Development of an < em > In Vitro < /em > Sensitisation Test Using a Coculture System of Human Bronchial Epithelium and Immune Cells
Altern Lab Anim. 2023 Oct 5:2611929231204823. doi: 10.1177/02611929231204823. Online ahead of print.ABSTRACTChemical respiratory sensitisation is a serious health problem. However, to date, there are no validated test methods available for identifying respiratory sensitisers. The aim of this study was to develop an in vitro sensitisation test by modifying the human cell line activation test (h-CLAT) to detect respiratory sensitisers and distinguish them from skin sensitisers. THP-1 cells were exposed to the test chemicals (two skin sensitisers and six respiratory sensitisers), either as monocultures or as cocultures with a...
Source: Alternatives to Laboratory Animals : ATLA - October 5, 2023 Category: Research Authors: Ikuya Tanabe Kunitaka Yoshida Shinkichi Ishikawa Kanae Ishimori Tsuneo Hashizume Takayuki Yoshimoto Takao Ashikaga Source Type: research

Development of an < em > In Vitro < /em > Sensitisation Test Using a Coculture System of Human Bronchial Epithelium and Immune Cells
Altern Lab Anim. 2023 Oct 5:2611929231204823. doi: 10.1177/02611929231204823. Online ahead of print.ABSTRACTChemical respiratory sensitisation is a serious health problem. However, to date, there are no validated test methods available for identifying respiratory sensitisers. The aim of this study was to develop an in vitro sensitisation test by modifying the human cell line activation test (h-CLAT) to detect respiratory sensitisers and distinguish them from skin sensitisers. THP-1 cells were exposed to the test chemicals (two skin sensitisers and six respiratory sensitisers), either as monocultures or as cocultures with a...
Source: Alternatives to Laboratory Animals : ATLA - October 5, 2023 Category: Research Authors: Ikuya Tanabe Kunitaka Yoshida Shinkichi Ishikawa Kanae Ishimori Tsuneo Hashizume Takayuki Yoshimoto Takao Ashikaga Source Type: research

Development of an < em > In Vitro < /em > Sensitisation Test Using a Coculture System of Human Bronchial Epithelium and Immune Cells
Altern Lab Anim. 2023 Oct 5:2611929231204823. doi: 10.1177/02611929231204823. Online ahead of print.ABSTRACTChemical respiratory sensitisation is a serious health problem. However, to date, there are no validated test methods available for identifying respiratory sensitisers. The aim of this study was to develop an in vitro sensitisation test by modifying the human cell line activation test (h-CLAT) to detect respiratory sensitisers and distinguish them from skin sensitisers. THP-1 cells were exposed to the test chemicals (two skin sensitisers and six respiratory sensitisers), either as monocultures or as cocultures with a...
Source: Alternatives to Laboratory Animals : ATLA - October 5, 2023 Category: Research Authors: Ikuya Tanabe Kunitaka Yoshida Shinkichi Ishikawa Kanae Ishimori Tsuneo Hashizume Takayuki Yoshimoto Takao Ashikaga Source Type: research

Development of an < em > In Vitro < /em > Sensitisation Test Using a Coculture System of Human Bronchial Epithelium and Immune Cells
Altern Lab Anim. 2023 Oct 5:2611929231204823. doi: 10.1177/02611929231204823. Online ahead of print.ABSTRACTChemical respiratory sensitisation is a serious health problem. However, to date, there are no validated test methods available for identifying respiratory sensitisers. The aim of this study was to develop an in vitro sensitisation test by modifying the human cell line activation test (h-CLAT) to detect respiratory sensitisers and distinguish them from skin sensitisers. THP-1 cells were exposed to the test chemicals (two skin sensitisers and six respiratory sensitisers), either as monocultures or as cocultures with a...
Source: Alternatives to Laboratory Animals : ATLA - October 5, 2023 Category: Research Authors: Ikuya Tanabe Kunitaka Yoshida Shinkichi Ishikawa Kanae Ishimori Tsuneo Hashizume Takayuki Yoshimoto Takao Ashikaga Source Type: research

