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Convalescent plasma: Would it prove to be magic potion/boon in the current scenario of COVID pandemic ?
Sangeeta PathakAsian Journal of Transfusion Science 2020 14(1):1-3 (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - July 23, 2020 Category: Hematology Authors: Sangeeta Pathak Source Type: research

Naturally occurring non-ABO alloantibodies in voluntary blood donors
Saurabh Lahare, Maitry D Gajjar, Nidhi Bhatnagar, Tarak Patel, Mamta Shah, Minal WasnikAsian Journal of Transfusion Science 2020 14(1):99-101 (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - July 23, 2020 Category: Hematology Authors: Saurabh Lahare Maitry D Gajjar Nidhi Bhatnagar Tarak Patel Mamta Shah Minal Wasnik Source Type: research

Validation of lateral flow assay for blood grouping on hemolyzed sample
Deepika Chenna, Shamee Shastry, Vijayram Reddy Kanukula, B Poornima BaligaAsian Journal of Transfusion Science 2020 14(1):98-98 (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - July 23, 2020 Category: Hematology Authors: Deepika Chenna Shamee Shastry Vijayram Reddy Kanukula B Poornima Baliga Source Type: research

Importance of documentation of the preanalytical variable on test requisition for sterility reporting of autoclave
Suchet Sachdev, Divjot Singh Lamba, Manisha Biswal, Ratti Ram Sharma, Neelam MarwahaAsian Journal of Transfusion Science 2020 14(1):96-97 (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - July 23, 2020 Category: Hematology Authors: Suchet Sachdev Divjot Singh Lamba Manisha Biswal Ratti Ram Sharma Neelam Marwaha Source Type: research

Bernard & #8211;Soulier syndrome (BSS) with uncontrollable menorrhagia
Debasmita Bhadra, Somajita ChakrabortyAsian Journal of Transfusion Science 2020 14(1):93-95Menorrhagia is a common problem in women of reproductive age group and 5% of women between 30 and 49 years of age group consult their general practitioner for this problem. Menorrhagia occurring in adolescent age group and perimenopausal age group is chiefly due to anovulatory cycles. In perimenopausal age group, local pathology like leiomyomas can also contribute to menorrhagia. Recently, bleeding disorders like von Willebrand Disease, single coagulation factor deficiencies particularly factor XI, VIII, Factor V and plate...
Source: Asian Journal of Transfusion Science - July 23, 2020 Category: Hematology Authors: Debasmita Bhadra Somajita Chakraborty Source Type: research

Posttransfusion purpura sans purpura: A novel presentation
Ravindra Prasad Thokala, Ashwin Anandan, Krishnamoorthy Radhakrishnan, Vinod Kumar Panicker, Niranj RathanAsian Journal of Transfusion Science 2020 14(1):90-92Posttransfusion purpura (PTP) is a rare condition that develops 5–10 days after transfusion of platelet containing blood component. Temporal relationship to blood transfusion, thrombocytopenia, and purpuric rashes with or without bleeding manifestation, supported by the serological presence of antiplatelet antibodies, are characteristic of PTP. We, herein, report a case of posttransfusion thrombocytopenia without purpuric rashes or bleeding symptoms, whi...
Source: Asian Journal of Transfusion Science - July 23, 2020 Category: Hematology Authors: Ravindra Prasad Thokala Ashwin Anandan Krishnamoorthy Radhakrishnan Vinod Kumar Panicker Niranj Rathan Source Type: research

Unexpected high platelet counts in a potential platelet donor: A clue to essential thrombocythemia
Anisha Navkudkar, Priti Desai, Sunil RajadhyakshaAsian Journal of Transfusion Science 2020 14(1):87-89Essential thrombocythemia (ET) (primary thrombocythemia) is a nonreactive, chronic myeloproliferative clonal disorder in which sustained megakaryocyte proliferation leads to an increase in the number of circulating platelets. It is silent disorder and is diagnosed as high platelet counts with or without associated symptoms or as an accidental finding. We, hereby, report a case of ET as an incidental finding during screening of a potential platelet donor. Donors with high platelet count should be investigated properly to ru...
Source: Asian Journal of Transfusion Science - July 23, 2020 Category: Hematology Authors: Anisha Navkudkar Priti Desai Sunil Rajadhyaksha Source Type: research

Hemolytic disease of the fetus and newborn due to multiple alloantibodies in pregnancy
We report the case of Hemolytic disease of fetus and newborn (HDFN) due to anti-E and anti-Fya antibody. Blood grouping was done using the conventional tube technique. Rh and Kell phenotyping of the patient and her husband performed by column agglutination and Duffy phenotyping were done by the conventional tube technique. Direct antiglobulin test was performed by column agglutination technique. Antibody screening and identification were done. Anti-E and Anti-Fya were identified with titer of Anti-E: 1:64 and Anti-Fya: 1:256. The patient's neonate developed jaundice. Phototherapy was given. Bilirubin stabilized ...
Source: Asian Journal of Transfusion Science - July 23, 2020 Category: Hematology Authors: Vidushi Gupta Meena Sidhu Saadat Nazir Shah Source Type: research

Implication of a positive virtual crossmatch with negative flow crossmatch: A mind-boggler
Mohit Chowdhry, Soma Agrawal, Yogita Thakur, Sandeep Guleria, Vandana SharmaAsian Journal of Transfusion Science 2020 14(1):79-82There are occasions when tests performed before considering a patient for transplant are ambiguous and require further workup. One such condition is the presence of a positive virtual crossmatch (VXm) (anti-human leukocyte antigen [HLA-A]*26: 01 antibody in this case) with a negative complement-dependent cytotoxicity, Luminex, and flow crossmatch. To ascertain the nature of the antibody, the beads used in single-antigen bead assay (SAB) were treated by acid to denature the antigens and...
Source: Asian Journal of Transfusion Science - July 23, 2020 Category: Hematology Authors: Mohit Chowdhry Soma Agrawal Yogita Thakur Sandeep Guleria Vandana Sharma Source Type: research

