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Masquerading of mismatched blood transfusion by underlying autoimmune hemolytic anemia
Priyanka Samal, Sarita Pradhan, Sudipta Sekhar DasAsian Journal of Transfusion Science 2019 13(2):142-144 Mismatched blood transfusion due to immunohematological discrepancy is relatively uncommon and in most instances occurs due to Type IV blood group discrepancy which is the discrepancies between forward and reverse groupings. Here, we present a case of a 15-year-old girl with preexisting autoimmune hemolytic anemia (AIHA) who inadvertently received 3 units of wrongly matched packed red blood cell (PRBC), followed by severe intravascular hemolysis. On detailed immunohematological investigation, the patient was found to ...
Source: Asian Journal of Transfusion Science - December 2, 2019 Category: Hematology Authors: Priyanka Samal Sarita Pradhan Sudipta Sekhar Das Source Type: research

An unusual report of anti-N antibody presenting as ABO discrepancy in an old female patient in Palestine
Fekri H Samarah, Mahmoud A SrourAsian Journal of Transfusion Science 2019 13(2):140-141 The MNS is a highly complex immune blood group system which is almost equal to Rh in size and complexity. Anti-N antibody is naturally occurring in general, cold reactive IgM or IgG saline agglutinin and relatively rare when compared with anti-M. The immune type anti-N is seldom encountered. Anti-N antibody is not clinically significant unless it reacts at 37°C. Clinically significant anti-N antibody is reactive at 37°C or in the anti-human globulin phase, which may cause delayed hemolytic transfusion reactions ...
Source: Asian Journal of Transfusion Science - December 2, 2019 Category: Hematology Authors: Fekri H Samarah Mahmoud A Srour Source Type: research

Role of de novo DQ donor-specific antibody in antibody-mediated rejection in renal transplant recipient: A case study
This study suggests the role of DQ antibodies in determining the graft survival and to highlight the need of HLA DQ typing as a routine of the diagnostic work-up in a solid organ transplant. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - December 2, 2019 Category: Hematology Authors: Mohit Chowdhry Manthan Patel Yogita Thakur Vandana Sharma Source Type: research

Deciphering a delayed hemolytic transfusion reactions nightmare & #8211; Case of Chido/Roger antibodies
Soumya Das, PS Priyamvada, Abhishekh Basavarajegowda, Ankit MathurAsian Journal of Transfusion Science 2019 13(2):132-135 Antibodies against Rh (CEce) and Kidd (Jka and Jkb) system antigens are mostly implicated in delayed hemolytic transfusion reactions (DHTR), which is a potentially life-threatening complication observed in patients receiving chronic transfusions. Here, we are describing a case of Chido/Roger antibody which presented to our laboratory as DHTR. The clinical presentation and laboratory findings including the immunohematological workups with regard to the reaction are discussed, with a special emphasis on ...
Source: Asian Journal of Transfusion Science - December 2, 2019 Category: Hematology Authors: Soumya Das PS Priyamvada Abhishekh Basavarajegowda Ankit Mathur Source Type: research

Detection of a rare subgroup of A phenotype while resolving ABO discrepancy
We report a case of a 54-year-old patient whose red cells showed a discrepancy between cell and serum grouping on initial testing. Serological investigation included absorption elution tests and saliva testing after performing initial blood grouping. Molecular genotyping of the ABO gene was performed by DNA sequencing of exons 6 and 7 of the ABO gene. The serological characteristics of the patient's red cells were similar to Ax subtype. The patient was a secretor and only H substance was present in the saliva. Serum did not show the presence of anti-A1. Molecular genotyping confirmed the ABO status as Aw06/O13. ...
Source: Asian Journal of Transfusion Science - December 2, 2019 Category: Hematology Authors: Revathy Nair Harita Gogri Swati Kulkarni Debasish Gupta Source Type: research

Effectiveness of bone marrow-derived mononuclear stem cells for neurological recovery in participants with spinal cord injury: A randomized controlled trial
CONCLUSIONS: Significant motor neurological recovery and AIS-grade promotion was observed in Group-1 as compared to Group-2 and 3. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - December 2, 2019 Category: Hematology Authors: Rajeshwar Nath Srivastava Ashok Kumar Agrahari Alka Singh Tulika Chandra Saloni Raj Source Type: research

Comparison of a column agglutination technology-based automated immunohematology analyzer and a semiautomated system in pretransfusion testing
CONCLUSION: Based on study results, Vision was approved for routine use in laboratory. It was found to be reliable with considerably shorter TAT and capable of handling high throughput of immunohematological tests. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - December 2, 2019 Category: Hematology Authors: Ravi C Dara Aseem Kumar Tiwari Subhasis Mitra Deviprasad Acharya Geet Aggarwal Dinesh Arora Gunjan Bhardwaj Source Type: research

