Interaction between fatty acid oxidation and ethanol metabolism in liver
Am J Physiol Gastrointest Liver Physiol. 2024 May 1;326(5):G483-G494. doi: 10.1152/ajpgi.00281.2023. Epub 2024 Mar 5.ABSTRACTFatty acid oxidation (FAO) releases the energy stored in fat to maintain basic biological processes. Dehydrogenation is a major way to oxidize fatty acids, which needs NAD+ to accept the released H+ from fatty acids and form NADH, which increases the ratio of NADH/NAD+ and consequently inhibits FAO leading to the deposition of fat in the liver, which is termed fatty liver or steatosis. Consumption of alcohol (ethanol) initiates simple steatosis that progresses to alcoholic steatohepatitis, which cons...
Source: Am J Physiol Gastroi... - April 4, 2024 Category: Gastroenterology Authors: Yongke Lu Joseph George Source Type: research
Interaction between fatty acid oxidation and ethanol metabolism in liver
Am J Physiol Gastrointest Liver Physiol. 2024 May 1;326(5):G483-G494. doi: 10.1152/ajpgi.00281.2023. Epub 2024 Mar 5.ABSTRACTFatty acid oxidation (FAO) releases the energy stored in fat to maintain basic biological processes. Dehydrogenation is a major way to oxidize fatty acids, which needs NAD+ to accept the released H+ from fatty acids and form NADH, which increases the ratio of NADH/NAD+ and consequently inhibits FAO leading to the deposition of fat in the liver, which is termed fatty liver or steatosis. Consumption of alcohol (ethanol) initiates simple steatosis that progresses to alcoholic steatohepatitis, which cons...
Source: Am J Physiol Gastroi... - April 4, 2024 Category: Gastroenterology Authors: Yongke Lu Joseph George Source Type: research
Aryl Hydrocarbon Receptor Activity in Intestinal Epithelial Cells in the Formation of Colonic Tertiary Lymphoid Tissues
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 2. doi: 10.1152/ajpgi.00274.2023. Online ahead of print.ABSTRACTAfter birth, the development of secondary lymphoid tissues (SLTs) in the colon is dependent on the expression of the Aryl Hydrocarbon Receptor (AhR) in immune cells as a response to the availability of AhR ligands. However, little is known about how AhR activity from intestinal epithelial cells (IECs) may influence the development of tertiary lymphoid tissues (TLTs). As organized structures that develop at sites of inflammation or infection during adulthood, TLTs serve as localized centers of adaptive immune re...
Source: Am J Physiol Gastroi... - April 2, 2024 Category: Gastroenterology Authors: Erika Leonor Garcia-Villatoro Arinzechukwu Ufondu Evelyn S Callaway Kimberly Allred Stephen H Safe Robert S Chapkin Arul Jayaraman Clinton D Allred Source Type: research
Intestinal Perfusion of Unacylated Ghrelin Alleviated Metabolic Associated Fatty Liver Disease in Rat via a Central Glucagon-Like Peptide-1 Pathway
In conclusion, intestinal perfusion of UAG showed a therapeutic effect on MAFLD, which might be related to its activating on GLP-1 neuronal pathway from NTS to PVN. The present results provide a new strategy for the treatment of MAFLD.PMID:38564323 | DOI:10.1152/ajpgi.00217.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 2, 2024 Category: Gastroenterology Authors: Pengfei Lv Hongzeng Li Xiangbo Li Xueyuying Wang Jiantong Yu Yanling Gong Source Type: research
Aryl Hydrocarbon Receptor Activity in Intestinal Epithelial Cells in the Formation of Colonic Tertiary Lymphoid Tissues
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 2. doi: 10.1152/ajpgi.00274.2023. Online ahead of print.ABSTRACTAfter birth, the development of secondary lymphoid tissues (SLTs) in the colon is dependent on the expression of the Aryl Hydrocarbon Receptor (AhR) in immune cells as a response to the availability of AhR ligands. However, little is known about how AhR activity from intestinal epithelial cells (IECs) may influence the development of tertiary lymphoid tissues (TLTs). As organized structures that develop at sites of inflammation or infection during adulthood, TLTs serve as localized centers of adaptive immune re...
Source: Am J Physiol Gastroi... - April 2, 2024 Category: Gastroenterology Authors: Erika Leonor Garcia-Villatoro Arinzechukwu Ufondu Evelyn S Callaway Kimberly Allred Stephen H Safe Robert S Chapkin Arul Jayaraman Clinton D Allred Source Type: research
Intestinal Perfusion of Unacylated Ghrelin Alleviated Metabolic Associated Fatty Liver Disease in Rat via a Central Glucagon-Like Peptide-1 Pathway
In conclusion, intestinal perfusion of UAG showed a therapeutic effect on MAFLD, which might be related to its activating on GLP-1 neuronal pathway from NTS to PVN. The present results provide a new strategy for the treatment of MAFLD.PMID:38564323 | DOI:10.1152/ajpgi.00217.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - April 2, 2024 Category: Gastroenterology Authors: Pengfei Lv Hongzeng Li Xiangbo Li Xueyuying Wang Jiantong Yu Yanling Gong Source Type: research
Aryl Hydrocarbon Receptor Activity in Intestinal Epithelial Cells in the Formation of Colonic Tertiary Lymphoid Tissues
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 2. doi: 10.1152/ajpgi.00274.2023. Online ahead of print.ABSTRACTAfter birth, the development of secondary lymphoid tissues (SLTs) in the colon is dependent on the expression of the Aryl Hydrocarbon Receptor (AhR) in immune cells as a response to the availability of AhR ligands. However, little is known about how AhR activity from intestinal epithelial cells (IECs) may influence the development of tertiary lymphoid tissues (TLTs). As organized structures that develop at sites of inflammation or infection during adulthood, TLTs serve as localized centers of adaptive immune re...
