[ASAP] Potentiometric Determination of Acid Dissociation Constants (p < italic toggle="yes" > K < /italic > < sub > a < /sub > ) for an Anticancer Pyrrole-Imidazole Polyamide
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00348 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - October 26, 2022 Category: Chemistry Authors: Xue Li, Zhaofang Shi, and Tiezheng Jia Source Type: research
[ASAP] Optimization of Pyrimidine Compounds as Potent JAK1 Inhibitors and the Discovery of R507 as a Clinical Candidate
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00411 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - October 25, 2022 Category: Chemistry Authors: Yan Chen, Hui Li, Rose Yen, Thilo J. Heckrodt, Darren McMurtrie, Rajinder Singh, Vanessa Taylor, Esteban S. Masuda, Gary Park, and Donald G. Payan Source Type: research
[ASAP] Covalent Modification of the JH2 Domain of Janus Kinase 2
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00414 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - October 24, 2022 Category: Chemistry Authors: Sean P. Henry, Maria-Elena Liosi, Joseph A. Ippolito, Fabian Menges, Ana S. Newton, Joseph Schlessinger, and William L. Jorgensen Source Type: research
[ASAP] Binding versus Enzymatic Processing of ε‑Trimethyllysine Dioxygenase Substrate Analogues
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00261 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - October 21, 2022 Category: Chemistry Authors: Diana Zelencova-Gopejenko, Aiga Grandane, Einars Loza, Daina Lola, Anda Sipola, Edgars Liepinsh, Pavel Arsenyan, and Kristaps Jaudzems Source Type: research
[ASAP] Fragment-Based Dynamic Combinatorial Chemistry for Identification of Selective α‑Glucosidase Inhibitors
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00405 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - October 19, 2022 Category: Chemistry Authors: Yao Wu, Changming Liu, and Lei Hu Source Type: research
[ASAP] Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00400 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - October 19, 2022 Category: Chemistry Authors: Stacey M. Southall, Joydeep Banerjee, Jason Brown, Kristina Butkovic, Andrew D. Cansfield, Julie E. Cansfield, Miles S. Congreve, Gabriella Cseke, Francesca Deflorian, Martina Petrovic Hunjadi, Antun Hutinec, Trinadh Kumar Inturi, Renata Rupcic, Gordon Sa Source Type: research
[ASAP] Discovery of Selective Inhibitors of Na < sub > V < /sub > 1.7 Templated on Saxitoxin as Therapeutics for Pain
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00378 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - October 18, 2022 Category: Chemistry Authors: Hassan Pajouhesh, Anton Delwig, Jacob T. Beckley ⊗, Sheri Klas⊗, Dennis Monteleone, Xiang Zhou, George Luu, J. Du Bois×, John C. Hunter, and John V. Mulcahy Source Type: research
[ASAP] Discovery of κ Opioid Receptor (KOR)-Selective < sc > d < /sc > ‑Tetrapeptides with Improved < italic toggle="yes" > In Vivo < /italic > Antinociceptive Effect after Peripheral Administration
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00237 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - October 17, 2022 Category: Chemistry Authors: Azzurra Stefanucci, Alice Della Valle, Giuseppe Scioli, Lorenza Marinaccio, Stefano Pieretti, Paola Minosi, Edina Szucs, Sandor Benyhe, Domiziana Masci, Parthasaradhireddy Tanguturi, Kerry Chou, Deborah Barlow, Karen Houseknecht, John M. Streicher, and Ad Source Type: research
[ASAP] The Invention of WM382, a Highly Potent PMIX/X Dual Inhibitor toward the Treatment of Malaria
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00355 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - October 12, 2022 Category: Chemistry Authors: Manuel de Lera Ruiz, Paola Favuzza, Zhuyan Guo, Lianyun Zhao, Bin Hu, Zhiyu Lei, Dongmei Zhan, Nicholas Murgolo, Christopher W. Boyce, Marissa Vavrek, Jennifer Thompson, Anna Ngo, Kate E. Jarman, Johnathan Robbins, Justin Boddey, Brad E. Sleebs, Kym N. Lo Source Type: research
[ASAP] Inhibition of β‑Amyloid Aggregation in Alzheimer’s Disease: The Key Role of (Pro)electrophilic Warheads
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00410 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - October 10, 2022 Category: Chemistry Authors: Filippo Basagni, Marina Naldi, Tiziana Ginex, F. Javier Luque, Francesca Fagiani, Cristina Lanni, Matteo Iurlo, Massimo Marcaccio, Anna Minarini, Manuela Bartolini, and Michela Rosini Source Type: research
[ASAP] Discovery of 5,7-Dihydro ‑6 < italic toggle="yes" > H < /italic > ‑pyrrolo[2,3‑ < italic toggle="yes" > d < /italic > ]pyrimidin-6-ones as Highly Selective CDK2 Inhibitors
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00408 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - October 6, 2022 Category: Chemistry Authors: Alexander Sokolsky, Sarah Winterton, Keith Kennedy, Katherine Drake, Kristine Stump, Lu Huo, Yvonne Lo, Min Ye, Maryanne Covington, Sharon Diamond, Yan-ou Yang, Sunkyu Kim, Swamy Yeleswaram, Liangxing Wu, and Wenqing Yao Source Type: research
[ASAP] Physicochemical and antiproliferative characteristics of RNA and DNA sequence-related G ‑quadruplexes
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00361 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - October 6, 2022 Category: Chemistry Authors: Weronika Kotkowiak, Carolina Roxo, and Anna Pasternak Source Type: research
[ASAP] Recent Discovery of PARP7 Inhibitors as Anticancer Agents
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00416 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - October 6, 2022 Category: Chemistry Authors: Robert B. Kargbo Source Type: research
[ASAP] Novel TYK2 Inhibitors with an < italic toggle="yes" > N < /italic > ‑(Methyl‑ < italic toggle="yes" > d < /italic > < sub > 3 < /sub > )pyridazine-3-carboxamide Skeleton for the Treatment of Autoimmune Diseases
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00334 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - October 6, 2022 Category: Chemistry Authors: Fei Liu, Bin Wang, Yanlong Liu, Wei Shi, Xujing Tang, Xiaojin Wang, Zhongyuan Hu, Ying Zhang, Yahui Guo, Xiayun Chang, Xiangyi He, Hongjiang Xu, and Ying He Source Type: research
[ASAP] Identification of Inhibitors of the < italic toggle="yes" > Schistosoma mansoni < /italic > VKR2 Kinase Domain
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00248 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - October 5, 2022 Category: Chemistry Authors: Indran Mathavan, Lawrence J. Liu, Sean W. Robinson, Nelly El-Sakkary, Adam Jo J. Elatico, Darwin Gomez, Ricky Nellas, Raymond J. Owens, William Zuercher ⧫, Iva Navratilova, Conor R. Caffrey, and Konstantinos Beis Source Type: research
