An inulin-type fructan CP-A from < em > Codonopsis pilosula < /em > alleviates TNBS-induced ulcerative colitis based on serum-untargeted metabolomics
Am J Physiol Gastrointest Liver Physiol. 2024 Jan 9. doi: 10.1152/ajpgi.00214.2023. Online ahead of print.ABSTRACTUlcerative colitis (UC) is an inflammatory disease with abdominal pain, diarrhea and bloody stool as the main symptoms. Several studies have confirmed that polysaccharides are effective against UC. It is commonly accepted that the traditional benefits of Radix Codonopsis can be attributed to its polysaccharide contents, and inulin-type fructan CP-A is the main active monomer in the polysaccharide components. Herein, we established a 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced UC rat model and lipopolys...
Source: Am J Physiol Gastroi... - January 9, 2024 Category: Gastroenterology Authors: Jiangtao Zhou Jiajing Wang Deyun Li Zhijia Zhang Changjian Wang Xuepeng Zhang Xiexin Xu Jianping Gao Source Type: research
Experimental colitis-induced visceral hypersensitivity is attenuated by GABA-treatment in mice
Am J Physiol Gastrointest Liver Physiol. 2024 Jan 9. doi: 10.1152/ajpgi.00012.2023. Online ahead of print.ABSTRACTUlcerative colitis (UC) is linked with inflammation of the large intestine due to an overactive response of the colon-immune system. UC is associated with weight loss, rectal bleeding, diarrhea, and abdominal pain. Given that GABA suppresses immune cell activity and the excitability of colonic afferents, and that there is a decrease in colonic GABA during UC, we hypothesized that UC-pain is due to a decrease in the inhibition of colonic afferents. Thus, restoring GABA in the colon will attenuate inflammatory hy...
Source: Am J Physiol Gastroi... - January 9, 2024 Category: Gastroenterology Authors: Michael S Gold Emanuel Loeza-Alcocer Source Type: research
FOXO3: at the crossroads of metabolic, inflammatory, and tumorigenic remodeling in the colon
Am J Physiol Gastrointest Liver Physiol. 2024 Jan 9. doi: 10.1152/ajpgi.00201.2023. Online ahead of print.ABSTRACTThe Forkhead box O3 (FOXO3) transcription factor regulates the expression of genes critical for diverse cellular functions in homeostasis. Diminished FOXO3 activity is associated with human diseases such as obesity, metabolic diseases, inflammatory diseases, and cancer. In the mouse colon, FOXO3 deficiency leads to an inflammatory immune landscape and dysregulated molecular pathways, which, under various insults, exacerbates inflammation and tumor burden, mimicking characteristics of human diseases. This defici...
Source: Am J Physiol Gastroi... - January 9, 2024 Category: Gastroenterology Authors: Patricia Snarski Jenisha Ghimire Suzana D Savkovic Source Type: research
Enteric Glial Cell Network Function is Required for Epithelial Barrier Restitution following Intestinal Ischemic Injury in the Early Postnatal Period
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 26. doi: 10.1152/ajpgi.00216.2022. Online ahead of print.ABSTRACTIschemic damage to the intestinal epithelial barrier, such as in necrotizing enterocolitis or small intestinal volvulus, is associated with higher mortality rates in younger patients. We have recently reported a powerful pig model to investigate these age-dependent outcomes in which mucosal barrier restitution is strikingly absent in neonates but can be rescued by direct application of homogenized mucosa from older, juvenile pigs by a yet-undefined mechanism. Within the mucosa, a postnatally developing network...
Source: Am J Physiol Gastroi... - December 26, 2023 Category: Gastroenterology Authors: Amanda L Ziegler Madison L Caldwell Sara J Erwin Emily A Hellstrom Anastasia E Sheridan Melissa S Touvron Tiffany A Pridgen Scott T Magness Jack Odle Laurianne Van Landeghem Anthony T Blikslager Source Type: research
Enteric Glial Cell Network Function is Required for Epithelial Barrier Restitution following Intestinal Ischemic Injury in the Early Postnatal Period
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 26. doi: 10.1152/ajpgi.00216.2022. Online ahead of print.ABSTRACTIschemic damage to the intestinal epithelial barrier, such as in necrotizing enterocolitis or small intestinal volvulus, is associated with higher mortality rates in younger patients. We have recently reported a powerful pig model to investigate these age-dependent outcomes in which mucosal barrier restitution is strikingly absent in neonates but can be rescued by direct application of homogenized mucosa from older, juvenile pigs by a yet-undefined mechanism. Within the mucosa, a postnatally developing network...
