Alterations in descending brain-spinal pathways regulating colorectal motility in a rat model of Parkinson's disease
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 19. doi: 10.1152/ajpgi.00181.2023. Online ahead of print.ABSTRACTPatients with Parkinson's disease (PD) often have constipation. It is assumed that a disorder of the regulatory mechanism of colorectal motility by the central nervous system is involved in the constipation, but this remains unclear. The aim of this study was to investigate whether central neural pathways can modulate colorectal motility in a rat model of PD. PD model rats were generated by injection of 6-hydroxydopamine into a unilateral medial forebrain bundle and destruction of dopaminergic neurons in the s...
Source: Am J Physiol Gastroi... - December 19, 2023 Category: Gastroenterology Authors: Tomoya Sawamura Natsufu Yuki Kanae Aoki Kazuhiro Horii Yuuki Horii Kiyotada Naitou Shumpei Tsukamoto Takahiko Shiina Yasutake Shimizu Source Type: research
Adiponectin affects ileal contractility of mouse preparations
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 19. doi: 10.1152/ajpgi.00203.2023. Online ahead of print.ABSTRACTAdiponectin (ADPN) has been reported to induce inhibitory effects on gastric motor activity which, being a source of peripheral satiety signals, would contribute to the central anorexigenic effects of the hormone in rodents. However, peripheral satiety signals can also originate from the small intestine. Since there are no data on the effects of ADPN in this gut region, the present study aimed to investigate whether ADPN affects murine ileal contractility. Immunofluorescence experiments and Western Blot were a...
Source: Am J Physiol Gastroi... - December 19, 2023 Category: Gastroenterology Authors: Eglantina Idrizaj Silvia Nistri Patrizia Nardini Maria Caterina Baccari Source Type: research
Alterations in descending brain-spinal pathways regulating colorectal motility in a rat model of Parkinson's disease
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 19. doi: 10.1152/ajpgi.00181.2023. Online ahead of print.ABSTRACTPatients with Parkinson's disease (PD) often have constipation. It is assumed that a disorder of the regulatory mechanism of colorectal motility by the central nervous system is involved in the constipation, but this remains unclear. The aim of this study was to investigate whether central neural pathways can modulate colorectal motility in a rat model of PD. PD model rats were generated by injection of 6-hydroxydopamine into a unilateral medial forebrain bundle and destruction of dopaminergic neurons in the s...
Source: Am J Physiol Gastroi... - December 19, 2023 Category: Gastroenterology Authors: Tomoya Sawamura Natsufu Yuki Kanae Aoki Kazuhiro Horii Yuuki Horii Kiyotada Naitou Shumpei Tsukamoto Takahiko Shiina Yasutake Shimizu Source Type: research
Adiponectin affects ileal contractility of mouse preparations
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 19. doi: 10.1152/ajpgi.00203.2023. Online ahead of print.ABSTRACTAdiponectin (ADPN) has been reported to induce inhibitory effects on gastric motor activity which, being a source of peripheral satiety signals, would contribute to the central anorexigenic effects of the hormone in rodents. However, peripheral satiety signals can also originate from the small intestine. Since there are no data on the effects of ADPN in this gut region, the present study aimed to investigate whether ADPN affects murine ileal contractility. Immunofluorescence experiments and Western Blot were a...
Source: Am J Physiol Gastroi... - December 19, 2023 Category: Gastroenterology Authors: Eglantina Idrizaj Silvia Nistri Patrizia Nardini Maria Caterina Baccari Source Type: research
Alterations in descending brain-spinal pathways regulating colorectal motility in a rat model of Parkinson's disease
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 19. doi: 10.1152/ajpgi.00181.2023. Online ahead of print.ABSTRACTPatients with Parkinson's disease (PD) often have constipation. It is assumed that a disorder of the regulatory mechanism of colorectal motility by the central nervous system is involved in the constipation, but this remains unclear. The aim of this study was to investigate whether central neural pathways can modulate colorectal motility in a rat model of PD. PD model rats were generated by injection of 6-hydroxydopamine into a unilateral medial forebrain bundle and destruction of dopaminergic neurons in the s...
