Alternatives to Laboratory Animals : ATLA 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.A Human Cell-based Assay to Assess the Induction of Vasculature Formation for Non-genotoxic Carcinogenicity Testing Purposes: A Pilot Study
Altern Lab Anim. 2023 Apr 26:2611929231171165. doi: 10.1177/02611929231171165. Online ahead of print.ABSTRACTThe induction of vasculature formation is proposed to be a significant mechanism behind the non-genotoxic carcinogenicity of a chemical. The vasculature formation model used in this study is based on the coculture of human primary HUVECs and hASCs. This model was used to develop an assay to assess the induction of vasculature formation. Three assay protocols, based on different conditions, were developed and compared in order to identify the optimal conditions required. Some serum supplements and growth factors were...
Source: Alternatives to Laboratory Animals : ATLA - May 1, 2023 Category: Research Authors: Veera Hautanen Tarja Toimela Martin Paparella Tuula Heinonen Source Type: research
A Human Cell-based Assay to Assess the Induction of Vasculature Formation for Non-genotoxic Carcinogenicity Testing Purposes: A Pilot Study
Altern Lab Anim. 2023 Apr 26:2611929231171165. doi: 10.1177/02611929231171165. Online ahead of print.ABSTRACTThe induction of vasculature formation is proposed to be a significant mechanism behind the non-genotoxic carcinogenicity of a chemical. The vasculature formation model used in this study is based on the coculture of human primary HUVECs and hASCs. This model was used to develop an assay to assess the induction of vasculature formation. Three assay protocols, based on different conditions, were developed and compared in order to identify the optimal conditions required. Some serum supplements and growth factors were...
Source: Alternatives to Laboratory Animals : ATLA - May 1, 2023 Category: Research Authors: Veera Hautanen Tarja Toimela Martin Paparella Tuula Heinonen Source Type: research
A Human Cell-based Assay to Assess the Induction of Vasculature Formation for Non-genotoxic Carcinogenicity Testing Purposes: A Pilot Study
Altern Lab Anim. 2023 Apr 26:2611929231171165. doi: 10.1177/02611929231171165. Online ahead of print.ABSTRACTThe induction of vasculature formation is proposed to be a significant mechanism behind the non-genotoxic carcinogenicity of a chemical. The vasculature formation model used in this study is based on the coculture of human primary HUVECs and hASCs. This model was used to develop an assay to assess the induction of vasculature formation. Three assay protocols, based on different conditions, were developed and compared in order to identify the optimal conditions required. Some serum supplements and growth factors were...
Source: Alternatives to Laboratory Animals : ATLA - May 1, 2023 Category: Research Authors: Veera Hautanen Tarja Toimela Martin Paparella Tuula Heinonen Source Type: research
Use of the < em > Allium cepa < /em > Model to Assess the Cytogenotoxicity of < em > Luffariella herdmani < /em > Marine Sponge Extract
Altern Lab Anim. 2023 Apr 26:2611929231171943. doi: 10.1177/02611929231171943. Online ahead of print.ABSTRACTMarine sponge extracts are known to contain potentially toxic compounds that have biological activities of possible pharmacological interest. Thus, it is vital that biological models are used for the preliminary toxicity screening of such extracts. The present study reports the use of Allium cepa, a low-cost plant-based in vivo model, to assess the cytotoxicity and genotoxicity of Luffariella herdmani marine sponge crude extract (SCE). Pre-germinated onion bulbs, exposed for 96 hours to different concentrations of S...
Source: Alternatives to Laboratory Animals : ATLA - April 26, 2023 Category: Research Authors: Sashini U Kuruppuarachchi Uthpala A Jayawardena Varuni K Gunathilake Source Type: research
Use of the < em > Allium cepa < /em > Model to Assess the Cytogenotoxicity of < em > Luffariella herdmani < /em > Marine Sponge Extract
Altern Lab Anim. 2023 Apr 26:2611929231171943. doi: 10.1177/02611929231171943. Online ahead of print.ABSTRACTMarine sponge extracts are known to contain potentially toxic compounds that have biological activities of possible pharmacological interest. Thus, it is vital that biological models are used for the preliminary toxicity screening of such extracts. The present study reports the use of Allium cepa, a low-cost plant-based in vivo model, to assess the cytotoxicity and genotoxicity of Luffariella herdmani marine sponge crude extract (SCE). Pre-germinated onion bulbs, exposed for 96 hours to different concentrations of S...
Source: Alternatives to Laboratory Animals : ATLA - April 26, 2023 Category: Research Authors: Sashini U Kuruppuarachchi Uthpala A Jayawardena Varuni K Gunathilake Source Type: research
