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< em > In Silico < /em > Prediction of Eye Irritation Using Hansen Solubility Parameters and Predicted pKa Values
Altern Lab Anim. 2023 May 15:2611929231175676. doi: 10.1177/02611929231175676. Online ahead of print.ABSTRACTAn in silico method has been developed that permits the binary differentiation between pure liquids causing serious eye damage or eye irritation, and pure liquids with no need for such classification, according to the UN GHS system. The method is based on the finding that the Hansen Solubility Parameters (HSP) of a liquid are collectively important predictors for eye irritation. Thus, by applying a two-tier approach in which in silico predicted pKa values (firstly) and a trained model based solely on in silico-predi...
Source: Alternatives to Laboratory Animals : ATLA - May 15, 2023 Category: Research Authors: Martin Andersson Ulf Norinder Swapnil Chavan Ian Cotgreave Source Type: research

Editorial
Altern Lab Anim. 2023 May 13:2611929231175315. doi: 10.1177/02611929231175315. Online ahead of print.NO ABSTRACTPMID:37177907 | DOI:10.1177/02611929231175315 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - May 13, 2023 Category: Research Source Type: research

A Human Cell-based Assay to Assess the Induction of Vasculature Formation for Non-genotoxic Carcinogenicity Testing Purposes: A Pilot Study
Altern Lab Anim. 2023 Apr 26:2611929231171165. doi: 10.1177/02611929231171165. Online ahead of print.ABSTRACTThe induction of vasculature formation is proposed to be a significant mechanism behind the non-genotoxic carcinogenicity of a chemical. The vasculature formation model used in this study is based on the coculture of human primary HUVECs and hASCs. This model was used to develop an assay to assess the induction of vasculature formation. Three assay protocols, based on different conditions, were developed and compared in order to identify the optimal conditions required. Some serum supplements and growth factors were...
Source: Alternatives to Laboratory Animals : ATLA - May 1, 2023 Category: Research Authors: Veera Hautanen Tarja Toimela Martin Paparella Tuula Heinonen Source Type: research