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The Safety Assessment of Cosmetic Perfumes by Using < em > In Chemico < /em > and < em > In Vitro < /em > Methods in Combination with GC-MS/MS Analysis
Altern Lab Anim. 2023 Jun 28:2611929231184635. doi: 10.1177/02611929231184635. Online ahead of print.ABSTRACTAnimal testing has been prohibited for the safety assessment of cosmetic ingredients or finished products. Thus, alternative non-animal methods, followed by confirmatory clinical studies on human volunteers, should be used as the sole legally acceptable approach within the EU. The safety assessment of cosmetic products requires the involvement of multiple scientific disciplines, including analytical chemistry and biomedicine, as well as in chemico, in vitro and in silico toxicology. Recent data suggest that fragranc...
Source: Alternatives to Laboratory Animals : ATLA - June 28, 2023 Category: Research Authors: Mark éta Dvořáková Lada Svobodov á Marian Rucki V áclav Ševčík Barbora Ho šíková Jan Chrz Hana Bendov á Kristina Kejlov á Danu še Očadlíková Marek Mal ý Hana Kol ářová Marika Mannerstr öm Helena Kan ďárová Dagmar J írová Source Type: research

Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway
In this study, we evaluated the anti-angiogenic and anti-proliferative effects of a hydro-alcoholic extract of fenugreek seed (HAEF) on human umbilical vein endothelial cells (HUVECs). Human umbilical vein endothelial cells were treated with various concentrations of HAEF and the half-maximal inhibitory concentration (IC50) value was estimated by using the MTT assay. Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and matrix metalloproteinase enzyme (MMP-2 and MMP-9) gene expression profiles were evaluated by using quantitative RT-PCR (qRT-PCR). Moreover, MMP activities and PI3K, Akt and cy...
Source: Alternatives to Laboratory Animals : ATLA - June 22, 2023 Category: Research Authors: Samaneh Safarpour Farshad Mirzavi Farzad Rahmani Fatemeh Forouzanfar Hamid Reza Sadeghnia Baratali Mashkani Daryoush Hamidi Alamdari Mohammad Soukhtanloo Source Type: research

Is UK Animal Research Governance Facing a 'New Normal'? Considering the Risks and Benefits of 'Going Online'
Altern Lab Anim. 2023 Jun 21:2611929231180605. doi: 10.1177/02611929231180605. Online ahead of print.ABSTRACTSince a return to in-office working after the extensive disruption caused by the COVID-19 pandemic and associated challenges, many conversations are still being had with regard to what the 'new normal' might look like in professional spaces and networks, and what lessons can be learnt from long periods of remote working. The regulation of animal research practice in the UK is no exception here and, like many other systems, it has been transformed by the increasingly recognised value of streamlining procedures throug...
Source: Alternatives to Laboratory Animals : ATLA - June 21, 2023 Category: Research Authors: Kathleen Salter Source Type: research

Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022
Altern Lab Anim. 2023 Jun 6:2611929231180428. doi: 10.1177/02611929231180428. Online ahead of print.ABSTRACTAnimal experimentation has been integral to drug discovery and development and safety assessment for many years, since it provides insights into the mechanisms of drug efficacy and toxicity (e.g. pharmacology, pharmacokinetics and pharmacodynamics). However, due to species differences in physiology, metabolism and sensitivity to drugs, the animal models can often fail to replicate the effects of drugs and chemicals in human patients, workers and consumers. Researchers across the globe are increasingly applying the Th...
Source: Alternatives to Laboratory Animals : ATLA - June 7, 2023 Category: Research Authors: Nikita Narayan Naik Bharadwaja Vadloori Suresh Poosala Pratima Srivastava Sandra Coecke Adrian Smith Aysha Akhtar Clive Roper Sridhar Radhakrishnan Balaji Bhyravbhatla Madhujit Damle Venkat Koushik Pulla Johannes Hackethal Reyk Horland Albert P Li Falguni Source Type: research