< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research
Lower uromodulin serum levels are associated with poorer prognosis in patients with cirrhosis and hepatorenal syndrome type 2
This study aimed to evaluate the predictive value of serum levels of Uromodulin (sUMOD) in patients with cirrhosis and HRS treated with terlipressin and albumin (T/A). In total, 156 patients (81 patients with HRS treated with T/A, 42 patients with cirrhosis without kidney injury and 33 patients with cirrhosis with prerenal acute kidney injury (AKI)) were included. sUMOD levels were analysed by ELISA. Patients with HRS were prospectively followed for the composite endpoint of hemodialysis- / liver transplantation-free survival (HD/LTx-free survival). Of the 81 patients with HRS, 40 had HRS type 1 and 41 type 2. In the cohor...
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Eva Maria Schleicher Simon Johannes Gairing Darko Castven Charlotte Sophie Hock Henrike Dobbermann Sophia Heinrich Myriam Meineck Leonard Kaps Peter Robert Galle Julia Weinmann-Menke Marc Nguyen-Tat Jens Uwe Marquardt Christian Labenz Source Type: research
< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research
Lower uromodulin serum levels are associated with poorer prognosis in patients with cirrhosis and hepatorenal syndrome type 2
This study aimed to evaluate the predictive value of serum levels of Uromodulin (sUMOD) in patients with cirrhosis and HRS treated with terlipressin and albumin (T/A). In total, 156 patients (81 patients with HRS treated with T/A, 42 patients with cirrhosis without kidney injury and 33 patients with cirrhosis with prerenal acute kidney injury (AKI)) were included. sUMOD levels were analysed by ELISA. Patients with HRS were prospectively followed for the composite endpoint of hemodialysis- / liver transplantation-free survival (HD/LTx-free survival). Of the 81 patients with HRS, 40 had HRS type 1 and 41 type 2. In the cohor...
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Eva Maria Schleicher Simon Johannes Gairing Darko Castven Charlotte Sophie Hock Henrike Dobbermann Sophia Heinrich Myriam Meineck Leonard Kaps Peter Robert Galle Julia Weinmann-Menke Marc Nguyen-Tat Jens Uwe Marquardt Christian Labenz Source Type: research
< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research
Lower uromodulin serum levels are associated with poorer prognosis in patients with cirrhosis and hepatorenal syndrome type 2
This study aimed to evaluate the predictive value of serum levels of Uromodulin (sUMOD) in patients with cirrhosis and HRS treated with terlipressin and albumin (T/A). In total, 156 patients (81 patients with HRS treated with T/A, 42 patients with cirrhosis without kidney injury and 33 patients with cirrhosis with prerenal acute kidney injury (AKI)) were included. sUMOD levels were analysed by ELISA. Patients with HRS were prospectively followed for the composite endpoint of hemodialysis- / liver transplantation-free survival (HD/LTx-free survival). Of the 81 patients with HRS, 40 had HRS type 1 and 41 type 2. In the cohor...
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Eva Maria Schleicher Simon Johannes Gairing Darko Castven Charlotte Sophie Hock Henrike Dobbermann Sophia Heinrich Myriam Meineck Leonard Kaps Peter Robert Galle Julia Weinmann-Menke Marc Nguyen-Tat Jens Uwe Marquardt Christian Labenz Source Type: research
< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research
Lower uromodulin serum levels are associated with poorer prognosis in patients with cirrhosis and hepatorenal syndrome type 2
This study aimed to evaluate the predictive value of serum levels of Uromodulin (sUMOD) in patients with cirrhosis and HRS treated with terlipressin and albumin (T/A). In total, 156 patients (81 patients with HRS treated with T/A, 42 patients with cirrhosis without kidney injury and 33 patients with cirrhosis with prerenal acute kidney injury (AKI)) were included. sUMOD levels were analysed by ELISA. Patients with HRS were prospectively followed for the composite endpoint of hemodialysis- / liver transplantation-free survival (HD/LTx-free survival). Of the 81 patients with HRS, 40 had HRS type 1 and 41 type 2. In the cohor...
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Eva Maria Schleicher Simon Johannes Gairing Darko Castven Charlotte Sophie Hock Henrike Dobbermann Sophia Heinrich Myriam Meineck Leonard Kaps Peter Robert Galle Julia Weinmann-Menke Marc Nguyen-Tat Jens Uwe Marquardt Christian Labenz Source Type: research
< em > Bacteroides thetaiotaomicron < /em > and < em > Faecalibacterium prausnitzii < /em > served as key components of fecal microbiota transplantation to alleviate colitis
In conclusion, B. thetaiotaomicron and F. prausnitzii, as the key bacteria in donor feces, alleviate colitis in mice. The mechanism may involve increasing lecithin and regulating IL-10 production of intestinal Tregs.PMID:38502145 | DOI:10.1152/ajpgi.00303.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Binqiang Xu Yang Fu Nuoming Yin Wenfei Qin Zehua Huang Wei Xiao Huizhen Huang Qixiang Mei Junjie Fan Yue Zeng Chunlan Huang Source Type: research
Lower uromodulin serum levels are associated with poorer prognosis in patients with cirrhosis and hepatorenal syndrome type 2
This study aimed to evaluate the predictive value of serum levels of Uromodulin (sUMOD) in patients with cirrhosis and HRS treated with terlipressin and albumin (T/A). In total, 156 patients (81 patients with HRS treated with T/A, 42 patients with cirrhosis without kidney injury and 33 patients with cirrhosis with prerenal acute kidney injury (AKI)) were included. sUMOD levels were analysed by ELISA. Patients with HRS were prospectively followed for the composite endpoint of hemodialysis- / liver transplantation-free survival (HD/LTx-free survival). Of the 81 patients with HRS, 40 had HRS type 1 and 41 type 2. In the cohor...
