[ASAP] Antitubercular Activity of Novel 2 ‑(Quinoline-4-yloxy)acetamides with Improved Drug-Like Properties
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00254 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - July 21, 2022 Category: Chemistry Authors: Ana Fla ́via Borsoi, Laura Manzoli Alice, Nathalia Sperotto, Alessandro Silva Ramos, Bruno Lopes Abbadi, Fernanda Souza Macchi Hopf, Adilio da Silva Dadda, Raoní S. Rambo, Rodrigo Braccini Madeira Silva, Josiane Delgado Paz, Kenia Pissinate, Mauro Neve Source Type: research
[ASAP] A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00260 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - July 19, 2022 Category: Chemistry Authors: Subramanyam Vankadara, Monique Danielle Dawson, Jia Yi Fong, Qin Yao Oh, Qi An Ang, Boping Liu, Hong Yun Chang, Judice Koh, Xiaoying Koh, Qian Wen Tan, Joma Joy, and Cheng San Brian Chia Source Type: research
[ASAP] < italic toggle="yes" > N < /italic > ‑Alkyl-2-Quinolonopyrones Demonstrate Antimicrobial Activity against ESKAPE Pathogens Including < italic toggle="yes" > Staphylococcus aureus < /italic >
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00185 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - July 19, 2022 Category: Chemistry Authors: Eoin Moynihan, Katrina Mackey, Mark A. T. Blaskovich, F. Jerry Reen, and Gerard McGlacken Source Type: research
[ASAP] Discovery of Desmuramylpeptide NOD2 Agonists with Single-Digit Nanomolar Potency
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00121 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - July 18, 2022 Category: Chemistry Authors: Samo Guzelj, S ̌pela Bizjak, and Žiga Jakopin Source Type: research
[ASAP] SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00223 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - July 15, 2022 Category: Chemistry Authors: Andrew D. Huber, Yongtao Li, Wenwei Lin, Annalise N. Galbraith, Ashutosh Mishra, Shaina N. Porter, Jing Wu, Rebecca R. Florke Gee, Wei Zhuang, Shondra M. Pruett-Miller, Junmin Peng, and Taosheng Chen Source Type: research
[ASAP] An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00166 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - July 14, 2022 Category: Chemistry Authors: Silvio Aprile, Giorgia Colombo, Marta Serafini, Rosanna Di Paola, Federica Pisati, Irene Preet Bhela, Salvatore Cuzzocrea, Giorgio Grosa, and Tracey Pirali Source Type: research
[ASAP] Tricyclic Carboxamide Derivatives as PRMT5 Inhibitors for Treating Cancer
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00292 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - July 12, 2022 Category: Chemistry Authors: Ram W. Sabnis Source Type: research
[ASAP] Innovation Experiences from Africa-Led Drug Discovery at the Holistic Drug Discovery and Development (H3D) Centre
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00142 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - July 11, 2022 Category: Chemistry Authors: Vinayak Singh, Dickson Mambwe, Constance Mawunyo Korkor, and Kelly Chibale Source Type: research
[ASAP] Discovery of Novel Aldo-Keto Reductase 1C3 Inhibitors as Chemotherapeutic Potentiators for Cancer Drug Resistance
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00175 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - July 8, 2022 Category: Chemistry Authors: Siyu He, Yang Liu, Xianglin Chu, Qi Li, Weiping Lyu, Yijun Liu, Shuaishuai Xing, Feng Feng, Wenyuan Liu, Qinglong Guo, Li Zhao, and Haopeng Sun Source Type: research
[ASAP] Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro ‑8 < italic toggle="yes" > H < /italic > ‑purin-8-one Inhibitors of DNA-PK
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00172 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - July 7, 2022 Category: Chemistry Authors: Frederick W. Goldberg, Attilla K. T. Ting, David Beattie, Gillian M. Lamont, Charlene Fallan, M. Raymond V. Finlay, Beth Williamson, Marianne Schimpl, Alexander R. Harmer, Oladipupo B. Adeyemi, Pa ̈r Nordell, Anna S. Cronin, Mercedes Vazquez-Chantada, De Source Type: research
[ASAP] Small-Molecule Inhibitors of the MLL1 CXXC Domain, an Epigenetic Reader of DNA Methylation
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00198 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - July 7, 2022 Category: Chemistry Authors: Hanuman P. Kalmode, Izabella Podsiadly, Ashish Kabra, Adam Boulton, Prabhakar Reddy, Yan Gao, Christopher Li, and John H. Bushweller Source Type: research
[ASAP] Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00219 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - July 5, 2022 Category: Chemistry Authors: Matthew D. Hill, Haiquan Fang, Derek Norris, George V. Delucca, Hong Huang, Mikkel DeBenedetto, Claude Quesnelle, William D. Schmitz, John S. Tokarski, Steven Sheriff, Chunhong Yan, Caroline Fanslau, Zuzana Haarhoff, Christine Huang, Melissa Kramer, Shilp Source Type: research
[ASAP] Inhibitor Screen Identifies Covalent Inhibitors of the Protein Histidine Phosphatase PHPT1
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00053 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - July 5, 2022 Category: Chemistry Authors: Brandon S. McCullough, Hanfei Wang, and Amy M. Barrios Source Type: research
[ASAP] 6,7-Dihydro ‑5 < italic toggle="yes" > H < /italic > ‑benzo[7]annulene Compounds as Selective Estrogen Receptor Degraders for Treating Cancer
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00287 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - July 4, 2022 Category: Chemistry Authors: Ram W. Sabnis Source Type: research
[ASAP] Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.2c00084 (Source: ACS Medicinal Chemistry Letters)
Source: ACS Medicinal Chemistry Letters - June 30, 2022 Category: Chemistry Authors: Santo Previti, Roberta Ettari, Elsa Calcaterra, Carla Di Chio, Rahul Ravichandran, Collin Zimmer, Stefan Hammerschmidt, Annika Wagner, Marta Bogacz, Sandro Cosconati, Tanja Schirmeister, and Maria Zappala ̀ Source Type: research
