Coomb & #39;s negative cold agglutinin disease: A rare report of an incidentally detected case
K V Vinu Balraam, Adnan Masood, Nidhi Garg, Venkatesan SomasundaramAsian Journal of Transfusion Science 2021 15(2):233-236 Cold agglutinin disease (CAD) is a rare type of autoimmune hemolytic anemia which usually results due to production of immunoglobulin M-type autoantibody against the I/i and H antigens on red blood cell membrane. They can be idiopathic or may be due to underlying lymphoproliferative disorders or atypical infections. It can have a varied presentation ranging from being incidentally detected to being totally transfusion dependent for a longer or shorter duration. Several factors play a role in determini...
Source: Asian Journal of Transfusion Science - November 1, 2021 Category: Hematology Authors: K V Vinu Balraam Adnan Masood Nidhi Garg Venkatesan Somasundaram Source Type: research

Case report and strategies to mitigate passive hemolysis with platelet transfusions in children
We report here a case of a nine year old boy who received three units of mismatched platelet concentrates(PC) followed by acute hemolysis. On further investigation, one of the donors of the PC, who was typed as O positive, found to have high anti-A and anti-B titres of 1:128. This highlights the importance of matched platelet transfusions or modifying the product in pediatric setting, who are susceptible for passive hemolysis. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 1, 2021 Category: Hematology Authors: Merline Augustine Mohandoss Murugesan Kaduveettil Gopinathan Gopakumar TK Jithin Source Type: research

Patient blood management in a neurosurgical patient with anti-e antibody
Sreethu Chand, Anila Mani, R Amita, Debasish GuptaAsian Journal of Transfusion Science 2021 15(2):226-228 The successful application of patient blood management approach in a 48-year-old neurosurgery patient planned for meningioma excision and requiring transfusion is described. The patient had multiple past immunizing events and developed antibody against a high-frequency antigen “e” of the Rh blood group system. With the joint effort from transfusion medicine specialist, anesthesiologist, and surgeon, the patient was successfully managed using the preoperative autologous blood donation program....
Source: Asian Journal of Transfusion Science - November 1, 2021 Category: Hematology Authors: Sreethu Chand Anila Mani R Amita Debasish Gupta Source Type: research

Positive/external control of rapid diagnostic tests: A step forward in malaria screening
Rasika D Setia, Mitu Dogra, Anil Handoo, Prerna SachdevaAsian Journal of Transfusion Science 2021 15(2):261-262 (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 1, 2021 Category: Hematology Authors: Rasika D Setia Mitu Dogra Anil Handoo Prerna Sachdeva Source Type: research

Clinical relevance of hepatitis B core total antibody in the detection of occult hepatitis B infection in patients with liver disease and blood donors
Vijeta Bajpai, Ekta Gupta, Aashish Chaudhary, Meenu BajpaiAsian Journal of Transfusion Science 2021 15(2):259-260 (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 1, 2021 Category: Hematology Authors: Vijeta Bajpai Ekta Gupta Aashish Chaudhary Meenu Bajpai Source Type: research

A rare case of mistaken identity - Historical blood group saved the situation
Anand Deshpande, R BasavannaAsian Journal of Transfusion Science 2021 15(2):256-258 (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 1, 2021 Category: Hematology Authors: Anand Deshpande R Basavanna Source Type: research

A successful booster umbilical cord blood transplantation for a 10-year-old patient with beta-thalassemia major in India
We present a case of a 10-year-old girl with beta-thalassemia major who was successfully cured with allogeneic booster umbilical cord blood (UCB) transplantation with outcome data after 3 years of transplantation, in India. Postdiagnosis, she was on regular once-a-month blood transfusion until the age of 10 years, with no improvement. No serious adverse events occurred in the patient post-UCB transplantation. Chronic graft versus host disease was limited and was managed by medicines. Signs of primary graft rejection were also not seen. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 1, 2021 Category: Hematology Authors: Vijay Ramanan Source Type: research

Blood group discrepancy in mixed-type autoimmune hemolytic anemia in a pediatric patient
We report a rare case of mixed AIHA in a 15 years female showing severe anemia, blood group discrepancy, and cross-match incompatibility. She received transfusion of least incompatible packed RBCs without any untoward effect. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 1, 2021 Category: Hematology Authors: Minal Wasnik Saurabh Lahare Tushar Jagzape Ramesh Kumar Chandrakar Source Type: research

A case series of hemorrhagic neurological complications of sickle cell disease: Multiple faces of an underestimated problem!
We report three uncommon spontaneous hemorrhagic manifestations of sickle cell anemia – one case of parenchymal (intracerebral) bleed who presented with acute onset of parkinsonism and two cases of extradural hematoma (EDH) of which one patient had recurrent EDH at the same site which is hitherto not reported in the literature. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 1, 2021 Category: Hematology Authors: Sangita D Kamath Manish Ganesh Pai Source Type: research

