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Key Challenges for < em > In Vitro < /em > Testing of Tobacco Products for Regulatory Applications: Recommendations for the < em > In Vitro < /em > Mouse Lymphoma Assay
This report was developed by a working group composed of attendees of the seventh IIVS workshop, 'Approaches and recommendations for conducting the mouse lymphoma gene mutation assay (MLA) and introduction to in vitro disease models', which was held virtually on 21-23 June 2022. This publication provides a background overview of the MLA, and includes the description of assay conduct and data interpretation, key challenges and recommended best practices for evaluating tobacco and nicotine products, with a focus on the evaluation of NGPs, and a summary of how the assay has been used to evaluate and compare tobacco and nicoti...
Source: Alternatives to Laboratory Animals : ATLA - December 6, 2023 Category: Research Authors: Ian Crooks Julie Clements Rodger Curren Xiaoqing Guo Michael Hollings Mel Lloyd Daniel Smart David Thorne Elisabeth Weber Martha Moore Source Type: research

Spotlight on Three Rs Progress
Altern Lab Anim. 2023 Dec 5:2611929231218600. doi: 10.1177/02611929231218600. Online ahead of print.NO ABSTRACTPMID:38053234 | DOI:10.1177/02611929231218600 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - December 6, 2023 Category: Research Source Type: research

Conference Diary
Altern Lab Anim. 2023 Nov 26:2611929231218598. doi: 10.1177/02611929231218598. Online ahead of print.NO ABSTRACTPMID:38008997 | DOI:10.1177/02611929231218598 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - November 27, 2023 Category: Research Source Type: research

The Numbers of Animals Used in Mexico for Scientific and Educational Purposes
Altern Lab Anim. 2023 Nov 25:2611929231217033. doi: 10.1177/02611929231217033. Online ahead of print.ABSTRACTIn Mexico, there are no official public and reliably reported data on the total number and species of non-human animals used for scientific purposes. The aim of the current study was to calculate the total numbers of animals used for scientific and educational purposes in Mexico, from January 2015 to October 2021, based on data requested from the National Institute of Transparency, Access to Information and Protection of Personal Data (INAI, in Spanish). In this period, authorised laboratory animal facilities report...
Source: Alternatives to Laboratory Animals : ATLA - November 25, 2023 Category: Research Authors: Patricia Fr ías-Álvarez Gustavo Ortiz-Mill án Source Type: research

Conference Diary
Altern Lab Anim. 2023 Nov;51(6):411. doi: 10.1177/02611929231206952. Epub 2023 Oct 25.NO ABSTRACTPMID:37878580 | DOI:10.1177/02611929231206952 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - October 25, 2023 Category: Research Source Type: research