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The Accomplishments of KoCVAM in the Development and Implementation of Alternative Methods in Korea
Altern Lab Anim. 2024 Apr 16:2611929241244520. doi: 10.1177/02611929241244520. Online ahead of print.ABSTRACTThe Korean Center for the Validation of Alternative Methods (KoCVAM), which promotes the Three Rs principles and the use of alternative methods in Korea, has been operating within the Toxicological Screening and Testing Division of the Ministry of Food and Drug Safety (MFDS) since 2009. KoCVAM has exchanged opinions and information on the development and validation of non-animal alternative test methods as part of the International Cooperation on Alternative Test Methods (ICATM), and provided input into draft OECD T...
Source: Alternatives to Laboratory Animals : ATLA - April 16, 2024 Category: Research Authors: Nam-Hee Kang JaeHo Oh Source Type: research

Editorial
Altern Lab Anim. 2024 Apr 15:2611929241246891. doi: 10.1177/02611929241246891. Online ahead of print.NO ABSTRACTPMID:38622052 | DOI:10.1177/02611929241246891 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - April 15, 2024 Category: Research Authors: Judith C Madden Source Type: research

Spotlight on Three Rs Progress
Altern Lab Anim. 2024 Apr 13:2611929241245507. doi: 10.1177/02611929241245507. Online ahead of print.NO ABSTRACTPMID:38613318 | DOI:10.1177/02611929241245507 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - April 13, 2024 Category: Research Source Type: research

Resources Round-up
Altern Lab Anim. 2024 Apr 13:2611929241245521. doi: 10.1177/02611929241245521. Online ahead of print.NO ABSTRACTPMID:38613323 | DOI:10.1177/02611929241245521 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - April 13, 2024 Category: Research Source Type: research

A Novel < em > Ex Vivo < /em > Blinking Method for Comparing the Corneal Residence Time of New Shampoo Formulations
In this study, we developed a system that simulates corneal exposure to blinking and tear flow, for comparing the corneal clearance times of viscous detergent formulations. The Ex Vivo Eye Irritation Test (EVEIT), which uses corneal explants from discarded rabbit eyes from an abattoir, was used as the basis for the new system. To simulate blinking, we developed a silicone wiping membrane to regularly move across the corneal surface, under conditions of constant addition and aspiration of fluid, to mimic tear flow. Six shampoo formulations were tested and were shown to differ widely in their corneal clearance time. Three gr...
Source: Alternatives to Laboratory Animals : ATLA - April 12, 2024 Category: Research Authors: Markus Glaudo Marc Urbach Claudia Panfil Stephanie Herkert Mark Brown Norbert Schrage Source Type: research

Conference Diary
Altern Lab Anim. 2024 Apr 9:2611929241245506. doi: 10.1177/02611929241245506. Online ahead of print.NO ABSTRACTPMID:38594898 | DOI:10.1177/02611929241245506 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - April 10, 2024 Category: Research Source Type: research

Acute Toxicity Assays with the < em > Artemia salina < /em > Model: Assessment of Variables
Altern Lab Anim. 2024 Apr 5:2611929241242443. doi: 10.1177/02611929241242443. Online ahead of print.ABSTRACTThe use of the brine shrimp Artemia salina (Leach) in acute toxicity assays has great potential due to its simplicity, low cost and reproducibility. In the current study, some of the variables that can influence the reliability of the assay in terms of test organism survival, were evaluated as part of its implementation in our laboratory. The quality and type of water used, the buffer components and other parameters (salinity, pH and dissolved oxygen level), were all evaluated for optimisation purposes. DMSO (dimethy...
Source: Alternatives to Laboratory Animals : ATLA - April 5, 2024 Category: Research Authors: Gerson Salay N ádila Lucarelli Tha ís Moura Gascón Samantha Sanches de Carvalho Glaucia Raquel Luciano da Veiga Beatriz da Costa Aguiar Alves Reis Fernando Luiz Affonso Fonseca Source Type: research