Surgical management of endometriosis in a severe Hemophilia A female patient and the role of transfusion medicine specialist: A case report with review of literature
We present a rare case of female hemophilia due to skewed X-inactivation which adversely affected the quality of patient life. She presented with recurrent abdominal pain and was diagnosed with severe endometriosis and underwent total abdominal hysterectomy with left salpingo-oophorectomy and appendicectomy. She was infused recombinant factor VIII both prophylactically and postoperatively as per the World Federation of Hemophilia guidelines. Recombinant Factor VIII was supplemented every 12th hourly and Factor VIII activity levels were monitored daily. She was discharged uneventfully on the postoperative day 21 after scree...
Source: Asian Journal of Transfusion Science - November 1, 2021 Category: Hematology Authors: Sanooja Pinki Ganesh Mohan Divya Venugopal Susheela J Innah Source Type: research

Coomb & #39;s negative cold agglutinin disease: A rare report of an incidentally detected case
K V Vinu Balraam, Adnan Masood, Nidhi Garg, Venkatesan SomasundaramAsian Journal of Transfusion Science 2021 15(2):236-239 Cold agglutinin disease (CAD) is a rare type of autoimmune hemolytic anemia which usually results due to production of immunoglobulin M-type autoantibody against the I/i and H antigens on red blood cell membrane. They can be idiopathic or may be due to underlying lymphoproliferative disorders or atypical infections. It can have a varied presentation ranging from being incidentally detected to being totally transfusion dependent for a longer or shorter duration. Several factors play a role in determini...
Source: Asian Journal of Transfusion Science - November 1, 2021 Category: Hematology Authors: K V Vinu Balraam Adnan Masood Nidhi Garg Venkatesan Somasundaram Source Type: research

Case report and strategies to mitigate passive hemolysis with platelet transfusions in children
We report here a case of a nine year old boy who received three units of mismatched platelet concentrates(PC) followed by acute hemolysis. On further investigation, one of the donors of the PC, who was typed as O positive, found to have high anti-A and anti-B titres of 1:128. This highlights the importance of matched platelet transfusions or modifying the product in pediatric setting, who are susceptible for passive hemolysis. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - November 1, 2021 Category: Hematology Authors: Merline Augustine Mohandoss Murugesan Kaduveettil Gopinathan Gopakumar TK Jithin Source Type: research

Patient blood management in a neurosurgical patient with anti-e antibody
Sreethu Chand, Anila Mani, R Amita, Debasish GuptaAsian Journal of Transfusion Science 2021 15(2):229-231 The successful application of patient blood management approach in a 48-year-old neurosurgery patient planned for meningioma excision and requiring transfusion is described. The patient had multiple past immunizing events and developed antibody against a high-frequency antigen “e” of the Rh blood group system. With the joint effort from transfusion medicine specialist, anesthesiologist, and surgeon, the patient was successfully managed using the preoperative autologous blood donation program....
Source: Asian Journal of Transfusion Science - November 1, 2021 Category: Hematology Authors: Sreethu Chand Anila Mani R Amita Debasish Gupta Source Type: research

A rare acute pain transfusion reaction: A case report and review of literature
Remi Remakanth, Priyatesh C Dwivedi, Abhishekh B GowdaAsian Journal of Transfusion Science 2021 15(2):226-228 A 40-year-old male patient presented to the emergency department of our hospital with complaints of anasarca, mild dyspnea, orthopnea, on and off vomiting, and decreased urine output. A provisional diagnosis of chronic kidney disease was made and was planned for hemodialysis. In view of severe anemia,1 packed red blood cell (PRBC) was requested for the same and after pretransfusion testing, one unit of buffy-coat poor, nonleukofiltered, coombs cross-match compatible, fresh (<7 days old) saline-adenine-g...
Source: Asian Journal of Transfusion Science - November 1, 2021 Category: Hematology Authors: Remi Remakanth Priyatesh C Dwivedi Abhishekh B Gowda Source Type: research

Anti-Emm, a rare specificity to the high-incidence antigen Emm in an Indian patient defining the new blood group system EMM (ISBT042)
Ripal J Shah, Snehal B Senjaliya, V Harimoorthy, Anna Burgos, Sunitha Vege, Christine Lomas-Francis, Connie M Westhoff, Sanmukh Ratilal JoshiAsian Journal of Transfusion Science 2021 15(2):223-225 A transfusion recipient lacking a high-incidence antigen (HIA) and has corresponding alloantibody pose a problem in providing compatible blood unit. We encountered a patient with an antibody to an HIA that required identification to assess if compatible blood could be organized. A 65-year-old male was posted for coronary artery bypass grafting surgery. His blood specimen collected in EDTA was referred to the blood bank to provid...
Source: Asian Journal of Transfusion Science - November 1, 2021 Category: Hematology Authors: Ripal J Shah Snehal B Senjaliya V Harimoorthy Anna Burgos Sunitha Vege Christine Lomas-Francis Connie M Westhoff Sanmukh Ratilal Joshi Source Type: research