Source: Am J Physiol Gastroi... - December 19, 2023 Category: Gastroenterology Authors: Tomoya Sawamura Natsufu Yuki Kanae Aoki Kazuhiro Horii Yuuki Horii Kiyotada Naitou Shumpei Tsukamoto Takahiko Shiina Yasutake Shimizu Source Type: research
Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 12. doi: 10.1152/ajpgi.00230.2023. Online ahead of print.ABSTRACTAbdominal pain is a cardinal symptom of inflammatory bowel disease (IBD). Transient receptor potential (TRP) channels contribute to abdominal pain in preclinical models of IBD, and TRP melastatin 3 (TRPM3) has recently been implicated in inflammatory bladder and joint pain in rodents. We hypothesized that TRPM3 is involved in colonic sensation and is sensitized during colitis. We utilized immunohistochemistry, ratiometric Ca2+ imaging, and colonic afferent nerve recordings in mice to evaluate TRPM3 protein exp...
Source: Am J Physiol Gastroi... - December 12, 2023 Category: Gastroenterology Authors: James W King Aidan S W Bennett Hannah M Wood Corey C Baker Hanin Alsaadi Max Topley Stephen A Vanner David E Reed Alan E Lomax Source Type: research
Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 12. doi: 10.1152/ajpgi.00230.2023. Online ahead of print.ABSTRACTAbdominal pain is a cardinal symptom of inflammatory bowel disease (IBD). Transient receptor potential (TRP) channels contribute to abdominal pain in preclinical models of IBD, and TRP melastatin 3 (TRPM3) has recently been implicated in inflammatory bladder and joint pain in rodents. We hypothesized that TRPM3 is involved in colonic sensation and is sensitized during colitis. We utilized immunohistochemistry, ratiometric Ca2+ imaging, and colonic afferent nerve recordings in mice to evaluate TRPM3 protein exp...
Source: Am J Physiol Gastroi... - December 12, 2023 Category: Gastroenterology Authors: James W King Aidan S W Bennett Hannah M Wood Corey C Baker Hanin Alsaadi Max Topley Stephen A Vanner David E Reed Alan E Lomax Source Type: research
Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 12. doi: 10.1152/ajpgi.00230.2023. Online ahead of print.ABSTRACTAbdominal pain is a cardinal symptom of inflammatory bowel disease (IBD). Transient receptor potential (TRP) channels contribute to abdominal pain in preclinical models of IBD, and TRP melastatin 3 (TRPM3) has recently been implicated in inflammatory bladder and joint pain in rodents. We hypothesized that TRPM3 is involved in colonic sensation and is sensitized during colitis. We utilized immunohistochemistry, ratiometric Ca2+ imaging, and colonic afferent nerve recordings in mice to evaluate TRPM3 protein exp...
Source: Am J Physiol Gastroi... - December 12, 2023 Category: Gastroenterology Authors: James W King Aidan S W Bennett Hannah M Wood Corey C Baker Hanin Alsaadi Max Topley Stephen A Vanner David E Reed Alan E Lomax Source Type: research
Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 12. doi: 10.1152/ajpgi.00230.2023. Online ahead of print.ABSTRACTAbdominal pain is a cardinal symptom of inflammatory bowel disease (IBD). Transient receptor potential (TRP) channels contribute to abdominal pain in preclinical models of IBD, and TRP melastatin 3 (TRPM3) has recently been implicated in inflammatory bladder and joint pain in rodents. We hypothesized that TRPM3 is involved in colonic sensation and is sensitized during colitis. We utilized immunohistochemistry, ratiometric Ca2+ imaging, and colonic afferent nerve recordings in mice to evaluate TRPM3 protein exp...
Source: Am J Physiol Gastroi... - December 12, 2023 Category: Gastroenterology Authors: James W King Aidan S W Bennett Hannah M Wood Corey C Baker Hanin Alsaadi Max Topley Stephen A Vanner David E Reed Alan E Lomax Source Type: research
Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 12. doi: 10.1152/ajpgi.00230.2023. Online ahead of print.ABSTRACTAbdominal pain is a cardinal symptom of inflammatory bowel disease (IBD). Transient receptor potential (TRP) channels contribute to abdominal pain in preclinical models of IBD, and TRP melastatin 3 (TRPM3) has recently been implicated in inflammatory bladder and joint pain in rodents. We hypothesized that TRPM3 is involved in colonic sensation and is sensitized during colitis. We utilized immunohistochemistry, ratiometric Ca2+ imaging, and colonic afferent nerve recordings in mice to evaluate TRPM3 protein exp...