Source: Am J Physiol Gastroi... - March 19, 2024 Category: Gastroenterology Authors: Eva Maria Schleicher Simon Johannes Gairing Darko Castven Charlotte Sophie Hock Henrike Dobbermann Sophia Heinrich Myriam Meineck Leonard Kaps Peter Robert Galle Julia Weinmann-Menke Marc Nguyen-Tat Jens Uwe Marquardt Christian Labenz Source Type: research
Albumin promoter-driven FlpO expression induces efficient genetic recombination in mouse liver
CONCLUSIONS: A highly efficient and liver-specific BAC-Alb-FlpO mouse model was developed. In combination with other Cre lines, different genes can be manipulated sequentially in the same cell, or distinct genetic changes can be induced in different cell types of the same organism.PMID:38469630 | DOI:10.1152/ajpgi.00263.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - March 12, 2024 Category: Gastroenterology Authors: Xiaohui Zhu Yan Yang Dongfeng Feng Oliver Wang Jiaxiang Chen Jiale Wang Bin Wang Yang Liu Brandy H Edenfield Ashley N Haddock Ying Wang Tushar Patel Yan Bi Baoan Ji Source Type: research
Panaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters the immune response to mitigate colitis
This study builds on our initial data, which showed that panaxynol - a novel, potent, bioavailable compound found in American ginseng - can suppress disease severity in murine colitis. Here we explore the underlying mechanisms by which panaxynol improves both chronic and acute murine colitis. 14-week-old C57BL/6 female mice were either given 3 rounds of dextran sulfate sodium (DSS) in drinking water to induce chronic colitis or 1 round to induce acute colitis. Vehicle or panaxynol (2.5 mg/kg) was administered via oral gavage 3x/week for the study duration. Consistent with our previous findings, panaxynol significantly (p&l...
Source: Am J Physiol Gastroi... - March 12, 2024 Category: Gastroenterology Authors: Brooke M Bullard Sierra J McDonald Thomas D Cardaci Brandon N VanderVeen Ahmed D Mohammed Jason L Kubinak Joseph F Pierre Ioulia Chatzistamou Daping Fan Lorne J Hofseth E Angela Murphy Source Type: research
Albumin promoter-driven FlpO expression induces efficient genetic recombination in mouse liver
CONCLUSIONS: A highly efficient and liver-specific BAC-Alb-FlpO mouse model was developed. In combination with other Cre lines, different genes can be manipulated sequentially in the same cell, or distinct genetic changes can be induced in different cell types of the same organism.PMID:38469630 | DOI:10.1152/ajpgi.00263.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - March 12, 2024 Category: Gastroenterology Authors: Xiaohui Zhu Yan Yang Dongfeng Feng Oliver Wang Jiaxiang Chen Jiale Wang Bin Wang Yang Liu Brandy H Edenfield Ashley N Haddock Ying Wang Tushar Patel Yan Bi Baoan Ji Source Type: research
Panaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters the immune response to mitigate colitis
This study builds on our initial data, which showed that panaxynol - a novel, potent, bioavailable compound found in American ginseng - can suppress disease severity in murine colitis. Here we explore the underlying mechanisms by which panaxynol improves both chronic and acute murine colitis. 14-week-old C57BL/6 female mice were either given 3 rounds of dextran sulfate sodium (DSS) in drinking water to induce chronic colitis or 1 round to induce acute colitis. Vehicle or panaxynol (2.5 mg/kg) was administered via oral gavage 3x/week for the study duration. Consistent with our previous findings, panaxynol significantly (p&l...
Source: Am J Physiol Gastroi... - March 12, 2024 Category: Gastroenterology Authors: Brooke M Bullard Sierra J McDonald Thomas D Cardaci Brandon N VanderVeen Ahmed D Mohammed Jason L Kubinak Joseph F Pierre Ioulia Chatzistamou Daping Fan Lorne J Hofseth E Angela Murphy Source Type: research
Albumin promoter-driven FlpO expression induces efficient genetic recombination in mouse liver
CONCLUSIONS: A highly efficient and liver-specific BAC-Alb-FlpO mouse model was developed. In combination with other Cre lines, different genes can be manipulated sequentially in the same cell, or distinct genetic changes can be induced in different cell types of the same organism.PMID:38469630 | DOI:10.1152/ajpgi.00263.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - March 12, 2024 Category: Gastroenterology Authors: Xiaohui Zhu Yan Yang Dongfeng Feng Oliver Wang Jiaxiang Chen Jiale Wang Bin Wang Yang Liu Brandy H Edenfield Ashley N Haddock Ying Wang Tushar Patel Yan Bi Baoan Ji Source Type: research