Patient blood management in a patient with multiple red cell antibodies (anti-C, anti-e, and anti-K) undergoing liver transplant in South India: A team approach
We report a case of a 64-year-old female from Bahrain, a known case of hepatitis C-related ESLD referred for LT surgery. She had a history of multiple uneventful transfusions in the preceding year. Her blood group was A-positive, direct antiglobulin test, and cold antibodies were negative. Indirect antiglobulin test was positive, and antibody identification confirmed the presence of anti-C, anti-e, and anti-K. Her red cell phenotype was R2R2and Kell negative (C-c+E+e-K-). The patient was started on erythropoietin. Requests for R2R2and Kell negative units were sent to various blood banks across the cou...
Source: Asian Journal of Transfusion Science - July 23, 2020 Category: Hematology Authors: Deepti Sachan Aseem K Tiwari Ravi Dara Dinesh Jothimani Ilankumaran Kaliamoorthy Srinivas Mettu Reddy Mohamed Rela Source Type: research

Red blood cell exchange in sickle cell disease patient with multiple alloantibodies
Geet Aggarwal, Aseem Kumar Tiwari, Pratibha Dhiman, Dinesh Arora, Swati Mehta Pabbi, Divya SetyaAsian Journal of Transfusion Science 2020 14(1):70-73There are several reports in medical literature about Red Cell Exchange (RCE) being routinely performed pre-operatively in sickle cell disease patients to provide immediate decrease in HbS concentration and prevent post-operative complications. We would like to present one such case of SCD who also had multiple allo-antibodies and had to undergo hemi-arthroplasty for avascular necrosis of head femur. Grouping and antibody screening was performed using column agglutination tech...
Source: Asian Journal of Transfusion Science - July 23, 2020 Category: Hematology Authors: Geet Aggarwal Aseem Kumar Tiwari Pratibha Dhiman Dinesh Arora Swati Mehta Pabbi Divya Setya Source Type: research

Immuno-hematological consequence of intravenous drug abuse ?
We present here a case of a 28-year-old man who presented with a rather unique predicament of having developed four different alloantibodies after exposure to allogenic blood through IV drug abuse. This case was detected promptly due to routine usage of type and screen policy for all the patients receiving transfusion. Such screening for atypical antibodies must be instituted to preemptively identify these antibodies and arrange compatible blood, which could have been difficult otherwise, at short notice during routine crossmatch. This is the first of its kind case ever reported from India and has no precedence. (Source: A...
Source: Asian Journal of Transfusion Science - July 23, 2020 Category: Hematology Authors: Aikaj Jindal Anil Luther Aseem K Tiwari Amit Mahajan Subhasis Mitra Source Type: research

Passenger lymphocyte syndrome in a bidirectional ABO-mismatched renal transplant
PA Prethika, Shamee Shastry, Ganesh Mohan, Ravindra Attur Prabhu, Shankar Prasad Nagaraju, Dharshan RangaswamyAsian Journal of Transfusion Science 2020 14(1):63-66Passenger lymphocyte syndrome (PLS), a subtype of graft-versus-host disease, is due to the production of antibodies by the donor “passenger” B lymphocytes against recipient's red cells. It is a rare disorder encountered mostly in ABO blood group-mismatched solid organ transplantation. The present case report illustrates the clinical presentation and the mode of management of PLS in a bidirectional ABO-incompatible renal transp...
Source: Asian Journal of Transfusion Science - July 23, 2020 Category: Hematology Authors: PA Prethika Shamee Shastry Ganesh Mohan Ravindra Attur Prabhu Shankar Prasad Nagaraju Dharshan Rangaswamy Source Type: research

A rare case of naturally occurring allo anti-Jk(a) missed in manual screening test on tube method
Conclusion: An unusual naturally occurring anti-Jk(a) detected by solid-phase red-cell adherence but not reacting by tube technique reflected on the sensitivity of the methods used. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - July 23, 2020 Category: Hematology Authors: Ashish N Kanani Snehal B Senjaliya Manisha M Rajapara Anurag K Gupta Sanmukh R Joshi Source Type: research

Applying Donath & #8211;Landsteiner test for the diagnosis of paroxysmal cold hemoglobinuria
Aseem Kumar Tiwari, Geet Aggarwal, Subhasis Mitra, Dinesh Arora, Gunjan Bhardwaj, Ankita Ratan, Divya SetyaAsian Journal of Transfusion Science 2020 14(1):57-5961-year old male patient was admitted to the hospital with clinical picture of hemolytic anemia with hemoglobinuria. Patient was suspected to have Infectious Mononucleosis (IM) with Auto Immune Hemolytic Anemia (AIHA). DAT was positive with anti-C3d specificity. Donath Landsteiner (DL) test was positive; confirming Paroxysmal Cold Hemoglobinuria (PCH). The final diagnosis was IM with PCH. Patient was managed conservatively and discharged after seven days. DL test sp...
Source: Asian Journal of Transfusion Science - July 23, 2020 Category: Hematology Authors: Aseem Kumar Tiwari Geet Aggarwal Subhasis Mitra Dinesh Arora Gunjan Bhardwaj Ankita Ratan Divya Setya Source Type: research