Spotlight on Three Rs Progress
Altern Lab Anim. 2024 Feb 20:2611929241232216. doi: 10.1177/02611929241232216. Online ahead of print.NO ABSTRACTPMID:38375565 | DOI:10.1177/02611929241232216 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - February 20, 2024 Category: Research Source Type: research

Spotlight on Three Rs Progress
Altern Lab Anim. 2024 Feb 20:2611929241232216. doi: 10.1177/02611929241232216. Online ahead of print.NO ABSTRACTPMID:38375565 | DOI:10.1177/02611929241232216 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - February 20, 2024 Category: Research Source Type: research

Spotlight on Three Rs Progress
Altern Lab Anim. 2024 Feb 20:2611929241232216. doi: 10.1177/02611929241232216. Online ahead of print.NO ABSTRACTPMID:38375565 | DOI:10.1177/02611929241232216 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - February 20, 2024 Category: Research Source Type: research

Spotlight on Three Rs Progress
Altern Lab Anim. 2024 Feb 20:2611929241232216. doi: 10.1177/02611929241232216. Online ahead of print.NO ABSTRACTPMID:38375565 | DOI:10.1177/02611929241232216 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - February 20, 2024 Category: Research Source Type: research

Spotlight on Three Rs Progress
Altern Lab Anim. 2024 Feb 20:2611929241232216. doi: 10.1177/02611929241232216. Online ahead of print.NO ABSTRACTPMID:38375565 | DOI:10.1177/02611929241232216 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - February 20, 2024 Category: Research Source Type: research

Spotlight on Three Rs Progress
Altern Lab Anim. 2024 Feb 20:2611929241232216. doi: 10.1177/02611929241232216. Online ahead of print.NO ABSTRACTPMID:38375565 | DOI:10.1177/02611929241232216 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - February 20, 2024 Category: Research Source Type: research

Spotlight on Three Rs Progress
Altern Lab Anim. 2024 Feb 20:2611929241232216. doi: 10.1177/02611929241232216. Online ahead of print.NO ABSTRACTPMID:38375565 | DOI:10.1177/02611929241232216 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - February 20, 2024 Category: Research Source Type: research

Spotlight on Three Rs Progress
Altern Lab Anim. 2024 Feb 20:2611929241232216. doi: 10.1177/02611929241232216. Online ahead of print.NO ABSTRACTPMID:38375565 | DOI:10.1177/02611929241232216 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - February 20, 2024 Category: Research Source Type: research

Spotlight on Three Rs Progress
Altern Lab Anim. 2024 Feb 20:2611929241232216. doi: 10.1177/02611929241232216. Online ahead of print.NO ABSTRACTPMID:38375565 | DOI:10.1177/02611929241232216 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - February 20, 2024 Category: Research Source Type: research

Spotlight on Three Rs Progress
Altern Lab Anim. 2024 Feb 20:2611929241232216. doi: 10.1177/02611929241232216. Online ahead of print.NO ABSTRACTPMID:38375565 | DOI:10.1177/02611929241232216 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - February 20, 2024 Category: Research Source Type: research

Thanks to Reviewers
Altern Lab Anim. 2024 Feb 15:2611929241234014. doi: 10.1177/02611929241234014. Online ahead of print.NO ABSTRACTPMID:38361346 | DOI:10.1177/02611929241234014 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - February 16, 2024 Category: Research Source Type: research

Chitosan-Calcium Aluminate as a Cell-homing Scaffold: Its Bioactivity Testing in a Microphysiological Dental Pulp Platform
In this study, a scaffold/3-D dental pulp cell culture interface was created in a microchip, under simulated dental pulp pressure, to evaluate the cell-homing potential of a chitosan (CH) scaffold functionalised with calcium aluminate (the 'CHAlCa scaffold'). This microphysiological platform was cultured at a pressure of 15 cm H2O for up to 14 days; cell viability, migration and odontoblastic differentiation were then assessed. The CHAlCa scaffold exhibited intense chemotactic potential, causing cells to migrate from the 3-D culture to its surface, followed by infiltration into the macroporous structure of the scaffold. By...
Source: Alternatives to Laboratory Animals : ATLA - February 14, 2024 Category: Research Authors: Ester Alves Ferreira Bordini Vitor de Toledo Stuani L ígia Espoliar Correa Fernanda Balestrero Cassiano Marcella Fernandes Lovison Maria Luisa Leite Josimeri Hebling Carlos Alberto de Souza Costa Diana Gabriela Soares Source Type: research

Chitosan-Calcium Aluminate as a Cell-homing Scaffold: Its Bioactivity Testing in a Microphysiological Dental Pulp Platform
In this study, a scaffold/3-D dental pulp cell culture interface was created in a microchip, under simulated dental pulp pressure, to evaluate the cell-homing potential of a chitosan (CH) scaffold functionalised with calcium aluminate (the 'CHAlCa scaffold'). This microphysiological platform was cultured at a pressure of 15 cm H2O for up to 14 days; cell viability, migration and odontoblastic differentiation were then assessed. The CHAlCa scaffold exhibited intense chemotactic potential, causing cells to migrate from the 3-D culture to its surface, followed by infiltration into the macroporous structure of the scaffold. By...
Source: Alternatives to Laboratory Animals : ATLA - February 14, 2024 Category: Research Authors: Ester Alves Ferreira Bordini Vitor de Toledo Stuani L ígia Espoliar Correa Fernanda Balestrero Cassiano Marcella Fernandes Lovison Maria Luisa Leite Josimeri Hebling Carlos Alberto de Souza Costa Diana Gabriela Soares Source Type: research

Resources Round-up
Altern Lab Anim. 2024 Feb 13:2611929241232217. doi: 10.1177/02611929241232217. Online ahead of print.NO ABSTRACTPMID:38349950 | DOI:10.1177/02611929241232217 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - February 13, 2024 Category: Research Source Type: research

Conference Diary
Altern Lab Anim. 2024 Feb 13:2611929241232215. doi: 10.1177/02611929241232215. Online ahead of print.NO ABSTRACTPMID:38349954 | DOI:10.1177/02611929241232215 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - February 13, 2024 Category: Research Source Type: research