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Critical evaluation of donor direct antiglobulin test positivity: Implications in cross-matching and lessons learnt
We report two cases of DAT positive donors with no clinical or laboratory evidence of hemolysis. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Vandana Puri Aruna Chhikara Geetika Sharma Shivali Sehgal Sunita Sharma Source Type: research

Successful treatment of Sezary syndrome with extracorporeal photopheresis & #8211; The first attempt in India
Aseem K Tiwari, Dinesh Arora, Pratibha Dhiman, Sheilly Kapoor, Geet Aggarwal, Ravi C Dara, Ashok VaidAsian Journal of Transfusion Science 2019 13(1):66-69Sezary syndrome (SS) is more aggressive leukemic variant of cutaneous T-cell lymphoma in which a significant number of circulating malignant (Sezary) cells are observed in peripheral blood. Although single-agent or combination chemotherapy regimens have produced moderately high response rates in patients with advanced-stage SS, these responses are invariably not durable. Extracorporeal photopheresis (ECP) is recommended as an immunomodulator treatment, offering better lif...
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Aseem K Tiwari Dinesh Arora Pratibha Dhiman Sheilly Kapoor Geet Aggarwal Ravi C Dara Ashok Vaid Source Type: research

Intraoperative acute hematuria: Sole clue to mismatch transfusion
Priya Rudingwa, Muthapillai Senthilnathan, Srinivasan Suganya, Sakthirajan PanneerselvamAsian Journal of Transfusion Science 2019 13(1):63-65Hemolytic transfusion reactions (HTRs) remain one of the dreaded complications of transfusion-related morbidity and mortality. Here, we describe the diagnosis and management of acute HTR following transfusion of ABO-incompatible packed red blood cell under general anesthesia which manifested solely as acute intraoperative hematuria. A 65-year-old, diabetic male was scheduled for emergency re-explorative laparotomy in view of suspected anastomotic leak following subtotal gastrectomy. O...
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Priya Rudingwa Muthapillai Senthilnathan Srinivasan Suganya Sakthirajan Panneerselvam Source Type: research

A case of severe donor reaction leading to grievous injury
Vinu Rajendran, Revathy Nair, George Paul Thaliath, Debasish GuptaAsian Journal of Transfusion Science 2019 13(1):60-62Adverse events of variable severity may occur occasionally following whole blood donation. We are reporting a case of severe donor reaction leading to grievous injury. A first-time male voluntary blood donor donated blood in our blood donation camp. The donation was uneventful, and he left the premise after 20 min of postdonation observation and advice. Several minutes later, he fell on the road and injured himself complicated with severe delayed vaso-vagal reaction. The donor had lacerated wound over the ...
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Vinu Rajendran Revathy Nair George Paul Thaliath Debasish Gupta Source Type: research

Incompatible crossmatch: First sign of a hemolytic transfusion reaction due to out-of-group platelet transfusion
Debapriya Basu, Sabita Basu, Joydeep Roy, Mahua Reddy, Mammen Chandy, Jaydeep BhaumikAsian Journal of Transfusion Science 2019 13(1):57-59Platelet (PLT) transfusion is undertaken in a variety of clinical settings with thrombocytopenia, with or without bleeding. Since PLTs are most often stored in donor plasma, group-specific PLT transfusions are preferred to out-of-group transfusions. PLTs adsorb ABO antigens over their surface from the plasma. In major ABO-incompatible PLT transfusions, anti-A/B from the patient plasma react with the ABO antigens on transfused PLTs and can potentially cause adverse reactions or PLT refrac...
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Debapriya Basu Sabita Basu Joydeep Roy Mahua Reddy Mammen Chandy Jaydeep Bhaumik Source Type: research

A case of rare anti-Hro alloantibody in a tertiary care center in India
Mohit Chowdhry, Soma Agrawal, Uday Kumar ThakurAsian Journal of Transfusion Science 2019 13(1):54-56Anti-Hro is an alloantibody produced in individuals with -D- phenotype after a sensitizing event. Owing to the rarity of this antigen negative unit, registration in rare donor registries helps in procuring blood components at the earliest. We had a patient of -D- with anti-Hro antibody who required 7 units of red cells which was unavailable at our center. The patients near relatives were typed in search of a similar phenotype blood. Search was made for the rare units and Japanese Red Cross Society, American Red Cross Society...
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Mohit Chowdhry Soma Agrawal Uday Kumar Thakur Source Type: research

