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Efficacy of cascade plasmapheresis in comparison with conventional therapeutic plasma exchange for relapsed atypical hemolytic uremic syndrome: A case report
This report presents the utilization of cascade plasmapheresis and its advantages over TPE in a patient with relapsed aHUS. There was a 73% decrement in antifactor H antibody levels following cascade plasmapheresis. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 12, 2022 Category: Hematology Authors: Ashwinkumar Vaidya Isha Polavarapu Ravindra Attur Prabhu Ganesh Mohan Shamee Shastry PA Prethika Source Type: research

Direct antibody test negative autoimmune hemolytic anemia with pulmonary tuberculosis: A diagnostic challenge
We report a case of a 14-year-old boy who presented with hemolytic anemia and pneumonia. The Coombs test was repeatedly negative. After ruling out the possible infectious and noninfectious causes by extensive investigations, he was diagnosed as DAT-negative AIHA by monospecific antibody test with 4°C low ionic strength saline washes and column agglutination method which revealed the presence of IgG-2+ antibodies. Bronchoalveolar lavage fluid for acid-fast bacilli and gene Xpert was also positive. It is important to recognize TB as a cause of AIHA in South Asian countries where its incidence is high. ...
Source: Asian Journal of Transfusion Science - November 12, 2022 Category: Hematology Authors: Agarwal Sheetal Singh Ruby P Singh Dhirendra Gupta Anubhav Nandan Devki Source Type: research

A case of naturally occurring anti-Dia antibody in a young man
We reported a case of naturally occurring of anti-Dia in a young man who presented to our hospital for wound debridement of fingers injury. His serological results were suggestive of anti-Dia antibody, and his molecular blood group showed he has Di (a-b+) antigen. Anti-Dia may be clinically significant. It can cause mild-to-severe HDFN, but there are only infrequent reports of it being clearly implicated in a hemolytic transfusion reaction. We suggest the need for reagent red blood cell panels to include Dia antigen-positive cells in antibody identification tests for our populations. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 12, 2022 Category: Hematology Authors: Salfarina Iberahim Noor Haslina Mohd Noor Mohd Nazri Hassan Rosnah Bahar Shafini Mohdmed Yusoff Marini Ramli Wan Suriana Wan Abdul Rahman Zefarina Zulkafli Marne Abdullah Ho Sook Fong Tengku Muzaffar Tengku Mohamed Shihabudin Hisham Atan Edinur Norul Haja Source Type: research

ABO-incompatible granulocyte transfusion: Is ABO subgroup a barrier ?
We report a case of ABO-incompatible prophylactic GTx, in a case of acute myeloblastic leukemia. Postcollection processing of the granulocyte product was done to reduce the red blood cell volume to <5 ml, making it safe for transfusion. The transfusion was successful in stabilizing the total leukocyte counts in the patient. The patient was monitored, and there were no adverse reactions posttransfusion. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 12, 2022 Category: Hematology Authors: Soma Agrawal Mohit Chowdhry Uday Kumar Thakur Source Type: research

Management of Bombay Rh negative with clinically significant anti-S for CABG surgery
S Anuragaa, Dibyajyoti Sahoo, Pragya Silwal, Abhishekh Basavarajegowda, Esha TooraAsian Journal of Transfusion Science 2022 16(2):269-272The Bombay Rh D negative is the rarest of the rare in blood groups. A 65-year-old male patient with coronary artery disease was admitted for CABG. During grouping, forward showed no agglutination in A, B, D, and H, and reverse showed agglutination in A, B, and O cell. The blood group was confirmed as Bombay Rh D negative. Four units of PRBC was requested for the surgery as it was cardiothoracic surgery. We checked our inventory and rare donor list for Bombay-negative blood. Acute normovol...
Source: Asian Journal of Transfusion Science - November 12, 2022 Category: Hematology Authors: S Anuragaa Dibyajyoti Sahoo Pragya Silwal Abhishekh Basavarajegowda Esha Toora Source Type: research

Sickle cells are not necessarily protective against falciparum- A case report
We report an unusual case of a child with homozygous SCD presenting with falciparum malaria and had hyper parasitemia and severe anemia which completely resolved following treatment. Clinical suspicion in our case arose considering the endemic nature of malaria in our country. The two overlapping injuries to spleen reduced the clearance of parasites by the spleen as evidenced by high parasite load. Our case report reinforces malaria as a cause of clinical worsening of SCD and highlights the importance of a multifactorial approach in the management of worsening anemia in SCD. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 12, 2022 Category: Hematology Authors: Jess Elizabeth Rasalam Snehil Kumar K Sujith NA Fouzia Arpana Palle Dolly Daniel Sukesh Chandran Nair Source Type: research