Source: Am J Physiol Gastroi... - December 12, 2023 Category: Gastroenterology Authors: James W King Aidan S W Bennett Hannah M Wood Corey C Baker Hanin Alsaadi Max Topley Stephen A Vanner David E Reed Alan E Lomax Source Type: research
Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon
Am J Physiol Gastrointest Liver Physiol. 2023 Dec 12. doi: 10.1152/ajpgi.00230.2023. Online ahead of print.ABSTRACTAbdominal pain is a cardinal symptom of inflammatory bowel disease (IBD). Transient receptor potential (TRP) channels contribute to abdominal pain in preclinical models of IBD, and TRP melastatin 3 (TRPM3) has recently been implicated in inflammatory bladder and joint pain in rodents. We hypothesized that TRPM3 is involved in colonic sensation and is sensitized during colitis. We utilized immunohistochemistry, ratiometric Ca2+ imaging, and colonic afferent nerve recordings in mice to evaluate TRPM3 protein exp...
Source: Am J Physiol Gastroi... - December 12, 2023 Category: Gastroenterology Authors: James W King Aidan S W Bennett Hannah M Wood Corey C Baker Hanin Alsaadi Max Topley Stephen A Vanner David E Reed Alan E Lomax Source Type: research
Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization
In this study, we systematically assessed sex differences in colorectal neural encoding by conducting high-throughput optical recordings in intact dorsal root ganglia (DRGs) from control and visceral hypersensitive mice. We found an apparent sex difference in zymosan-induced behavioral visceral hypersensitivity: enhanced visceromotor responses to colorectal distension were observed only in male mice, not in female mice. Additionally, a higher number of mechanosensitive colorectal afferents were identified per mouse in the zymosan-treated male group than in the saline-treated male group, whereas the mechanosensitive afferen...
Source: Am J Physiol Gastroi... - December 5, 2023 Category: Gastroenterology Authors: Tiantian Guo Jia Liu Longtu Chen Zichao Bian Guoan Zheng Bin Feng Source Type: research
Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization
In this study, we systematically assessed sex differences in colorectal neural encoding by conducting high-throughput optical recordings in intact dorsal root ganglia (DRGs) from control and visceral hypersensitive mice. We found an apparent sex difference in zymosan-induced behavioral visceral hypersensitivity: enhanced visceromotor responses to colorectal distension were observed only in male mice, not in female mice. Additionally, a higher number of mechanosensitive colorectal afferents were identified per mouse in the zymosan-treated male group than in the saline-treated male group, whereas the mechanosensitive afferen...
Source: Am J Physiol Gastroi... - December 5, 2023 Category: Gastroenterology Authors: Tiantian Guo Jia Liu Longtu Chen Zichao Bian Guoan Zheng Bin Feng Source Type: research
Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization
In this study, we systematically assessed sex differences in colorectal neural encoding by conducting high-throughput optical recordings in intact dorsal root ganglia (DRGs) from control and visceral hypersensitive mice. We found an apparent sex difference in zymosan-induced behavioral visceral hypersensitivity: enhanced visceromotor responses to colorectal distension were observed only in male mice, not in female mice. Additionally, a higher number of mechanosensitive colorectal afferents were identified per mouse in the zymosan-treated male group than in the saline-treated male group, whereas the mechanosensitive afferen...
Source: Am J Physiol Gastroi... - December 5, 2023 Category: Gastroenterology Authors: Tiantian Guo Jia Liu Longtu Chen Zichao Bian Guoan Zheng Bin Feng Source Type: research
Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization
In this study, we systematically assessed sex differences in colorectal neural encoding by conducting high-throughput optical recordings in intact dorsal root ganglia (DRGs) from control and visceral hypersensitive mice. We found an apparent sex difference in zymosan-induced behavioral visceral hypersensitivity: enhanced visceromotor responses to colorectal distension were observed only in male mice, not in female mice. Additionally, a higher number of mechanosensitive colorectal afferents were identified per mouse in the zymosan-treated male group than in the saline-treated male group, whereas the mechanosensitive afferen...
Source: Am J Physiol Gastroi... - December 5, 2023 Category: Gastroenterology Authors: Tiantian Guo Jia Liu Longtu Chen Zichao Bian Guoan Zheng Bin Feng Source Type: research