Evaluation of molecular typing and serological methods in solving discrepant results of weak and partial D (Rh) in South Egypt
CONCLUSION: Our study identified D variants (weak D and partial D categories) of the antigen D and determined the frequency and composition of partial D and weak D alleles in our population. Molecular typing also confirmed most of the results obtained from serological methods. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - December 2, 2019 Category: Hematology Authors: Rania M Bakry Eman Nasreldin Ashraf E Hassaballa Samar M Mansour Sahar A Aboalia Source Type: research

Mutational analysis of thalassemia in transfusion-dependent beta-thalassemia patients from central India
CONCLUSION: The identification of the genotypes helps to define the severity of the phenotype, plan therapy and form the basis of the comprehensive diagnostic database that would be useful not only for genetic counseling but prenatal diagnosis as well, contributing to the current focus of the National Policy to prevent and control hemoglobinopathies. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - December 2, 2019 Category: Hematology Authors: Manisha Shrivastava Rashmi Bathri Nirupama Chatterjee Source Type: research

Reversal of warfarin-coagulopathy: How to improve plasma transfusion practice in a community hospital setting ?
CONCLUSION: We conclude that plasma transfusion practices may be improved by a combination of education and active enforcement of warfarin reversal guidelines. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - December 2, 2019 Category: Hematology Authors: Lubna Bashir Munshi Braghadheeswar Thyagarajan Aasems Jacob Shil Patel Steve Zheng Liu Arpad Szallasi Source Type: research

Comparison of UV spectrometry and fluorometry-based methods for quantification of cell-free DNA in red cell components
CONCLUSION: Due to high interassay variability between the two methods and the better precision and accuracy of Qubit, it is recommended that fluorometry-based method be used for the quantification of cfDNA in blood components. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - December 2, 2019 Category: Hematology Authors: Dheeraj Khetan Nitesh Gupta Rajendra Chaudhary Jai Shankar Shukla Source Type: research

Role of plasma exchange in postpartum microangiopathies: An experience from a tertiary care center
CONCLUSION: Early initiation of PE therapy in postpartum thrombotic microangiopathies can reduce morbidity and mortality associated with them. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - December 2, 2019 Category: Hematology Authors: Rekha Hans Satya Prakash Divjot Singh Lamba Ratti Ram Sharma Pankaj Malhotra Vanita Suri Neelam Marwaha Source Type: research

Umbilical cord blood quality and quantity: Collection up to transplantation
Seyed Hadi Mousavi, Morteza Zarrabi, Saeid Abroun, Mona Ahmadipanah, Bahareh AbbaspanahAsian Journal of Transfusion Science 2019 13(2):79-89 Umbilical cord blood (UCB) is an attractive source of hematopoietic stem cells for transplantation in some blood disorders. One of the major factors that influence on transplantation fate is cord blood (CB) cell count, in addition to human leukocyte antigen similarity and CD34+ cell number. Here, we review the factors that could effect on quality and quantity of CBUs. Relevant English-language literatures were searched and retrieved from PubMed using the terms: CB, quality...
Source: Asian Journal of Transfusion Science - December 2, 2019 Category: Hematology Authors: Seyed Hadi Mousavi Morteza Zarrabi Saeid Abroun Mona Ahmadipanah Bahareh Abbaspanah Source Type: research

Hemolytic events during therapeutic plasma exchange: Root cause analysis
Sachan Deepti, Saha Suryatapa, Kaliamoorthy Ilankumaran, Rela MohamedAsian Journal of Transfusion Science 2019 13(1):76-78 (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Sachan Deepti Saha Suryatapa Kaliamoorthy Ilankumaran Rela Mohamed Source Type: research

Successful therapeutic plasma exchange in a patient with Morvan syndrome
Rounak Dubey, Rajeev S Mallhi, Bhushan Asthana, Neerja Kushwaha, Arvind YadavAsian Journal of Transfusion Science 2019 13(1):73-75Morvan syndrome is a rare autoimmune disorder, characterized by hyperexcitability of both central and peripheral nervous systems, accompanied by autonomic dysfunction and hallucinations.[1] Therapeutic plasma exchange (TPE) has been found to be an effective mode of treatment for this disease, but there is limited literature supporting the same.[2] A 26-year-old male was admitted to our hospital and diagnosed with a case of Morvan syndrome, based on the clinical picture and laboratory findings. W...
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Rounak Dubey Rajeev S Mallhi Bhushan Asthana Neerja Kushwaha Arvind Yadav Source Type: research