Development of an < em > In Vitro < /em > Sensitisation Test Using a Coculture System of Human Bronchial Epithelium and Immune Cells
Altern Lab Anim. 2023 Oct 5:2611929231204823. doi: 10.1177/02611929231204823. Online ahead of print.ABSTRACTChemical respiratory sensitisation is a serious health problem. However, to date, there are no validated test methods available for identifying respiratory sensitisers. The aim of this study was to develop an in vitro sensitisation test by modifying the human cell line activation test (h-CLAT) to detect respiratory sensitisers and distinguish them from skin sensitisers. THP-1 cells were exposed to the test chemicals (two skin sensitisers and six respiratory sensitisers), either as monocultures or as cocultures with a...
Source: Alternatives to Laboratory Animals : ATLA - October 5, 2023 Category: Research Authors: Ikuya Tanabe Kunitaka Yoshida Shinkichi Ishikawa Kanae Ishimori Tsuneo Hashizume Takayuki Yoshimoto Takao Ashikaga Source Type: research

Resources Round-up
Altern Lab Anim. 2023 Sep;51(5):298-300. doi: 10.1177/02611929231200538. Epub 2023 Sep 3.NO ABSTRACTPMID:37661327 | DOI:10.1177/02611929231200538 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - September 4, 2023 Category: Research Source Type: research

Resources Round-up
Altern Lab Anim. 2023 Sep;51(5):298-300. doi: 10.1177/02611929231200538. Epub 2023 Sep 3.NO ABSTRACTPMID:37661327 | DOI:10.1177/02611929231200538 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - September 4, 2023 Category: Research Source Type: research

Resources Round-up
Altern Lab Anim. 2023 Sep;51(5):298-300. doi: 10.1177/02611929231200538. Epub 2023 Sep 3.NO ABSTRACTPMID:37661327 | DOI:10.1177/02611929231200538 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - September 4, 2023 Category: Research Source Type: research

Resources Round-up
Altern Lab Anim. 2023 Sep 3:2611929231200538. doi: 10.1177/02611929231200538. Online ahead of print.NO ABSTRACTPMID:37661327 | DOI:10.1177/02611929231200538 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - September 4, 2023 Category: Research Source Type: research

Resources Round-up
Altern Lab Anim. 2023 Sep 3:2611929231200538. doi: 10.1177/02611929231200538. Online ahead of print.NO ABSTRACTPMID:37661327 | DOI:10.1177/02611929231200538 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - September 4, 2023 Category: Research Source Type: research

Resources Round-up
Altern Lab Anim. 2023 Sep 3:2611929231200538. doi: 10.1177/02611929231200538. Online ahead of print.NO ABSTRACTPMID:37661327 | DOI:10.1177/02611929231200538 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - September 4, 2023 Category: Research Source Type: research

Resources Round-up
Altern Lab Anim. 2023 Sep 3:2611929231200538. doi: 10.1177/02611929231200538. Online ahead of print.NO ABSTRACTPMID:37661327 | DOI:10.1177/02611929231200538 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - September 4, 2023 Category: Research Source Type: research

Resources Round-up
Altern Lab Anim. 2023 Sep 3:2611929231200538. doi: 10.1177/02611929231200538. Online ahead of print.NO ABSTRACTPMID:37661327 | DOI:10.1177/02611929231200538 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - September 4, 2023 Category: Research Source Type: research

Resources Round-up
Altern Lab Anim. 2023 Sep 3:2611929231200538. doi: 10.1177/02611929231200538. Online ahead of print.NO ABSTRACTPMID:37661327 | DOI:10.1177/02611929231200538 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - September 4, 2023 Category: Research Source Type: research

Resources Round-up
Altern Lab Anim. 2023 Sep 3:2611929231200538. doi: 10.1177/02611929231200538. Online ahead of print.NO ABSTRACTPMID:37661327 | DOI:10.1177/02611929231200538 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - September 4, 2023 Category: Research Source Type: research