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Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids
In this study, a drug-resistant 3-D tumour spheroid model was developed, based on sorafenib-resistant hepatocellular carcinoma cells, LX2 stellate cells and THP-1 monocytes. Model tumour spheroids that were formed with the sorafenib-resistant cells demonstrated lower diffusion of doxorubicin and exhibited increased resistance to regorafenib. Moreover, in the sorafenib-resistant spheroids, there was increased presence of CD68-positive cells and a reduction in inflammatory marker secretion. The sorafenib-resistant cell line-derived spheroids also showed a higher expression of FGF-19, PDGF-AA and GDF-15, which are known to be...
Source: Alternatives to Laboratory Animals : ATLA - August 9, 2023 Category: Research Authors: Ece Sariyar Zeynep Firtina Karagonlar Source Type: research

Evaluating the Impact of Hair Care Product Exposure on Hair Follicle and Scalp Health
Altern Lab Anim. 2023 Aug 9:2611929231190863. doi: 10.1177/02611929231190863. Online ahead of print.ABSTRACTHuman hair follicles traverse the epidermis and dermis, and are comprised of specialised cells including dermal papilla cells (DPCs). DPCs play a critical role in the development and growth of both hair and follicle structure. While exposure of DPCs to undiluted exogenous compounds is unlikely, exposure to diluted compounds is possible should dermal penetration occur. The goal of this study was to evaluate the impact on hair and scalp health following application of a hair care product. Due to the lack of standardise...
Source: Alternatives to Laboratory Animals : ATLA - August 9, 2023 Category: Research Authors: Ernest S Fung Jillian A Parker Andrew D Monnot Source Type: research

Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids
In this study, a drug-resistant 3-D tumour spheroid model was developed, based on sorafenib-resistant hepatocellular carcinoma cells, LX2 stellate cells and THP-1 monocytes. Model tumour spheroids that were formed with the sorafenib-resistant cells demonstrated lower diffusion of doxorubicin and exhibited increased resistance to regorafenib. Moreover, in the sorafenib-resistant spheroids, there was increased presence of CD68-positive cells and a reduction in inflammatory marker secretion. The sorafenib-resistant cell line-derived spheroids also showed a higher expression of FGF-19, PDGF-AA and GDF-15, which are known to be...
Source: Alternatives to Laboratory Animals : ATLA - August 9, 2023 Category: Research Authors: Ece Sariyar Zeynep Firtina Karagonlar Source Type: research

Evaluating the Impact of Hair Care Product Exposure on Hair Follicle and Scalp Health
Altern Lab Anim. 2023 Aug 9:2611929231190863. doi: 10.1177/02611929231190863. Online ahead of print.ABSTRACTHuman hair follicles traverse the epidermis and dermis, and are comprised of specialised cells including dermal papilla cells (DPCs). DPCs play a critical role in the development and growth of both hair and follicle structure. While exposure of DPCs to undiluted exogenous compounds is unlikely, exposure to diluted compounds is possible should dermal penetration occur. The goal of this study was to evaluate the impact on hair and scalp health following application of a hair care product. Due to the lack of standardise...
Source: Alternatives to Laboratory Animals : ATLA - August 9, 2023 Category: Research Authors: Ernest S Fung Jillian A Parker Andrew D Monnot Source Type: research

Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids
In this study, a drug-resistant 3-D tumour spheroid model was developed, based on sorafenib-resistant hepatocellular carcinoma cells, LX2 stellate cells and THP-1 monocytes. Model tumour spheroids that were formed with the sorafenib-resistant cells demonstrated lower diffusion of doxorubicin and exhibited increased resistance to regorafenib. Moreover, in the sorafenib-resistant spheroids, there was increased presence of CD68-positive cells and a reduction in inflammatory marker secretion. The sorafenib-resistant cell line-derived spheroids also showed a higher expression of FGF-19, PDGF-AA and GDF-15, which are known to be...
Source: Alternatives to Laboratory Animals : ATLA - August 9, 2023 Category: Research Authors: Ece Sariyar Zeynep Firtina Karagonlar Source Type: research

