Cholestenoic Acid as Endogenous Epigenetic Regulator Decreases Hepatocyte Lipid Accumulation in Vitro and in Vivo
This study shows that CA as an endogenous epigenetic regulator decreases lipid accumulation via epigenetic regulation. The results indicate that CA can be considered a potential therapeutic target for the treatment of metabolic disorders.PMID:37961761 | DOI:10.1152/ajpgi.00184.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - November 14, 2023 Category: Gastroenterology Authors: Yaping Wang William M Pandak Phillip B Hylemon Hae-Ki Min John Min Michael Fuchs Arun J Sanyal Shunlin Ren Source Type: research
Intestinal ultrasound, an underutilized tool for assessing colonic motility
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 14. doi: 10.1152/ajpgi.00237.2023. Online ahead of print.NO ABSTRACTPMID:37961815 | DOI:10.1152/ajpgi.00237.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - November 14, 2023 Category: Gastroenterology Authors: Gabrio Bassotti Giovanni Maconi Source Type: research
Defining a timeline of colon pathologies after keratin 8 loss: Rapid crypt elongation and diarrhea are followed by epithelial erosion and cell exfoliation
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 14. doi: 10.1152/ajpgi.00140.2023. Online ahead of print.ABSTRACTKeratins are epithelial intermediate filament proteins that play a crucial role in cellular stress protection, with K8 being the most abundant in the colon. The intestinal epithelial-specific K8-deficient mouse model (K8flox/flox;Villin-Cre) exhibits characteristics of inflammatory bowel disease, including diarrhea, crypt erosion, hyperproliferation and decreased barrier function. Nevertheless, the order in which these events occur and whether they are a direct cause of K8 loss or a consequence of one event in...
Source: Am J Physiol Gastroi... - November 14, 2023 Category: Gastroenterology Authors: Maria A Ilom äki Lauri Polari Carl-Gustaf A Stenvall Mina Tayyab Kirah K ähärä Karen M Ridge Diana M Toivola Source Type: research
Disruption of hypoxia inducible factor-2 α in neutrophils decreases colitis-associated colon cancer
In conclusion, we found that the loss of neutrophil-specific HIF-2α slows colon tumor growth and progression by reducing the levels of inflammatory mediators.PMID:37933447 | DOI:10.1152/ajpgi.00182.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - November 7, 2023 Category: Gastroenterology Authors: Rashi Singhal Nikhil Kumar Kotla Sumeet Solanki Wesley Huang Hannah N Bell Marwa O Elderany Cristina Castillo Yatrik M Shah Source Type: research
Th2 Cytokine Signaling through IL-4R α Increases Eotaxin-3 Secretion and Tension in Human Esophageal Smooth Muscle
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 7. doi: 10.1152/ajpgi.00155.2023. Online ahead of print.ABSTRACTIn esophageal epithelial cells in eosinophilic esophagitis (EoE), Th2 cytokines (IL-4, IL-13) signal through IL-4Rα, activating JAK to increase eotaxin-3 secretion, which draws eosinophils into the mucosa. We explored whether Th2 cytokines also might stimulate eotaxin-3 secretion and increase tension in esophageal smooth muscle (ESM), which might impair esophageal distensibility, and whether those events could be blocked by PPIs or agents that disrupt IL-4Rα signaling. We established human ESM cell cultures f...
Source: Am J Physiol Gastroi... - November 7, 2023 Category: Gastroenterology Authors: Melissa R Nelson Xi Zhang Eitan Podgaetz Xuan Wang Qiuyang Zhang Zui Pan Stuart Jon Spechler Rhonda F Souza Source Type: research
< em > Clostridium scindens < /em > exacerbates experimental necrotizing enterocolitis via upregulation of the apical sodium dependent bile acid transporter
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 7. doi: 10.1152/ajpgi.00102.2023. Online ahead of print.ABSTRACTNecrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in premature infants. Evidence indicates that bile acid homeostasis is disrupted during NEC: ileal bile acid levels are elevated in animals with experimental NEC, as is expression of the apical sodium dependent bile acid transporter (Asbt). In addition, bile acids-which are synthesized in the liver-are extensively modified by the gut microbiome, including via conversion of primary bile acids to more cytotoxic secondary forms. We hypot...
