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Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against < em > Mycobacterium tuberculosis < /em >
This study also aimed to predict LD50 values of potential drug candidates that would be active against the standard H37Rv strain of M. tuberculosis, by using the ProTox-II in silico tool. The molecules for which no structural hazard alerts were identified with these software tools were further subjected to molecular docking analyses and molecular dynamic simulations to estimate their ability to interact with the MtSK enzyme. Preliminary results from SwissADME indicated that 30 molecules were drug-like, due to their physicochemical and pharmacokinetic properties. However, subsequent analysis with ToxTree and ProTox-II indic...
Source: Alternatives to Laboratory Animals : ATLA - December 14, 2023 Category: Research Authors: Ashish Jhangiani Vandana Panda Aanchal Sukheja Sneha Thomas Piyush Dusseja Siddhartha Pandya Anand Chintakrindi Source Type: research

Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against < em > Mycobacterium tuberculosis < /em >
This study also aimed to predict LD50 values of potential drug candidates that would be active against the standard H37Rv strain of M. tuberculosis, by using the ProTox-II in silico tool. The molecules for which no structural hazard alerts were identified with these software tools were further subjected to molecular docking analyses and molecular dynamic simulations to estimate their ability to interact with the MtSK enzyme. Preliminary results from SwissADME indicated that 30 molecules were drug-like, due to their physicochemical and pharmacokinetic properties. However, subsequent analysis with ToxTree and ProTox-II indic...
Source: Alternatives to Laboratory Animals : ATLA - December 14, 2023 Category: Research Authors: Ashish Jhangiani Vandana Panda Aanchal Sukheja Sneha Thomas Piyush Dusseja Siddhartha Pandya Anand Chintakrindi Source Type: research

Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against < em > Mycobacterium tuberculosis < /em >
This study also aimed to predict LD50 values of potential drug candidates that would be active against the standard H37Rv strain of M. tuberculosis, by using the ProTox-II in silico tool. The molecules for which no structural hazard alerts were identified with these software tools were further subjected to molecular docking analyses and molecular dynamic simulations to estimate their ability to interact with the MtSK enzyme. Preliminary results from SwissADME indicated that 30 molecules were drug-like, due to their physicochemical and pharmacokinetic properties. However, subsequent analysis with ToxTree and ProTox-II indic...
Source: Alternatives to Laboratory Animals : ATLA - December 14, 2023 Category: Research Authors: Ashish Jhangiani Vandana Panda Aanchal Sukheja Sneha Thomas Piyush Dusseja Siddhartha Pandya Anand Chintakrindi Source Type: research

Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against < em > Mycobacterium tuberculosis < /em >
This study also aimed to predict LD50 values of potential drug candidates that would be active against the standard H37Rv strain of M. tuberculosis, by using the ProTox-II in silico tool. The molecules for which no structural hazard alerts were identified with these software tools were further subjected to molecular docking analyses and molecular dynamic simulations to estimate their ability to interact with the MtSK enzyme. Preliminary results from SwissADME indicated that 30 molecules were drug-like, due to their physicochemical and pharmacokinetic properties. However, subsequent analysis with ToxTree and ProTox-II indic...
Source: Alternatives to Laboratory Animals : ATLA - December 14, 2023 Category: Research Authors: Ashish Jhangiani Vandana Panda Aanchal Sukheja Sneha Thomas Piyush Dusseja Siddhartha Pandya Anand Chintakrindi Source Type: research

Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against < em > Mycobacterium tuberculosis < /em >
This study also aimed to predict LD50 values of potential drug candidates that would be active against the standard H37Rv strain of M. tuberculosis, by using the ProTox-II in silico tool. The molecules for which no structural hazard alerts were identified with these software tools were further subjected to molecular docking analyses and molecular dynamic simulations to estimate their ability to interact with the MtSK enzyme. Preliminary results from SwissADME indicated that 30 molecules were drug-like, due to their physicochemical and pharmacokinetic properties. However, subsequent analysis with ToxTree and ProTox-II indic...
Source: Alternatives to Laboratory Animals : ATLA - December 14, 2023 Category: Research Authors: Ashish Jhangiani Vandana Panda Aanchal Sukheja Sneha Thomas Piyush Dusseja Siddhartha Pandya Anand Chintakrindi Source Type: research

Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against < em > Mycobacterium tuberculosis < /em >
This study also aimed to predict LD50 values of potential drug candidates that would be active against the standard H37Rv strain of M. tuberculosis, by using the ProTox-II in silico tool. The molecules for which no structural hazard alerts were identified with these software tools were further subjected to molecular docking analyses and molecular dynamic simulations to estimate their ability to interact with the MtSK enzyme. Preliminary results from SwissADME indicated that 30 molecules were drug-like, due to their physicochemical and pharmacokinetic properties. However, subsequent analysis with ToxTree and ProTox-II indic...
Source: Alternatives to Laboratory Animals : ATLA - December 14, 2023 Category: Research Authors: Ashish Jhangiani Vandana Panda Aanchal Sukheja Sneha Thomas Piyush Dusseja Siddhartha Pandya Anand Chintakrindi Source Type: research

Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against < em > Mycobacterium tuberculosis < /em >
This study also aimed to predict LD50 values of potential drug candidates that would be active against the standard H37Rv strain of M. tuberculosis, by using the ProTox-II in silico tool. The molecules for which no structural hazard alerts were identified with these software tools were further subjected to molecular docking analyses and molecular dynamic simulations to estimate their ability to interact with the MtSK enzyme. Preliminary results from SwissADME indicated that 30 molecules were drug-like, due to their physicochemical and pharmacokinetic properties. However, subsequent analysis with ToxTree and ProTox-II indic...
Source: Alternatives to Laboratory Animals : ATLA - December 14, 2023 Category: Research Authors: Ashish Jhangiani Vandana Panda Aanchal Sukheja Sneha Thomas Piyush Dusseja Siddhartha Pandya Anand Chintakrindi Source Type: research

Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against < em > Mycobacterium tuberculosis < /em >
This study also aimed to predict LD50 values of potential drug candidates that would be active against the standard H37Rv strain of M. tuberculosis, by using the ProTox-II in silico tool. The molecules for which no structural hazard alerts were identified with these software tools were further subjected to molecular docking analyses and molecular dynamic simulations to estimate their ability to interact with the MtSK enzyme. Preliminary results from SwissADME indicated that 30 molecules were drug-like, due to their physicochemical and pharmacokinetic properties. However, subsequent analysis with ToxTree and ProTox-II indic...
Source: Alternatives to Laboratory Animals : ATLA - December 14, 2023 Category: Research Authors: Ashish Jhangiani Vandana Panda Aanchal Sukheja Sneha Thomas Piyush Dusseja Siddhartha Pandya Anand Chintakrindi Source Type: research

Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against < em > Mycobacterium tuberculosis < /em >
This study also aimed to predict LD50 values of potential drug candidates that would be active against the standard H37Rv strain of M. tuberculosis, by using the ProTox-II in silico tool. The molecules for which no structural hazard alerts were identified with these software tools were further subjected to molecular docking analyses and molecular dynamic simulations to estimate their ability to interact with the MtSK enzyme. Preliminary results from SwissADME indicated that 30 molecules were drug-like, due to their physicochemical and pharmacokinetic properties. However, subsequent analysis with ToxTree and ProTox-II indic...
Source: Alternatives to Laboratory Animals : ATLA - December 14, 2023 Category: Research Authors: Ashish Jhangiani Vandana Panda Aanchal Sukheja Sneha Thomas Piyush Dusseja Siddhartha Pandya Anand Chintakrindi Source Type: research

Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against < em > Mycobacterium tuberculosis < /em >
This study also aimed to predict LD50 values of potential drug candidates that would be active against the standard H37Rv strain of M. tuberculosis, by using the ProTox-II in silico tool. The molecules for which no structural hazard alerts were identified with these software tools were further subjected to molecular docking analyses and molecular dynamic simulations to estimate their ability to interact with the MtSK enzyme. Preliminary results from SwissADME indicated that 30 molecules were drug-like, due to their physicochemical and pharmacokinetic properties. However, subsequent analysis with ToxTree and ProTox-II indic...
Source: Alternatives to Laboratory Animals : ATLA - December 14, 2023 Category: Research Authors: Ashish Jhangiani Vandana Panda Aanchal Sukheja Sneha Thomas Piyush Dusseja Siddhartha Pandya Anand Chintakrindi Source Type: research

Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against < em > Mycobacterium tuberculosis < /em >
This study also aimed to predict LD50 values of potential drug candidates that would be active against the standard H37Rv strain of M. tuberculosis, by using the ProTox-II in silico tool. The molecules for which no structural hazard alerts were identified with these software tools were further subjected to molecular docking analyses and molecular dynamic simulations to estimate their ability to interact with the MtSK enzyme. Preliminary results from SwissADME indicated that 30 molecules were drug-like, due to their physicochemical and pharmacokinetic properties. However, subsequent analysis with ToxTree and ProTox-II indic...
Source: Alternatives to Laboratory Animals : ATLA - December 14, 2023 Category: Research Authors: Ashish Jhangiani Vandana Panda Aanchal Sukheja Sneha Thomas Piyush Dusseja Siddhartha Pandya Anand Chintakrindi Source Type: research

Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against < em > Mycobacterium tuberculosis < /em >
This study also aimed to predict LD50 values of potential drug candidates that would be active against the standard H37Rv strain of M. tuberculosis, by using the ProTox-II in silico tool. The molecules for which no structural hazard alerts were identified with these software tools were further subjected to molecular docking analyses and molecular dynamic simulations to estimate their ability to interact with the MtSK enzyme. Preliminary results from SwissADME indicated that 30 molecules were drug-like, due to their physicochemical and pharmacokinetic properties. However, subsequent analysis with ToxTree and ProTox-II indic...
Source: Alternatives to Laboratory Animals : ATLA - December 14, 2023 Category: Research Authors: Ashish Jhangiani Vandana Panda Aanchal Sukheja Sneha Thomas Piyush Dusseja Siddhartha Pandya Anand Chintakrindi Source Type: research

Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against < em > Mycobacterium tuberculosis < /em >
This study also aimed to predict LD50 values of potential drug candidates that would be active against the standard H37Rv strain of M. tuberculosis, by using the ProTox-II in silico tool. The molecules for which no structural hazard alerts were identified with these software tools were further subjected to molecular docking analyses and molecular dynamic simulations to estimate their ability to interact with the MtSK enzyme. Preliminary results from SwissADME indicated that 30 molecules were drug-like, due to their physicochemical and pharmacokinetic properties. However, subsequent analysis with ToxTree and ProTox-II indic...
Source: Alternatives to Laboratory Animals : ATLA - December 14, 2023 Category: Research Authors: Ashish Jhangiani Vandana Panda Aanchal Sukheja Sneha Thomas Piyush Dusseja Siddhartha Pandya Anand Chintakrindi Source Type: research

Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against < em > Mycobacterium tuberculosis < /em >
This study also aimed to predict LD50 values of potential drug candidates that would be active against the standard H37Rv strain of M. tuberculosis, by using the ProTox-II in silico tool. The molecules for which no structural hazard alerts were identified with these software tools were further subjected to molecular docking analyses and molecular dynamic simulations to estimate their ability to interact with the MtSK enzyme. Preliminary results from SwissADME indicated that 30 molecules were drug-like, due to their physicochemical and pharmacokinetic properties. However, subsequent analysis with ToxTree and ProTox-II indic...
Source: Alternatives to Laboratory Animals : ATLA - December 14, 2023 Category: Research Authors: Ashish Jhangiani Vandana Panda Aanchal Sukheja Sneha Thomas Piyush Dusseja Siddhartha Pandya Anand Chintakrindi Source Type: research

Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against < em > Mycobacterium tuberculosis < /em >
This study also aimed to predict LD50 values of potential drug candidates that would be active against the standard H37Rv strain of M. tuberculosis, by using the ProTox-II in silico tool. The molecules for which no structural hazard alerts were identified with these software tools were further subjected to molecular docking analyses and molecular dynamic simulations to estimate their ability to interact with the MtSK enzyme. Preliminary results from SwissADME indicated that 30 molecules were drug-like, due to their physicochemical and pharmacokinetic properties. However, subsequent analysis with ToxTree and ProTox-II indic...
Source: Alternatives to Laboratory Animals : ATLA - December 14, 2023 Category: Research Authors: Ashish Jhangiani Vandana Panda Aanchal Sukheja Sneha Thomas Piyush Dusseja Siddhartha Pandya Anand Chintakrindi Source Type: research