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Editorial
Altern Lab Anim. 2023 Oct 15:2611929231206692. doi: 10.1177/02611929231206692. Online ahead of print.NO ABSTRACTPMID:37840273 | DOI:10.1177/02611929231206692 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - October 16, 2023 Category: Research Authors: Judith C Madden Source Type: research

Spotlight on Three Rs Progress
Altern Lab Anim. 2023 Oct 15:2611929231206974. doi: 10.1177/02611929231206974. Online ahead of print.NO ABSTRACTPMID:37840284 | DOI:10.1177/02611929231206974 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - October 16, 2023 Category: Research Source Type: research

Resources Round-up
Altern Lab Anim. 2023 Oct 16:2611929231206955. doi: 10.1177/02611929231206955. Online ahead of print.NO ABSTRACTPMID:37843008 | DOI:10.1177/02611929231206955 (Source: Alternatives to Laboratory Animals : ATLA)
Source: Alternatives to Laboratory Animals : ATLA - October 16, 2023 Category: Research Source Type: research

Optimisation of a Method for the Differentiation of Human Umbilical Cord-derived Mesenchymal Stem Cells Toward Renal Epithelial-like Cells
This study evaluated the renal differentiation potential of hucMSCs, when exposed for 10 days to optimised concentrations of retinoic acid, activin-A and bone morphogenetic protein-7 (BMP-7) in various combinations, with and without the priming of the cells with a Wnt signalling pathway activator (CHIR99021). The hucMSCs were isolated and characterised according to surface marker expression (CD73, CD90, CD44, CD146 and CD8) and tri-lineage differentiation potential. The expression of key marker genes (OSR1, TBXT, HOXA13, SIX2, PAX2, KRT18 and ZO1) was examined by qRT-PCR. Specific marker protein expression (E-cadherin, cyt...
Source: Alternatives to Laboratory Animals : ATLA - October 13, 2023 Category: Research Authors: Rakhshinda Habib Shumaila Fahim Mohsin Wahid Jahanara Ainuddin Source Type: research

Development of an < em > In Vitro < /em > Sensitisation Test Using a Coculture System of Human Bronchial Epithelium and Immune Cells
Altern Lab Anim. 2023 Oct 5:2611929231204823. doi: 10.1177/02611929231204823. Online ahead of print.ABSTRACTChemical respiratory sensitisation is a serious health problem. However, to date, there are no validated test methods available for identifying respiratory sensitisers. The aim of this study was to develop an in vitro sensitisation test by modifying the human cell line activation test (h-CLAT) to detect respiratory sensitisers and distinguish them from skin sensitisers. THP-1 cells were exposed to the test chemicals (two skin sensitisers and six respiratory sensitisers), either as monocultures or as cocultures with a...
Source: Alternatives to Laboratory Animals : ATLA - October 5, 2023 Category: Research Authors: Ikuya Tanabe Kunitaka Yoshida Shinkichi Ishikawa Kanae Ishimori Tsuneo Hashizume Takayuki Yoshimoto Takao Ashikaga Source Type: research