: Hematology Authors: VJ Arun Anuradha Deorukhkar Aboobacker Mohamed Rafi Deepak Charles Rati Devendra Susheela J Innah Prabhakar Kedar Source Type: research

Effect of leukapheresis on pain reduction in leukemic priapism
Shahida Noushad, Dibyajyoti Sahoo, Abhishekh Basavarajegowda, Esha Toora, Purshotam PaudelAsian Journal of Transfusion Science 2022 16(1):124-127 Priapism is a rare presentation of Chronic Myeloid Leukaemia (CML). It is also considered a medical emergency as delay in treatment may lead to impotence. Prompt medical and surgical interventions such as hydroxyurea, analgesia, phenylephrine injection and aspiration, open surgical shunting, and local radiation therapy are essential. Leukapheresis effectively reduces leukocyte count rapidly and effectively, thereby an important therapy along with other standard of care in CML-in...
Source: Asian Journal of Transfusion Science - July 30, 2022 Category: Hematology Authors: Shahida Noushad Dibyajyoti Sahoo Abhishekh Basavarajegowda Esha Toora Purshotam Paudel Source Type: research

A case report on non-D HDFN: Highlighting the role of antibody screening in RhD positive antenatal women
Bharat Singh, Rajendra Chaudhary, Preeti Elhence, Jyoti Kala Bharati, Anubha SrivastavaAsian Journal of Transfusion Science 2022 16(1):121-123 The widespread use of anti-D immunoglobulin has resulted in a relative increase in the importance of non-D alloimmunization as a cause of hemolytic disease of the fetus and newborn (HDFN). Non-D alloantibodies that are capable of causing severe HDFN include anti-K, anti-E, and anti-c. Anti-c is clinically the most important Rh system antibody after anti-D. Here, we report three cases of neonates presenting with anemia and hyperbilirubinemia with strongly positive direct antiglobuli...
Source: Asian Journal of Transfusion Science - July 30, 2022 Category: Hematology Authors: Bharat Singh Rajendra Chaudhary Preeti Elhence Jyoti Kala Bharati Anubha Srivastava Source Type: research

Prevalence and specificity of red blood cell alloantibodies and autoantibodies in transfused Iranian & #946;-thalassemia patients: A systematic review and meta-analysis
CONCLUSION: The prevalence of red blood cell (RBC) alloantibodies in transfused Iranian β-thalassemia patients was high. Appropriate preventive strategies such as RBC phenotyping for patients before beginning transfusion and using extended RBC donor–recipient matching, specifically for Rh and Kell system, could be implemented to avoid complications in thalassemia patients. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - July 30, 2022 Category: Hematology Authors: Hosein Rostamian Ehsan Javandoost Mozhdeh Mohammadian Abbas Alipour Source Type: research

Therapeutic plasma exchange in HELLP syndrome: A life savior
CONCLUSION: Our data showed that TPE improved the treatment outcome in patients with HELLP syndrome despite being a Category III and IV indication among postpartum and antenatal females, respectively. However, a timely diagnosis and management are of paramount importance for a favorable outcome. TPE needs to be performed within 24 h of the diagnosis postdelivery when the patient is not responsive to the usual therapies, especially in class I HELLP syndrome. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - July 30, 2022 Category: Hematology Authors: Mohit Chowdhry Soma Agrawal Shiva Prasad Gajulapalli Uday Kumar Thakur Source Type: research

Transfusion-transmitted infections, its risk factors and impact on quality of life: An epidemiological study among & #946;-thalassemia major children
CONCLUSION: There was high burden of TTIs among multi-transfused β-TM children and it has significant negative impact on their quality of lives. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - July 30, 2022 Category: Hematology Authors: Bijit Biswas Narendra Nath Naskar Keya Basu Aparajita Dasgupta Rivu Basu Bobby Paul Source Type: research

A cross-sectional study on thrombopoietin levels in immune thrombocytopenia and its correlation with platelet count, megakaryocytes, and treatment response
CONCLUSION: Quantitative alterations in TPO are in a way regulated by qualitative efficacy of megakaryocytes rather than platelet or megakaryocyte count. Nonresponders with markedly increased TPO levels (due to qualitative megakaryocyte injury) are less likely to respond to TPO receptor agonist. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - July 30, 2022 Category: Hematology Authors: Gurleen Oberoi Mili Jain Shankar Madhav Natu Rashmi Kushwaha Anil Kumar Tripathi Ashutosh Kumar Source Type: research

Reappraisal of screening strategy in hepatitis B surface antigen-negative blood donors: Correlation with hepatitis B virus-DNA quantification
CONCLUSION: HBV-DNA should be implemented as a screening test of the blood donors to prevent TAHBV infection without potential donor rejection. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - July 30, 2022 Category: Hematology Authors: Md Sohrab Alam Tushar Samdani Md Sawkat Hassan Source Type: research

Type and screen method and Coombs crossmatch method for pretransfusion testing: A prospective comparative study in a tertiary care hospital in Delhi
CONCLUSION: T and S is a scientifically better method but needs to be implemented with caution. We need to develop our own cell panels having adequate representation of indigenous antigen (including In, Mi (a), etc.,). Large-scale studies need to be done in India with indigenous screening cells to evaluate efficacy and safety of T and S method. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - July 30, 2022 Category: Hematology Authors: K Devi Anu Sangeeta Pahuja Geetika Sharma Source Type: research

Comparison of efficacy of filter paper cyanmethemoglobin method with automated hematology analyzer for estimation of hemoglobin
CONCLUSION: FPCH is an efficient method, which is comparable to the automated hematology analyzers for Hb estimation. It could be used as an alternative screening tool for detection of Hb in a blood donation camp. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - July 30, 2022 Category: Hematology Authors: Lalit Kumar Ranjit Kangle Source Type: research

Prevalence of irregular red cell antibody in transfusion recipients vis-a-vis healthy blood donors attending a tertiary care hospital in North India
CONCLUSIONS: Since the risk of alloimmunization is more common in multitransfused patients, it is advisable to screen at least those cases for irregular antibodies. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - July 30, 2022 Category: Hematology Authors: Abhilasha Yadav Gaurav Raturi Bhardwaj Aparna Source Type: research

Assessment of dengue virus inactivation in random donor platelets using amotosalen and ultraviolet A illumination
CONCLUSIONS: Amotosalen/UVA pathogen inactivation treatment showed efficient inactivation of DENV in platelet components. Therefore, it seems to be a promising method for mitigating the risk of dengue transmission through transfusion of potentially contaminated platelet components in dengue-endemic countries such as India. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - July 30, 2022 Category: Hematology Authors: Ankit Kumar Aseem Kumar Tiwari Satendra Kumar Ashutosh Biswas Gurpreet Singh Kabita Chatterjee Sourit Chakroborty Sujatha Sunil Source Type: research

Assessing safety and efficacy of therapeutic plasma exchange in pediatric patients: A single-center experience
CONCLUSION: A total of 114 procedures were performed on these 24 patients. Fifteen patients with Category I indication showed good clinical outcome in terms of attainment of target ABO titre and/or decrease in the donor specific antibody. TPE is an effective therapeutic option in selected paediatric disorders. Our series of data on TPE procedures from paediatric perspective has shown safety and efficacy of the therapy. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - July 30, 2022 Category: Hematology Authors: Mohit Chowdhry PJ Mutjhukamaravel Soma Agrawal Shiva Prasad Gajulapali Uday Kumar Thakur Source Type: research