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Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against < em > Mycobacterium tuberculosis < /em >
This study also aimed to predict LD50 values of potential drug candidates that would be active against the standard H37Rv strain of M. tuberculosis, by using the ProTox-II in silico tool. The molecules for which no structural hazard alerts were identified with these software tools were further subjected to molecular docking analyses and molecular dynamic simulations to estimate their ability to interact with the MtSK enzyme. Preliminary results from SwissADME indicated that 30 molecules were drug-like, due to their physicochemical and pharmacokinetic properties. However, subsequent analysis with ToxTree and ProTox-II indic...
Source: Alternatives to Laboratory Animals : ATLA - December 14, 2023 Category: Research Authors: Ashish Jhangiani Vandana Panda Aanchal Sukheja Sneha Thomas Piyush Dusseja Siddhartha Pandya Anand Chintakrindi Source Type: research

Resources Round-up
Altern Lab Anim. 2023 Dec 11:2611929231218599. doi: 10.1177/02611929231218599. Online ahead of print.NO ABSTRACTPMID:38078909 | DOI:10.1177/02611929231218599 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - December 11, 2023 Category: Research Source Type: research

Editorial
Altern Lab Anim. 2023 Dec 8:2611929231220133. doi: 10.1177/02611929231220133. Online ahead of print.NO ABSTRACTPMID:38063478 | DOI:10.1177/02611929231220133 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - December 8, 2023 Category: Research Authors: Judith C Madden Source Type: research

Brazilian National Network of Alternative Methods (RENAMA) 10th Anniversary: Meeting of the Associated Laboratories, May 2022
Altern Lab Anim. 2023 Dec 7:2611929231218378. doi: 10.1177/02611929231218378. Online ahead of print.ABSTRACTThe Brazilian National Network of Alternative Methods (RENAMA), which is linked to the Ministry of Science, Technology and Innovation, is currently comprised of 51 laboratories from CROs, academia, industry and government. RENAMA's aim is to develop and validate new approach methodologies (NAMs), as well as train researchers and disseminate information on their use - thus reducing Brazilian, and consequently Latin American, dependence on external technology. Moreover, it promotes the adoption of NAMs by educators and...
Source: Alternatives to Laboratory Animals : ATLA - December 7, 2023 Category: Research Authors: Renato Ivan de Ávila Julia Fentem Izabel Villela Debora Somlo Ana Marisa Fusco Almeida Maria Jos é S Mendes-Giannini Andrezza Di Pietro Micali Canavez Bruna Bosquetti Carolina Motter Catarino Desiree Cigaran Schuck Bruna Nardy Valadares Gustavo Facchini Source Type: research

Spotlight on Three Rs Progress
Altern Lab Anim. 2023 Dec 5:2611929231218600. doi: 10.1177/02611929231218600. Online ahead of print.NO ABSTRACTPMID:38053234 | DOI:10.1177/02611929231218600 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - December 6, 2023 Category: Research Source Type: research