The distribution of purinergic receptors, P2Y and P2X, expression within the intestine
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 21. doi: 10.1152/ajpgi.00108.2023. Online ahead of print.ABSTRACTNucleotides are potent extracellular signaling molecules during homeostasis, infection, and injury due to their ability to activate purinergic receptors. The nucleotide ATP activates P2X receptors (P2RXs), while the nucleotides ADP, ATP, UTP and UDP-glucose selectively activate different P2Y receptors (P2RYs). Several studies have established crucial roles for P2 receptors during intestinal inflammatory and infectious diseases, yet the most extensive characterization of purinergic signaling has focused on immu...
Source: Am J Physiol Gastroi... - November 21, 2023 Category: Gastroenterology Authors: Kristen A Engevik Francesca J Scribano J Thomas Gebert Jacob L Perry Sue E Crawford Joseph M Hyser Source Type: research
Characterization of neuromuscular transmission and projections of muscle motor neurons in the rat stomach
In this study, we recorded neuromuscular transmission to the circular muscle using intracellular microelectrodes to investigate the spread of influence of intrinsic motor neurons. In addition, microanatomical investigations of neuronal projections and pharmacological analysis were conducted to investigate neuromuscular relationships. We found that inhibitory neurotransmission to the circular muscle is graded with stimulus strength and circumferential distance from the stimulation site. The influence of inhibitory neurons declined between 1 and 11 mm from the stimulation site. In the antrum, corpus and fundus the declines a...
Source: Am J Physiol Gastroi... - November 21, 2023 Category: Gastroenterology Authors: Madeleine R Di Natale Billie Hunne Martin J Stebbing Xiaokai Wang Zhongming Liu John B Furness Source Type: research
< em > Propionibacterium freudenreichii < /em > CIRM-BIA 129 mitigates colitis through S layer protein B-dependent epithelial strengthening
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 21. doi: 10.1152/ajpgi.00198.2023. Online ahead of print.ABSTRACTThe growing incidence of human diseases involving inflammation and increased gut permeability makes the quest for protective functional foods more crucial than ever. Propionibacterium freudenreichii (Pf) is a beneficial bacterium used in the dairy and probiotic industries. Selected strains exert anti-inflammatory effects, and the present work addresses whether the Pf CIRM-BIA129, consumed daily in a preventive way, could protect mice from acute colitis induced by dextran sodium sulfate (DSS), and more precisel...
Source: Am J Physiol Gastroi... - November 21, 2023 Category: Gastroenterology Authors: Marine Mantel Tony Durand Anne Bessard S égolène Pernet Julie Beaudeau Juliana Guimaraes-Laguna Marie-Bernadette Maillard Eric Gu édon Michel Neunlist Yves Le-Loir Gwena ël Jan Malvyne Rolli-Derkinderen Source Type: research
The distribution of purinergic receptors, P2Y and P2X, expression within the intestine
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 21. doi: 10.1152/ajpgi.00108.2023. Online ahead of print.ABSTRACTNucleotides are potent extracellular signaling molecules during homeostasis, infection, and injury due to their ability to activate purinergic receptors. The nucleotide ATP activates P2X receptors (P2RXs), while the nucleotides ADP, ATP, UTP and UDP-glucose selectively activate different P2Y receptors (P2RYs). Several studies have established crucial roles for P2 receptors during intestinal inflammatory and infectious diseases, yet the most extensive characterization of purinergic signaling has focused on immu...
Source: Am J Physiol Gastroi... - November 21, 2023 Category: Gastroenterology Authors: Kristen A Engevik Francesca J Scribano J Thomas Gebert Jacob L Perry Sue E Crawford Joseph M Hyser Source Type: research
Characterization of neuromuscular transmission and projections of muscle motor neurons in the rat stomach
In this study, we recorded neuromuscular transmission to the circular muscle using intracellular microelectrodes to investigate the spread of influence of intrinsic motor neurons. In addition, microanatomical investigations of neuronal projections and pharmacological analysis were conducted to investigate neuromuscular relationships. We found that inhibitory neurotransmission to the circular muscle is graded with stimulus strength and circumferential distance from the stimulation site. The influence of inhibitory neurons declined between 1 and 11 mm from the stimulation site. In the antrum, corpus and fundus the declines a...