Effect of autologous PRP on wound healing in dental regenerative surgeries and its correlation with PDGF levels
Conclusions: PRP led to enhanced bone regeneration and soft-tissue healing with former being directly related to higher concentration of PDGF-BB. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Rahul Verma Gita Negi Abhishek Kandwal Harish Chandra Dushyant Singh Gaur Meena Harsh Source Type: research

Flow cytometric enumeration of CD34 & #43; hematopoietic stem cells: A comparison between single- versus dual-platform methodology using the International Society of Hematotherapy and Graft Engineering protocol
Conclusion: In our study, both single versus dual platform had similar results in CD34+ cell counts. The single platform provides rapid results with ease of procedure. Errors with dual platforms are relatively common with respect to denominator. We recommend to use mean of total leukocyte count from two different hematology analyzer to minimize variation in dual platform. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Mohandoss Murugesan Chandran K Nair Sangeetha K Nayanar Kalyana Chakravarthy Pentapati Source Type: research

A guide to organize voluntary stem cell donors recruitment drive for hematopoietic progenitor stem cell transplant
Conclusions: Here, we have demonstrated guidelines along with steps to organize voluntary stem cell donors recruitment drive that is needed to increase number of donors, thus increasing significantly the chances of saving many vital lives. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Vikash Chandra Mishra Aseem K Tiwari Pranav Dorwal Vimarsh Raina Girish Sharma Source Type: research

Antibody screening and identification in donors and general patients at a tertiary care teaching hospital in Western India
Conclusion: Antibody screening and identification of specific alloantibody help in identifying most appropriate blood unit that lacks the corresponding antigen and prevent alloimmunization. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Kamini Parshuram Gupta Maitrey D Gajjar Tarak Ramesh Patel Nidhi Manish Bhatnagar Nihar Chaudhari Mamta Chintan Shah Source Type: research

High thermal amplitude auto-anti- & #8220;N & #8221; complicating pretransfusion compatibility tests on a patient with malaria and bladder cancer
Conclusion: Auto-anti-“N” as a cause of severe anemia could not be attributed to, for concurrent malarial infection. However, its presence may have some association with the underlying malignant condition. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Sanmukh R Joshi Ankita Sheladiya Vijaykumar N Agrawal Source Type: research

A study on factors influencing the hemostatic potential of fresh frozen plasma
Conclusion: Rapid freezing is recommended for optimum preservation of coagulation factors. Thawing may be done at 45°C in cases of emergency, without compromising hemostatic potential. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Lalit Dhantole Anju Dubey Atul Sonker Source Type: research

Impact of stored red cells on clinical outcome in critically ill
Conclusion: Critically ill patients may be prioritized for receiving fresher units of packed red cells preferably less than 21 days old. Transfusion is an independent risk factor for morbidity. Hence the risk to benefit ratio should be carefully assessed for every red cell transfusion in critically ill patients. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Aaditya Shivhare Shamee Shastry Mohandoss Murugesan Karishma Ashwin Doshi B Poornima Baliga Source Type: research

Effect of plateletpheresis on postdonation serum thrombopoietin levels and its correlation with platelet counts in healthy voluntary donors
Conclusion: Serum TPO levels increase significantly post plateletpheresis donation corresponding to decrease in platelet counts showing that TPO plays a vital role in compensatory mechanism after platelet loss. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Rekha Hans Ratti Ram Sharma Neelam Marwaha Source Type: research

Reducing delivery times of emergency blood products through pneumatic tube systems
Conclusions: Delivery of blood products by our modified PTS is safe and significantly reduces delivery time. This time savings could be clinically significant in resuscitation. Usage of the PTS could also cut down on workforce utilization of porters, freeing them up for other tasks in the hospital. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - June 12, 2019 Category: Hematology Authors: Jian Hao Jaryl Kok Choong Weng Leslie Lam Mee Yin Joanne Lee Source Type: research