Evaluating the Impact of Hair Care Product Exposure on Hair Follicle and Scalp Health
Altern Lab Anim. 2023 Aug 9:2611929231190863. doi: 10.1177/02611929231190863. Online ahead of print.ABSTRACTHuman hair follicles traverse the epidermis and dermis, and are comprised of specialised cells including dermal papilla cells (DPCs). DPCs play a critical role in the development and growth of both hair and follicle structure. While exposure of DPCs to undiluted exogenous compounds is unlikely, exposure to diluted compounds is possible should dermal penetration occur. The goal of this study was to evaluate the impact on hair and scalp health following application of a hair care product. Due to the lack of standardise...
Source: Alternatives to Laboratory Animals : ATLA - August 9, 2023 Category: Research Authors: Ernest S Fung Jillian A Parker Andrew D Monnot Source Type: research

Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids
In this study, a drug-resistant 3-D tumour spheroid model was developed, based on sorafenib-resistant hepatocellular carcinoma cells, LX2 stellate cells and THP-1 monocytes. Model tumour spheroids that were formed with the sorafenib-resistant cells demonstrated lower diffusion of doxorubicin and exhibited increased resistance to regorafenib. Moreover, in the sorafenib-resistant spheroids, there was increased presence of CD68-positive cells and a reduction in inflammatory marker secretion. The sorafenib-resistant cell line-derived spheroids also showed a higher expression of FGF-19, PDGF-AA and GDF-15, which are known to be...
Source: Alternatives to Laboratory Animals : ATLA - August 9, 2023 Category: Research Authors: Ece Sariyar Zeynep Firtina Karagonlar Source Type: research

Evaluating the Impact of Hair Care Product Exposure on Hair Follicle and Scalp Health
Altern Lab Anim. 2023 Aug 9:2611929231190863. doi: 10.1177/02611929231190863. Online ahead of print.ABSTRACTHuman hair follicles traverse the epidermis and dermis, and are comprised of specialised cells including dermal papilla cells (DPCs). DPCs play a critical role in the development and growth of both hair and follicle structure. While exposure of DPCs to undiluted exogenous compounds is unlikely, exposure to diluted compounds is possible should dermal penetration occur. The goal of this study was to evaluate the impact on hair and scalp health following application of a hair care product. Due to the lack of standardise...
Source: Alternatives to Laboratory Animals : ATLA - August 9, 2023 Category: Research Authors: Ernest S Fung Jillian A Parker Andrew D Monnot Source Type: research

Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids
In this study, a drug-resistant 3-D tumour spheroid model was developed, based on sorafenib-resistant hepatocellular carcinoma cells, LX2 stellate cells and THP-1 monocytes. Model tumour spheroids that were formed with the sorafenib-resistant cells demonstrated lower diffusion of doxorubicin and exhibited increased resistance to regorafenib. Moreover, in the sorafenib-resistant spheroids, there was increased presence of CD68-positive cells and a reduction in inflammatory marker secretion. The sorafenib-resistant cell line-derived spheroids also showed a higher expression of FGF-19, PDGF-AA and GDF-15, which are known to be...
Source: Alternatives to Laboratory Animals : ATLA - August 9, 2023 Category: Research Authors: Ece Sariyar Zeynep Firtina Karagonlar Source Type: research

Evaluating the Impact of Hair Care Product Exposure on Hair Follicle and Scalp Health
Altern Lab Anim. 2023 Aug 9:2611929231190863. doi: 10.1177/02611929231190863. Online ahead of print.ABSTRACTHuman hair follicles traverse the epidermis and dermis, and are comprised of specialised cells including dermal papilla cells (DPCs). DPCs play a critical role in the development and growth of both hair and follicle structure. While exposure of DPCs to undiluted exogenous compounds is unlikely, exposure to diluted compounds is possible should dermal penetration occur. The goal of this study was to evaluate the impact on hair and scalp health following application of a hair care product. Due to the lack of standardise...
Source: Alternatives to Laboratory Animals : ATLA - August 9, 2023 Category: Research Authors: Ernest S Fung Jillian A Parker Andrew D Monnot Source Type: research

Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids
In this study, a drug-resistant 3-D tumour spheroid model was developed, based on sorafenib-resistant hepatocellular carcinoma cells, LX2 stellate cells and THP-1 monocytes. Model tumour spheroids that were formed with the sorafenib-resistant cells demonstrated lower diffusion of doxorubicin and exhibited increased resistance to regorafenib. Moreover, in the sorafenib-resistant spheroids, there was increased presence of CD68-positive cells and a reduction in inflammatory marker secretion. The sorafenib-resistant cell line-derived spheroids also showed a higher expression of FGF-19, PDGF-AA and GDF-15, which are known to be...
Source: Alternatives to Laboratory Animals : ATLA - August 9, 2023 Category: Research Authors: Ece Sariyar Zeynep Firtina Karagonlar Source Type: research

Evaluating the Impact of Hair Care Product Exposure on Hair Follicle and Scalp Health
Altern Lab Anim. 2023 Aug 9:2611929231190863. doi: 10.1177/02611929231190863. Online ahead of print.ABSTRACTHuman hair follicles traverse the epidermis and dermis, and are comprised of specialised cells including dermal papilla cells (DPCs). DPCs play a critical role in the development and growth of both hair and follicle structure. While exposure of DPCs to undiluted exogenous compounds is unlikely, exposure to diluted compounds is possible should dermal penetration occur. The goal of this study was to evaluate the impact on hair and scalp health following application of a hair care product. Due to the lack of standardise...
Source: Alternatives to Laboratory Animals : ATLA - August 9, 2023 Category: Research Authors: Ernest S Fung Jillian A Parker Andrew D Monnot Source Type: research

Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids
In this study, a drug-resistant 3-D tumour spheroid model was developed, based on sorafenib-resistant hepatocellular carcinoma cells, LX2 stellate cells and THP-1 monocytes. Model tumour spheroids that were formed with the sorafenib-resistant cells demonstrated lower diffusion of doxorubicin and exhibited increased resistance to regorafenib. Moreover, in the sorafenib-resistant spheroids, there was increased presence of CD68-positive cells and a reduction in inflammatory marker secretion. The sorafenib-resistant cell line-derived spheroids also showed a higher expression of FGF-19, PDGF-AA and GDF-15, which are known to be...
Source: Alternatives to Laboratory Animals : ATLA - August 9, 2023 Category: Research Authors: Ece Sariyar Zeynep Firtina Karagonlar Source Type: research

Evaluating the Impact of Hair Care Product Exposure on Hair Follicle and Scalp Health
Altern Lab Anim. 2023 Aug 9:2611929231190863. doi: 10.1177/02611929231190863. Online ahead of print.ABSTRACTHuman hair follicles traverse the epidermis and dermis, and are comprised of specialised cells including dermal papilla cells (DPCs). DPCs play a critical role in the development and growth of both hair and follicle structure. While exposure of DPCs to undiluted exogenous compounds is unlikely, exposure to diluted compounds is possible should dermal penetration occur. The goal of this study was to evaluate the impact on hair and scalp health following application of a hair care product. Due to the lack of standardise...
Source: Alternatives to Laboratory Animals : ATLA - August 9, 2023 Category: Research Authors: Ernest S Fung Jillian A Parker Andrew D Monnot Source Type: research

Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids
In this study, a drug-resistant 3-D tumour spheroid model was developed, based on sorafenib-resistant hepatocellular carcinoma cells, LX2 stellate cells and THP-1 monocytes. Model tumour spheroids that were formed with the sorafenib-resistant cells demonstrated lower diffusion of doxorubicin and exhibited increased resistance to regorafenib. Moreover, in the sorafenib-resistant spheroids, there was increased presence of CD68-positive cells and a reduction in inflammatory marker secretion. The sorafenib-resistant cell line-derived spheroids also showed a higher expression of FGF-19, PDGF-AA and GDF-15, which are known to be...
Source: Alternatives to Laboratory Animals : ATLA - August 9, 2023 Category: Research Authors: Ece Sariyar Zeynep Firtina Karagonlar Source Type: research