Report of plasma exchange in a rare case of association of myasthenia gravis with thymoma and parathyroid adenoma
Nippun Prinja, Garima Siwach, Sarath Aleti, Rekha Hans, Aastha Takkar, Sahil Mehta, Ratti R Sharma, Vivek LalAsian Journal of Transfusion Science 2022 16(2):263-265 Myasthenia with thymoma and parathyroid adenoma is a rare presentation. Very few cases have been reported of this association without much role of plasma exchange in these patients. Here, we present our experience of plasma exchange in this rare clinical entity. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 12, 2022 Category: Hematology Authors: Nippun Prinja Garima Siwach Sarath Aleti Rekha Hans Aastha Takkar Sahil Mehta Ratti R Sharma Vivek Lal Source Type: research

Panagglutination on the indirect antiglobulin test... this is the challenge!
Styliani I Kokoris, Dimitrios Kalantzis, Dimitra Moschandreou, Konstantina Papaioannou, Elisavet GrouziAsian Journal of Transfusion Science 2022 16(2):257-262 Panagglutination on the indirect antiglobulin test is one of the most challenging dilemmas of pretransfusion testing. It occurs when patient sera react with all red blood cells tested, that is, with both screening and identification panel cells. Two main questions must be answered. The first is to determine whether panagglutination results from the presence of autoantibody and/or alloantibody (single alloantibody or multiple alloantibodies or antibody to high-incide...
Source: Asian Journal of Transfusion Science - November 12, 2022 Category: Hematology Authors: Styliani I Kokoris Dimitrios Kalantzis Dimitra Moschandreou Konstantina Papaioannou Elisavet Grouzi Source Type: research

A study to assess the relationship between donor uric acid levels and supernatant hemolysis in stored packed red blood cell units
CONCLUSION: Higher levels of serum UA of blood donors seem to have a protective effect on the stored PRBC units as shown in this study. Hence, the potential of UA as one of the constituents of RBC additive solutions might lead to the enhancement of the quality of stored PRBC units by decreasing the RBC storage lesions. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 12, 2022 Category: Hematology Authors: Himanshu Kumar Singh Amit Kumar Biswas Joseph Philip Neerja Kushwaha Bhasker Mukherjee Ajay K Baranwal Source Type: research

Reference interval of platelet counts and other platelet indices in apparently healthy blood donors in North India according to Clinical and Laboratory Standards Institute guidelines: Need to redefine the platelet count cutoffs for repeat plateletpheresis donation ?
CONCLUSION: Based on our results, we are of the opinion that the PLT count cutoffs for repeat plateletpheresis donation may need to be revised downwards for our country which would also mitigate the scarcity of apheresis donors. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 12, 2022 Category: Hematology Authors: Swati Pabbi Aseem Kumar Tiwari Geet Aggarwal Govind Sharma Arghyadeep Marik Aanchal Sunil Luthra Anand Prakash Upadhyay Manish Kumar Singh Source Type: research

Platelet additive solution suspended apheresis platelets in a tertiary care hospital: A step toward universal single donor platelets
CONCLUSION: PAS added SDP is an efficient strategy to reduce the ABO-antibody levels significantly. PAS added SDP also helps in the better inventory management of available groups. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 12, 2022 Category: Hematology Authors: Mohit Chowdhry Soma Agrawal Bindu Prakash Uday Kumar Thakur Manoj Mishra Source Type: research

Internal quality control for HIV testing of blood donors - Dried tube specimen as a cost-effective alternative
CONCLUSION: Plasma in form of DTS maintained stability when stored at 2–8°C for 1 year. This provides evidence that DTS can be a modality for the production of cost-effective, stable, in-house control material for resource-restricted countries. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 12, 2022 Category: Hematology Authors: Ashish Dhoot Joy J Mammen Nitty S Mathews Rajesh Kannangai Dolly Daniel S Prasannakumar Source Type: research

Ramadan favors first blood donation, but not frequent donation: Results of 10,145 blood donors from Algeria
CONCLUSIONS: Reducing the gender gap and promoting return could significantly improve the volume of blood donations in Algeria. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 12, 2022 Category: Hematology Authors: Mounir Ould Setti Djamal-Eddine Damerdji Abdelkader Nebab Ari Voutilainen Source Type: research

Major and minor subgroup profile of blood in patients receiving multiple transfusions and donors
CONCLUSION: IAT negativity in all patient groups suggests that we do not develop alloimmunization, but the high rates of double population suggest a high risk of alloimmunization. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 12, 2022 Category: Hematology Authors: Mehmet Fatih Orhan Merve Pilavci Adig & #252;l Mustafa Altindi & #351; Mehmet K & #246;ro & #287;lu Source Type: research

Plateletpheresis donor deferral pattern: A retrospective 4-year data analysis at tertiary care center in India
CONCLUSION: There is potential for increasing the number of eligible plateletpheresis donors if the present donor selection criteria were relaxed to a minimum Hb of 12 g/dl and minimum platelet count of 140 × 103/μl. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 12, 2022 Category: Hematology Authors: Brijesh Kumar Yadav Harsha Shrivastava Rahul Katharia Rajendra K Chaudhary Source Type: research