Source: Am J Physiol Gastroi... - November 21, 2023 Category: Gastroenterology Authors: Madeleine R Di Natale Billie Hunne Martin J Stebbing Xiaokai Wang Zhongming Liu John B Furness Source Type: research
< em > Propionibacterium freudenreichii < /em > CIRM-BIA 129 mitigates colitis through S layer protein B-dependent epithelial strengthening
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 21. doi: 10.1152/ajpgi.00198.2023. Online ahead of print.ABSTRACTThe growing incidence of human diseases involving inflammation and increased gut permeability makes the quest for protective functional foods more crucial than ever. Propionibacterium freudenreichii (Pf) is a beneficial bacterium used in the dairy and probiotic industries. Selected strains exert anti-inflammatory effects, and the present work addresses whether the Pf CIRM-BIA129, consumed daily in a preventive way, could protect mice from acute colitis induced by dextran sodium sulfate (DSS), and more precisel...
Source: Am J Physiol Gastroi... - November 21, 2023 Category: Gastroenterology Authors: Marine Mantel Tony Durand Anne Bessard S égolène Pernet Julie Beaudeau Juliana Guimaraes-Laguna Marie-Bernadette Maillard Eric Gu édon Michel Neunlist Yves Le-Loir Gwena ël Jan Malvyne Rolli-Derkinderen Source Type: research
The distribution of purinergic receptors, P2Y and P2X, expression within the intestine
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 21. doi: 10.1152/ajpgi.00108.2023. Online ahead of print.ABSTRACTNucleotides are potent extracellular signaling molecules during homeostasis, infection, and injury due to their ability to activate purinergic receptors. The nucleotide ATP activates P2X receptors (P2RXs), while the nucleotides ADP, ATP, UTP and UDP-glucose selectively activate different P2Y receptors (P2RYs). Several studies have established crucial roles for P2 receptors during intestinal inflammatory and infectious diseases, yet the most extensive characterization of purinergic signaling has focused on immu...
Source: Am J Physiol Gastroi... - November 21, 2023 Category: Gastroenterology Authors: Kristen A Engevik Francesca J Scribano J Thomas Gebert Jacob L Perry Sue E Crawford Joseph M Hyser Source Type: research
Characterization of neuromuscular transmission and projections of muscle motor neurons in the rat stomach
In this study, we recorded neuromuscular transmission to the circular muscle using intracellular microelectrodes to investigate the spread of influence of intrinsic motor neurons. In addition, microanatomical investigations of neuronal projections and pharmacological analysis were conducted to investigate neuromuscular relationships. We found that inhibitory neurotransmission to the circular muscle is graded with stimulus strength and circumferential distance from the stimulation site. The influence of inhibitory neurons declined between 1 and 11 mm from the stimulation site. In the antrum, corpus and fundus the declines a...
Source: Am J Physiol Gastroi... - November 21, 2023 Category: Gastroenterology Authors: Madeleine R Di Natale Billie Hunne Martin J Stebbing Xiaokai Wang Zhongming Liu John B Furness Source Type: research
< em > Propionibacterium freudenreichii < /em > CIRM-BIA 129 mitigates colitis through S layer protein B-dependent epithelial strengthening
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 21. doi: 10.1152/ajpgi.00198.2023. Online ahead of print.ABSTRACTThe growing incidence of human diseases involving inflammation and increased gut permeability makes the quest for protective functional foods more crucial than ever. Propionibacterium freudenreichii (Pf) is a beneficial bacterium used in the dairy and probiotic industries. Selected strains exert anti-inflammatory effects, and the present work addresses whether the Pf CIRM-BIA129, consumed daily in a preventive way, could protect mice from acute colitis induced by dextran sodium sulfate (DSS), and more precisel...
Source: Am J Physiol Gastroi... - November 21, 2023 Category: Gastroenterology Authors: Marine Mantel Tony Durand Anne Bessard S égolène Pernet Julie Beaudeau Juliana Guimaraes-Laguna Marie-Bernadette Maillard Eric Gu édon Michel Neunlist Yves Le-Loir Gwena ël Jan Malvyne Rolli-Derkinderen Source Type: research
The distribution of purinergic receptors, P2Y and P2X, expression within the intestine
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 21. doi: 10.1152/ajpgi.00108.2023. Online ahead of print.ABSTRACTNucleotides are potent extracellular signaling molecules during homeostasis, infection, and injury due to their ability to activate purinergic receptors. The nucleotide ATP activates P2X receptors (P2RXs), while the nucleotides ADP, ATP, UTP and UDP-glucose selectively activate different P2Y receptors (P2RYs). Several studies have established crucial roles for P2 receptors during intestinal inflammatory and infectious diseases, yet the most extensive characterization of purinergic signaling has focused on immu...
