A List of Trials of Stem Cell Therapies Aimed at Slowing Aging
To what degree can the current panoply of stem cell therapies slow the progression of aging? A great many trials have been conducted, largely of cell therapies wherein the principle mode of action is reduction of chronic inflammatory signaling. This has value, but it remains the case that the original vision of greatly enhanced regeneration and transplanted cells surviving to support tissue for the long term has yet to be realized. The paper here provides a concrete list of trials and various different strategies for the production of first generation stem cell therapies; good reading for those interested in seeking out th...
Source: Fight Aging! - May 5, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Government Proposes To Make Bad Standards on Race and Ethnicity Worse
John F. EarlyI recently laid out the case to stop government classification of people by race and ethnicity in a CatoBlog post. Those observations were stimulated by The Office of Management and Budget (OMB) posting a notice for comment in the Federal Register with respect to a report from the Federal Interagency Technical Working Group and Race and Ethnicity Standards to revise the existing standards for collecting data by race and ethnicity. Comments are due by April 27, 2023.Ipublished a similar op ‐ed in the Wall Street Journal, which subsequently printed a singleletter to the editor in re...
Source: Cato-at-liberty - April 18, 2023 Category: American Health Authors: John F. Early Source Type: blogs
Forkhead box O3 protein (FOXO3) genes and longevity
Approximately 25 –32% of the overall variation in adult lifespan is accounted for by genetic differences that become particularly important for survivalafter the age of 60.Forkhead box O3 protein (FOXO3) is a transcription factor involved in the regulation of genes involved in many cellular processes, including DNA repair, tumor suppression, immune function, and resistance to oxidative stress. Some variants of FOXO3 are associated with longevity in humans.FOXO3 is onchromosome 6. FOXO3A encodes a keyregulator of the insulin –IGF1 signaling pathway that is known to influence metabolism and lifespan. A study of...
Source: Clinical Cases and Images - Blog - April 15, 2023 Category: Universities & Medical Training Tags: Genetics Source Type: blogs
Trump As Catalyst For Legal and Cultural Reform
BY MIKE MAGEE
Former President Donald Trump’s indictment this morning reinforces most Americans’ belief that “No man is above the law.” But few of us have taken the time to explore what that statement means when it comes to building a healthy nation, and why we believe it.
How do you create a healthy nation?
This is at once a very simple and a very complex question. It is at the heart of successful and failed nation building.
It applies equally to a self-assessment of our approach to rebuilding Germany and Japan as part of the Marshall Plan after WW II, and to our own struggl...
Source: The Health Care Blog - April 5, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Common Law Donald Trump Indictment Mike Magee Source Type: blogs
Japan's New Security Policies: A Long Road to Full Implementation
The historic ambition contained within Japan ' s new defense strategies is notable. But the reality is that an extraordinary alignment of political, economic, fiscal, and other stars will be necessary for Japan ' s government to fully implement their stated ambitions over the next 5–10 years. (Source: The RAND Blog)
Source: The RAND Blog - March 27, 2023 Category: Health Management Authors: Jeffrey W. Hornung Source Type: blogs
Fast Facts about the U.S. Federal Debt
Romina BocciaHigh and rising government debt slows growth, crowds out private investment, limits the government ’s ability to respond to unexpected emergencies, and elevates the risk of a sudden fiscal crisis, where investors would lose confidence in U.S. Treasury bonds and the U.S. dollar. This fact sheet lays out everything legislators and the public need to know about the U.S. federal debt to help them examine the unsustainability of the U.S. budget.The total or gross federal debt is$31.5 trillion. This is the debt subject to the debt limit.At120 percent of gross domestic product (GDP), the gross federal debt exceeds...
Source: Cato-at-liberty - March 23, 2023 Category: American Health Authors: Romina Boccia Source Type: blogs
3 Ways to Develop an ‘Ever-Young’ Mind by Asking Ourselves Questions
Jiddu Krishnamurti (1895–1986) was an exceptional thinker and mystic. One of the baffling features of his thought and discourse was his insistence on rejecting the traditional role of a spiritual authority and refusing to provide answers to his listeners. Participants in his public talks and dialogues were often surprised when Krishnamurti would pose questions such as ‘What is the meaning of life?’ negate all imaginable answers, and leave the questions hanging and his audience empty-handed. For Krishnamurti, this was his way of awakening the intelligence of his listeners, throwing them back on themselves.
Ordinari...
Source: PickTheBrain | Motivation and Self Improvement - March 21, 2023 Category: Consumer Health News Authors: Erin Falconer Tags: creativity featured happiness meditation motivation philosophy psychology self-improvement ever-young mind Source Type: blogs
Banking the Unbanked: The Policies That Get In the Way
Walter OlsonI ’ve written two previous posts summarizing observations of consumer finance blogger Patrick McKenzie on, respectively, why laws against lying to banksare drawn to serve the interests of prosecutors and why the culture of regulatory complianceis ingratiating in a literally cringey way. I ’ll finish the series with a few excerpts from his posts on a theme familiar to Cato readers: why the oft ‐discussed predicament of the unbanked — persons, often living at social margins, who lack bank accounts — is to an important extent driven by government policies themselves.As one example ...