Source: Am J Physiol Gastroi... - April 2, 2024 Category: Gastroenterology Authors: Erika Leonor Garcia-Villatoro Arinzechukwu Ufondu Evelyn S Callaway Kimberly Allred Stephen H Safe Robert S Chapkin Arul Jayaraman Clinton D Allred Source Type: research
< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research
Lower uromodulin serum levels are associated with poorer prognosis in patients with cirrhosis and hepatorenal syndrome type 2
This study aimed to evaluate the predictive value of serum levels of Uromodulin (sUMOD) in patients with cirrhosis and HRS treated with terlipressin and albumin (T/A). In total, 156 patients (81 patients with HRS treated with T/A, 42 patients with cirrhosis without kidney injury and 33 patients with cirrhosis with prerenal acute kidney injury (AKI)) were included. sUMOD levels were analysed by ELISA. Patients with HRS were prospectively followed for the composite endpoint of hemodialysis- / liver transplantation-free survival (HD/LTx-free survival). Of the 81 patients with HRS, 40 had HRS type 1 and 41 type 2. In the cohor...
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Eva Maria Schleicher Simon Johannes Gairing Darko Castven Charlotte Sophie Hock Henrike Dobbermann Sophia Heinrich Myriam Meineck Leonard Kaps Peter Robert Galle Julia Weinmann-Menke Marc Nguyen-Tat Jens Uwe Marquardt Christian Labenz Source Type: research
< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research
Lower uromodulin serum levels are associated with poorer prognosis in patients with cirrhosis and hepatorenal syndrome type 2
This study aimed to evaluate the predictive value of serum levels of Uromodulin (sUMOD) in patients with cirrhosis and HRS treated with terlipressin and albumin (T/A). In total, 156 patients (81 patients with HRS treated with T/A, 42 patients with cirrhosis without kidney injury and 33 patients with cirrhosis with prerenal acute kidney injury (AKI)) were included. sUMOD levels were analysed by ELISA. Patients with HRS were prospectively followed for the composite endpoint of hemodialysis- / liver transplantation-free survival (HD/LTx-free survival). Of the 81 patients with HRS, 40 had HRS type 1 and 41 type 2. In the cohor...
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Eva Maria Schleicher Simon Johannes Gairing Darko Castven Charlotte Sophie Hock Henrike Dobbermann Sophia Heinrich Myriam Meineck Leonard Kaps Peter Robert Galle Julia Weinmann-Menke Marc Nguyen-Tat Jens Uwe Marquardt Christian Labenz Source Type: research
< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research
Lower uromodulin serum levels are associated with poorer prognosis in patients with cirrhosis and hepatorenal syndrome type 2
This study aimed to evaluate the predictive value of serum levels of Uromodulin (sUMOD) in patients with cirrhosis and HRS treated with terlipressin and albumin (T/A). In total, 156 patients (81 patients with HRS treated with T/A, 42 patients with cirrhosis without kidney injury and 33 patients with cirrhosis with prerenal acute kidney injury (AKI)) were included. sUMOD levels were analysed by ELISA. Patients with HRS were prospectively followed for the composite endpoint of hemodialysis- / liver transplantation-free survival (HD/LTx-free survival). Of the 81 patients with HRS, 40 had HRS type 1 and 41 type 2. In the cohor...
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Eva Maria Schleicher Simon Johannes Gairing Darko Castven Charlotte Sophie Hock Henrike Dobbermann Sophia Heinrich Myriam Meineck Leonard Kaps Peter Robert Galle Julia Weinmann-Menke Marc Nguyen-Tat Jens Uwe Marquardt Christian Labenz Source Type: research
< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research
Lower uromodulin serum levels are associated with poorer prognosis in patients with cirrhosis and hepatorenal syndrome type 2
This study aimed to evaluate the predictive value of serum levels of Uromodulin (sUMOD) in patients with cirrhosis and HRS treated with terlipressin and albumin (T/A). In total, 156 patients (81 patients with HRS treated with T/A, 42 patients with cirrhosis without kidney injury and 33 patients with cirrhosis with prerenal acute kidney injury (AKI)) were included. sUMOD levels were analysed by ELISA. Patients with HRS were prospectively followed for the composite endpoint of hemodialysis- / liver transplantation-free survival (HD/LTx-free survival). Of the 81 patients with HRS, 40 had HRS type 1 and 41 type 2. In the cohor...
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Eva Maria Schleicher Simon Johannes Gairing Darko Castven Charlotte Sophie Hock Henrike Dobbermann Sophia Heinrich Myriam Meineck Leonard Kaps Peter Robert Galle Julia Weinmann-Menke Marc Nguyen-Tat Jens Uwe Marquardt Christian Labenz Source Type: research