Source: Am J Physiol Gastroi... - December 26, 2023 Category: Gastroenterology Authors: Amanda L Ziegler Madison L Caldwell Sara J Erwin Emily A Hellstrom Anastasia E Sheridan Melissa S Touvron Tiffany A Pridgen Scott T Magness Jack Odle Laurianne Van Landeghem Anthony T Blikslager Source Type: research
Enteric Glial Cell Network Function is Required for Epithelial Barrier Restitution following Intestinal Ischemic Injury in the Early Postnatal Period
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 26. doi: 10.1152/ajpgi.00216.2022. Online ahead of print.ABSTRACTIschemic damage to the intestinal epithelial barrier, such as in necrotizing enterocolitis or small intestinal volvulus, is associated with higher mortality rates in younger patients. We have recently reported a powerful pig model to investigate these age-dependent outcomes in which mucosal barrier restitution is strikingly absent in neonates but can be rescued by direct application of homogenized mucosa from older, juvenile pigs by a yet-undefined mechanism. Within the mucosa, a postnatally developing network...
Source: Am J Physiol Gastroi... - December 26, 2023 Category: Gastroenterology Authors: Amanda L Ziegler Madison L Caldwell Sara J Erwin Emily A Hellstrom Anastasia E Sheridan Melissa S Touvron Tiffany A Pridgen Scott T Magness Jack Odle Laurianne Van Landeghem Anthony T Blikslager Source Type: research
Enteric Glial Cell Network Function is Required for Epithelial Barrier Restitution following Intestinal Ischemic Injury in the Early Postnatal Period
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 26. doi: 10.1152/ajpgi.00216.2022. Online ahead of print.ABSTRACTIschemic damage to the intestinal epithelial barrier, such as in necrotizing enterocolitis or small intestinal volvulus, is associated with higher mortality rates in younger patients. We have recently reported a powerful pig model to investigate these age-dependent outcomes in which mucosal barrier restitution is strikingly absent in neonates but can be rescued by direct application of homogenized mucosa from older, juvenile pigs by a yet-undefined mechanism. Within the mucosa, a postnatally developing network...
Source: Am J Physiol Gastroi... - December 26, 2023 Category: Gastroenterology Authors: Amanda L Ziegler Madison L Caldwell Sara J Erwin Emily A Hellstrom Anastasia E Sheridan Melissa S Touvron Tiffany A Pridgen Scott T Magness Jack Odle Laurianne Van Landeghem Anthony T Blikslager Source Type: research
Enteric Glial Cell Network Function is Required for Epithelial Barrier Restitution following Intestinal Ischemic Injury in the Early Postnatal Period
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 26. doi: 10.1152/ajpgi.00216.2022. Online ahead of print.ABSTRACTIschemic damage to the intestinal epithelial barrier, such as in necrotizing enterocolitis or small intestinal volvulus, is associated with higher mortality rates in younger patients. We have recently reported a powerful pig model to investigate these age-dependent outcomes in which mucosal barrier restitution is strikingly absent in neonates but can be rescued by direct application of homogenized mucosa from older, juvenile pigs by a yet-undefined mechanism. Within the mucosa, a postnatally developing network...
Source: Am J Physiol Gastroi... - December 26, 2023 Category: Gastroenterology Authors: Amanda L Ziegler Madison L Caldwell Sara J Erwin Emily A Hellstrom Anastasia E Sheridan Melissa S Touvron Tiffany A Pridgen Scott T Magness Jack Odle Laurianne Van Landeghem Anthony T Blikslager Source Type: research
Enteric Glial Cell Network Function is Required for Epithelial Barrier Restitution following Intestinal Ischemic Injury in the Early Postnatal Period
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 26. doi: 10.1152/ajpgi.00216.2022. Online ahead of print.ABSTRACTIschemic damage to the intestinal epithelial barrier, such as in necrotizing enterocolitis or small intestinal volvulus, is associated with higher mortality rates in younger patients. We have recently reported a powerful pig model to investigate these age-dependent outcomes in which mucosal barrier restitution is strikingly absent in neonates but can be rescued by direct application of homogenized mucosa from older, juvenile pigs by a yet-undefined mechanism. Within the mucosa, a postnatally developing network...
Source: Am J Physiol Gastroi... - December 26, 2023 Category: Gastroenterology Authors: Amanda L Ziegler Madison L Caldwell Sara J Erwin Emily A Hellstrom Anastasia E Sheridan Melissa S Touvron Tiffany A Pridgen Scott T Magness Jack Odle Laurianne Van Landeghem Anthony T Blikslager Source Type: research
Enteric Glial Cell Network Function is Required for Epithelial Barrier Restitution following Intestinal Ischemic Injury in the Early Postnatal Period
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 26. doi: 10.1152/ajpgi.00216.2022. Online ahead of print.ABSTRACTIschemic damage to the intestinal epithelial barrier, such as in necrotizing enterocolitis or small intestinal volvulus, is associated with higher mortality rates in younger patients. We have recently reported a powerful pig model to investigate these age-dependent outcomes in which mucosal barrier restitution is strikingly absent in neonates but can be rescued by direct application of homogenized mucosa from older, juvenile pigs by a yet-undefined mechanism. Within the mucosa, a postnatally developing network...