Source: Am J Physiol Gastroi... - November 7, 2023 Category: Gastroenterology Authors: Christine M Calton Katelyn Carothers Shylaja Ramamurthy Neha Jagadish Bhumika Phanindra Anett Garcia V K Viswanathan Melissa D Halpern Source Type: research
Disruption of hypoxia inducible factor-2 α in neutrophils decreases colitis-associated colon cancer
In conclusion, we found that the loss of neutrophil-specific HIF-2α slows colon tumor growth and progression by reducing the levels of inflammatory mediators.PMID:37933447 | DOI:10.1152/ajpgi.00182.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - November 7, 2023 Category: Gastroenterology Authors: Rashi Singhal Nikhil Kumar Kotla Sumeet Solanki Wesley Huang Hannah N Bell Marwa O Elderany Cristina Castillo Yatrik M Shah Source Type: research
Th2 Cytokine Signaling through IL-4R α Increases Eotaxin-3 Secretion and Tension in Human Esophageal Smooth Muscle
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 7. doi: 10.1152/ajpgi.00155.2023. Online ahead of print.ABSTRACTIn esophageal epithelial cells in eosinophilic esophagitis (EoE), Th2 cytokines (IL-4, IL-13) signal through IL-4Rα, activating JAK to increase eotaxin-3 secretion, which draws eosinophils into the mucosa. We explored whether Th2 cytokines also might stimulate eotaxin-3 secretion and increase tension in esophageal smooth muscle (ESM), which might impair esophageal distensibility, and whether those events could be blocked by PPIs or agents that disrupt IL-4Rα signaling. We established human ESM cell cultures f...
Source: Am J Physiol Gastroi... - November 7, 2023 Category: Gastroenterology Authors: Melissa R Nelson Xi Zhang Eitan Podgaetz Xuan Wang Qiuyang Zhang Zui Pan Stuart Jon Spechler Rhonda F Souza Source Type: research
< em > Clostridium scindens < /em > exacerbates experimental necrotizing enterocolitis via upregulation of the apical sodium dependent bile acid transporter
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 7. doi: 10.1152/ajpgi.00102.2023. Online ahead of print.ABSTRACTNecrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in premature infants. Evidence indicates that bile acid homeostasis is disrupted during NEC: ileal bile acid levels are elevated in animals with experimental NEC, as is expression of the apical sodium dependent bile acid transporter (Asbt). In addition, bile acids-which are synthesized in the liver-are extensively modified by the gut microbiome, including via conversion of primary bile acids to more cytotoxic secondary forms. We hypot...
Source: Am J Physiol Gastroi... - November 7, 2023 Category: Gastroenterology Authors: Christine M Calton Katelyn Carothers Shylaja Ramamurthy Neha Jagadish Bhumika Phanindra Anett Garcia V K Viswanathan Melissa D Halpern Source Type: research
Disruption of hypoxia inducible factor-2 α in neutrophils decreases colitis-associated colon cancer
In conclusion, we found that the loss of neutrophil-specific HIF-2α slows colon tumor growth and progression by reducing the levels of inflammatory mediators.PMID:37933447 | DOI:10.1152/ajpgi.00182.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - November 7, 2023 Category: Gastroenterology Authors: Rashi Singhal Nikhil Kumar Kotla Sumeet Solanki Wesley Huang Hannah N Bell Marwa O Elderany Cristina Castillo Yatrik M Shah Source Type: research
Th2 Cytokine Signaling through IL-4R α Increases Eotaxin-3 Secretion and Tension in Human Esophageal Smooth Muscle
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 7. doi: 10.1152/ajpgi.00155.2023. Online ahead of print.ABSTRACTIn esophageal epithelial cells in eosinophilic esophagitis (EoE), Th2 cytokines (IL-4, IL-13) signal through IL-4Rα, activating JAK to increase eotaxin-3 secretion, which draws eosinophils into the mucosa. We explored whether Th2 cytokines also might stimulate eotaxin-3 secretion and increase tension in esophageal smooth muscle (ESM), which might impair esophageal distensibility, and whether those events could be blocked by PPIs or agents that disrupt IL-4Rα signaling. We established human ESM cell cultures f...
