Case report and strategies to mitigate passive hemolysis with platelet transfusions in children

We report here a case of a nine year old boy who received three units of mismatched platelet concentrates(PC) followed by acute hemolysis. On further investigation, one of the donors of the PC, who was typed as O positive, found to have high anti-A and anti-B titres of 1:128. This highlights the importance of matched platelet transfusions or modifying the product in pediatric setting, who are susceptible for passive hemolysis.
Source: Asian Journal of Transfusion Science - Category: Hematology Authors: Source Type: research