Source: Am J Physiol Gastroi... - December 26, 2023 Category: Gastroenterology Authors: Amanda L Ziegler Madison L Caldwell Sara J Erwin Emily A Hellstrom Anastasia E Sheridan Melissa S Touvron Tiffany A Pridgen Scott T Magness Jack Odle Laurianne Van Landeghem Anthony T Blikslager Source Type: research
Enteric Glial Cell Network Function is Required for Epithelial Barrier Restitution following Intestinal Ischemic Injury in the Early Postnatal Period
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 26. doi: 10.1152/ajpgi.00216.2022. Online ahead of print.ABSTRACTIschemic damage to the intestinal epithelial barrier, such as in necrotizing enterocolitis or small intestinal volvulus, is associated with higher mortality rates in younger patients. We have recently reported a powerful pig model to investigate these age-dependent outcomes in which mucosal barrier restitution is strikingly absent in neonates but can be rescued by direct application of homogenized mucosa from older, juvenile pigs by a yet-undefined mechanism. Within the mucosa, a postnatally developing network...
Source: Am J Physiol Gastroi... - December 26, 2023 Category: Gastroenterology Authors: Amanda L Ziegler Madison L Caldwell Sara J Erwin Emily A Hellstrom Anastasia E Sheridan Melissa S Touvron Tiffany A Pridgen Scott T Magness Jack Odle Laurianne Van Landeghem Anthony T Blikslager Source Type: research
Enteric Glial Cell Network Function is Required for Epithelial Barrier Restitution following Intestinal Ischemic Injury in the Early Postnatal Period
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 26. doi: 10.1152/ajpgi.00216.2022. Online ahead of print.ABSTRACTIschemic damage to the intestinal epithelial barrier, such as in necrotizing enterocolitis or small intestinal volvulus, is associated with higher mortality rates in younger patients. We have recently reported a powerful pig model to investigate these age-dependent outcomes in which mucosal barrier restitution is strikingly absent in neonates but can be rescued by direct application of homogenized mucosa from older, juvenile pigs by a yet-undefined mechanism. Within the mucosa, a postnatally developing network...
Source: Am J Physiol Gastroi... - December 26, 2023 Category: Gastroenterology Authors: Amanda L Ziegler Madison L Caldwell Sara J Erwin Emily A Hellstrom Anastasia E Sheridan Melissa S Touvron Tiffany A Pridgen Scott T Magness Jack Odle Laurianne Van Landeghem Anthony T Blikslager Source Type: research
Enteric Glial Cell Network Function is Required for Epithelial Barrier Restitution following Intestinal Ischemic Injury in the Early Postnatal Period
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 26. doi: 10.1152/ajpgi.00216.2022. Online ahead of print.ABSTRACTIschemic damage to the intestinal epithelial barrier, such as in necrotizing enterocolitis or small intestinal volvulus, is associated with higher mortality rates in younger patients. We have recently reported a powerful pig model to investigate these age-dependent outcomes in which mucosal barrier restitution is strikingly absent in neonates but can be rescued by direct application of homogenized mucosa from older, juvenile pigs by a yet-undefined mechanism. Within the mucosa, a postnatally developing network...
Source: Am J Physiol Gastroi... - December 26, 2023 Category: Gastroenterology Authors: Amanda L Ziegler Madison L Caldwell Sara J Erwin Emily A Hellstrom Anastasia E Sheridan Melissa S Touvron Tiffany A Pridgen Scott T Magness Jack Odle Laurianne Van Landeghem Anthony T Blikslager Source Type: research
Adiponectin affects ileal contractility of mouse preparations
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 19. doi: 10.1152/ajpgi.00203.2023. Online ahead of print.ABSTRACTAdiponectin (ADPN) has been reported to induce inhibitory effects on gastric motor activity which, being a source of peripheral satiety signals, would contribute to the central anorexigenic effects of the hormone in rodents. However, peripheral satiety signals can also originate from the small intestine. Since there are no data on the effects of ADPN in this gut region, the present study aimed to investigate whether ADPN affects murine ileal contractility. Immunofluorescence experiments and Western Blot were a...
Source: Am J Physiol Gastroi... - December 19, 2023 Category: Gastroenterology Authors: Eglantina Idrizaj Silvia Nistri Patrizia Nardini Maria Caterina Baccari Source Type: research
Alterations in descending brain-spinal pathways regulating colorectal motility in a rat model of Parkinson's disease
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 19. doi: 10.1152/ajpgi.00181.2023. Online ahead of print.ABSTRACTPatients with Parkinson's disease (PD) often have constipation. It is assumed that a disorder of the regulatory mechanism of colorectal motility by the central nervous system is involved in the constipation, but this remains unclear. The aim of this study was to investigate whether central neural pathways can modulate colorectal motility in a rat model of PD. PD model rats were generated by injection of 6-hydroxydopamine into a unilateral medial forebrain bundle and destruction of dopaminergic neurons in the s...
Source: Am J Physiol Gastroi... - December 19, 2023 Category: Gastroenterology Authors: Tomoya Sawamura Natsufu Yuki Kanae Aoki Kazuhiro Horii Yuuki Horii Kiyotada Naitou Shumpei Tsukamoto Takahiko Shiina Yasutake Shimizu Source Type: research