Source: Cato-at-liberty - March 21, 2023 Category: American Health Authors: Walter Olson Source Type: blogs
Breaking down the barriers to effective bar-code medication administration
According to the Commonwealth Fund and the Organisation for Economic Co-operation and Development (OECD), the health care system in the United States continues to rank the highest in health spending, has the highest rates of avoidable deaths, and rates of infant and maternal deaths compared to other high-income countries. These countries include Australia, Canada, France, Germany, Japan, the
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Breaking down the barriers to effective bar-code medication administration originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 18, 2023 Category: General Medicine Authors: Amy Dang Craft Tags: Policy Public Health & Policy Source Type: blogs
Health care economics 101
I don ' t actually like the term " health care " (or healthcare, sometimes it ' s even one word). That implies that it ' s about two things -- health and care -- whereas it ' s more about disease than health and more about money than care. In fact, the money part is very notable: it ' s really expensive, more and more so all the time: Right now it ' s at about 18% of GDP. Well, you might say, that ' s because medical technology has gotten better and better, there ' s good reason to spend more on it. There is some truth to that, but then there ' s this: Hmm. We ' re spending twice as much as the averag...
Source: Stayin' Alive - March 6, 2023 Category: American Health Source Type: blogs
Alpha TAU Killing Tumors With Highly Targeted Alpha Radiation
Radiation is commonly employed in hospitals around the world to treat tumors, typically using gamma ray beams of high energy photons, with a relatively long range, that penetrate all the tissues on the way to and from the tumor. This leads to substantial damage to healthy tissues and too often results in poor outcomes. An alpha particle, consisting of two protons and two neutrons bound together and akin to a helium-4 nucleus, is much trickier to work with in medicine because it is extremely powerful, yet has a very short effective range.
Ronen Segal
We recently visited the offices of Alpha TAU, a company based in Jeru...
Source: Medgadget - March 2, 2023 Category: Medical Devices Authors: Medgadget Editors Tags: Exclusive Oncology Radiation Oncology TelAvivUni Source Type: blogs
There Is Something About Trains, Indeed
BY KIM BELLARD
Like many of you, when I heard about the Norfolk Southern train derailment in East Palestine (OH) on February 3, my heart went out to the people in that community. The train was carrying some hazardous materials, and no one was quite sure what was vented, especially when officials did a “controlled burn.” Still, though, I didn’t think much about it; although I live in Ohio, I’m about as far away as one can be within the state.
Yesterday my local water company shut off access to water from the Ohio River. “We are taking this preventative step to ensure the health, safety, and confidence ...
Source: The Health Care Blog - February 21, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Non-Health infrastructure demands Kim Bellard Palestine Trains Source Type: blogs
Dual antidote for cyanide and carbon monoxide poisoning
TL:DR – Scientists have developed a life-saving antidote for exposure to the deadly gases hydrogen cyanide and carbon monoxide.
Scientists have made a groundbreaking discovery in the field of antidote development by creating a synthetic heme-model compound that has the potential to save lives in the event of simultaneous poisoning by carbon monoxide and hydrogen cyanide, which are frequently encountered in building fires. The compound, which has been tested on mice, resulted in an impressive 85% survival rate and rapid recovery. The chemical group known as heme is at the heart of hemoglobin, the oxygen-carrying mole...
Source: David Bradley Sciencebase - Songs, Snaps, Science - February 20, 2023 Category: Science Authors: David Bradley Tags: Chemistry Health and Medicine Source Type: blogs
Fight Aging! Newsletter, February 20th 2023
In this study, researchers stimulate the ghrelin receptor using a suitable small molecule for much of the lifespan of mice, and observe the results. The overall extension of life span is a quarter of that produced by calorie restriction, and so we might draw some conclusions from that as to the relative importance of hunger in the benefits resulting from the practice of calorie restriction or fasting. Interestingly, the short term weight gains observed in mice given this ghrelin receptor agonist in the past don't appear in this long term study, in which the controls are the heaver animals. This is possibly because the rese...
Source: Fight Aging! - February 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Digging Deeper into the Epigenetics of Supercentenarians
Supercentenarians, much as one might expect, exhibit signs of being biologically younger than their years. It is a lower burden of age-related damage and dysfunction that allows them the chance to survive. That said, it is worth noting that many characteristics so far observed in studies of supercentenarians are also present in large numbers of people who die well before reaching a century of life. The fortunately biochemistry of supercentarians adjusts small odds of survival to be slightly more favorable, but still small odds of survival. It is far from an assurance, and it certainly doesn't prevent one from becoming frai...
Source: Fight Aging! - February 17, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