Source: Am J Physiol Gastroi... - November 21, 2023 Category: Gastroenterology Authors: Kristen A Engevik Francesca J Scribano J Thomas Gebert Jacob L Perry Sue E Crawford Joseph M Hyser Source Type: research
Characterization of neuromuscular transmission and projections of muscle motor neurons in the rat stomach
In this study, we recorded neuromuscular transmission to the circular muscle using intracellular microelectrodes to investigate the spread of influence of intrinsic motor neurons. In addition, microanatomical investigations of neuronal projections and pharmacological analysis were conducted to investigate neuromuscular relationships. We found that inhibitory neurotransmission to the circular muscle is graded with stimulus strength and circumferential distance from the stimulation site. The influence of inhibitory neurons declined between 1 and 11 mm from the stimulation site. In the antrum, corpus and fundus the declines a...
Source: Am J Physiol Gastroi... - November 21, 2023 Category: Gastroenterology Authors: Madeleine R Di Natale Billie Hunne Martin J Stebbing Xiaokai Wang Zhongming Liu John B Furness Source Type: research
< em > Propionibacterium freudenreichii < /em > CIRM-BIA 129 mitigates colitis through S layer protein B-dependent epithelial strengthening
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 21. doi: 10.1152/ajpgi.00198.2023. Online ahead of print.ABSTRACTThe growing incidence of human diseases involving inflammation and increased gut permeability makes the quest for protective functional foods more crucial than ever. Propionibacterium freudenreichii (Pf) is a beneficial bacterium used in the dairy and probiotic industries. Selected strains exert anti-inflammatory effects, and the present work addresses whether the Pf CIRM-BIA129, consumed daily in a preventive way, could protect mice from acute colitis induced by dextran sodium sulfate (DSS), and more precisel...
Source: Am J Physiol Gastroi... - November 21, 2023 Category: Gastroenterology Authors: Marine Mantel Tony Durand Anne Bessard S égolène Pernet Julie Beaudeau Juliana Guimaraes-Laguna Marie-Bernadette Maillard Eric Gu édon Michel Neunlist Yves Le-Loir Gwena ël Jan Malvyne Rolli-Derkinderen Source Type: research
The distribution of purinergic receptors, P2Y and P2X, expression within the intestine
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 21. doi: 10.1152/ajpgi.00108.2023. Online ahead of print.ABSTRACTNucleotides are potent extracellular signaling molecules during homeostasis, infection, and injury due to their ability to activate purinergic receptors. The nucleotide ATP activates P2X receptors (P2RXs), while the nucleotides ADP, ATP, UTP and UDP-glucose selectively activate different P2Y receptors (P2RYs). Several studies have established crucial roles for P2 receptors during intestinal inflammatory and infectious diseases, yet the most extensive characterization of purinergic signaling has focused on immu...
Source: Am J Physiol Gastroi... - November 21, 2023 Category: Gastroenterology Authors: Kristen A Engevik Francesca J Scribano J Thomas Gebert Jacob L Perry Sue E Crawford Joseph M Hyser Source Type: research
Characterization of neuromuscular transmission and projections of muscle motor neurons in the rat stomach
In this study, we recorded neuromuscular transmission to the circular muscle using intracellular microelectrodes to investigate the spread of influence of intrinsic motor neurons. In addition, microanatomical investigations of neuronal projections and pharmacological analysis were conducted to investigate neuromuscular relationships. We found that inhibitory neurotransmission to the circular muscle is graded with stimulus strength and circumferential distance from the stimulation site. The influence of inhibitory neurons declined between 1 and 11 mm from the stimulation site. In the antrum, corpus and fundus the declines a...
Source: Am J Physiol Gastroi... - November 21, 2023 Category: Gastroenterology Authors: Madeleine R Di Natale Billie Hunne Martin J Stebbing Xiaokai Wang Zhongming Liu John B Furness Source Type: research
< em > Propionibacterium freudenreichii < /em > CIRM-BIA 129 mitigates colitis through S layer protein B-dependent epithelial strengthening
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 21. doi: 10.1152/ajpgi.00198.2023. Online ahead of print.ABSTRACTThe growing incidence of human diseases involving inflammation and increased gut permeability makes the quest for protective functional foods more crucial than ever. Propionibacterium freudenreichii (Pf) is a beneficial bacterium used in the dairy and probiotic industries. Selected strains exert anti-inflammatory effects, and the present work addresses whether the Pf CIRM-BIA129, consumed daily in a preventive way, could protect mice from acute colitis induced by dextran sodium sulfate (DSS), and more precisel...
Source: Am J Physiol Gastroi... - November 21, 2023 Category: Gastroenterology Authors: Marine Mantel Tony Durand Anne Bessard S égolène Pernet Julie Beaudeau Juliana Guimaraes-Laguna Marie-Bernadette Maillard Eric Gu édon Michel Neunlist Yves Le-Loir Gwena ël Jan Malvyne Rolli-Derkinderen Source Type: research