Source: Am J Physiol Gastroi... - November 7, 2023 Category: Gastroenterology Authors: Melissa R Nelson Xi Zhang Eitan Podgaetz Xuan Wang Qiuyang Zhang Zui Pan Stuart Jon Spechler Rhonda F Souza Source Type: research
< em > Clostridium scindens < /em > exacerbates experimental necrotizing enterocolitis via upregulation of the apical sodium dependent bile acid transporter
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 7. doi: 10.1152/ajpgi.00102.2023. Online ahead of print.ABSTRACTNecrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in premature infants. Evidence indicates that bile acid homeostasis is disrupted during NEC: ileal bile acid levels are elevated in animals with experimental NEC, as is expression of the apical sodium dependent bile acid transporter (Asbt). In addition, bile acids-which are synthesized in the liver-are extensively modified by the gut microbiome, including via conversion of primary bile acids to more cytotoxic secondary forms. We hypot...
Source: Am J Physiol Gastroi... - November 7, 2023 Category: Gastroenterology Authors: Christine M Calton Katelyn Carothers Shylaja Ramamurthy Neha Jagadish Bhumika Phanindra Anett Garcia V K Viswanathan Melissa D Halpern Source Type: research
Disruption of hypoxia inducible factor-2 α in neutrophils decreases colitis-associated colon cancer
In conclusion, we found that the loss of neutrophil-specific HIF-2α slows colon tumor growth and progression by reducing the levels of inflammatory mediators.PMID:37933447 | DOI:10.1152/ajpgi.00182.2023 (Source: Am J Physiol Gastroi...)
Source: Am J Physiol Gastroi... - November 7, 2023 Category: Gastroenterology Authors: Rashi Singhal Nikhil Kumar Kotla Sumeet Solanki Wesley Huang Hannah N Bell Marwa O Elderany Cristina Castillo Yatrik M Shah Source Type: research
Th2 Cytokine Signaling through IL-4R α Increases Eotaxin-3 Secretion and Tension in Human Esophageal Smooth Muscle
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 7. doi: 10.1152/ajpgi.00155.2023. Online ahead of print.ABSTRACTIn esophageal epithelial cells in eosinophilic esophagitis (EoE), Th2 cytokines (IL-4, IL-13) signal through IL-4Rα, activating JAK to increase eotaxin-3 secretion, which draws eosinophils into the mucosa. We explored whether Th2 cytokines also might stimulate eotaxin-3 secretion and increase tension in esophageal smooth muscle (ESM), which might impair esophageal distensibility, and whether those events could be blocked by PPIs or agents that disrupt IL-4Rα signaling. We established human ESM cell cultures f...
Source: Am J Physiol Gastroi... - November 7, 2023 Category: Gastroenterology Authors: Melissa R Nelson Xi Zhang Eitan Podgaetz Xuan Wang Qiuyang Zhang Zui Pan Stuart Jon Spechler Rhonda F Souza Source Type: research
< em > Clostridium scindens < /em > exacerbates experimental necrotizing enterocolitis via upregulation of the apical sodium dependent bile acid transporter
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 7. doi: 10.1152/ajpgi.00102.2023. Online ahead of print.ABSTRACTNecrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in premature infants. Evidence indicates that bile acid homeostasis is disrupted during NEC: ileal bile acid levels are elevated in animals with experimental NEC, as is expression of the apical sodium dependent bile acid transporter (Asbt). In addition, bile acids-which are synthesized in the liver-are extensively modified by the gut microbiome, including via conversion of primary bile acids to more cytotoxic secondary forms. We hypot...
Source: Am J Physiol Gastroi... - November 7, 2023 Category: Gastroenterology Authors: Christine M Calton Katelyn Carothers Shylaja Ramamurthy Neha Jagadish Bhumika Phanindra Anett Garcia V K Viswanathan Melissa D Halpern Source Type: research
