International Medicine & Public Health Clinical Trials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Takeda ’s Dengue Vaccine Recommended by World Health Organization Advisory Group for Introduction in High Dengue Burden and Transmission Areas in Children Ages Six to 16 Years
Experts Reviewed Data from Qdenga’s Clinical Program Across 19 Phase 1, 2 and 3 Trials with More Than 28,000 Participants WHO Will Consider the SAGE Recommendation and Provide Final Guidance on the Use of Qdenga in Public Vaccination... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - October 3, 2023 Category: Pharmaceuticals Source Type: clinical trials

Effectiveness and safety of digital rectal stimulation and abdominal massage for neurogenic bowel dysfunction in stroke patients: a randomized controlled trial protocol
This study follows a prospective randomized controlled parallel-group clinical trial design. The control group will receive standard care, while the intervention group will undergo a program that combines DRS and abdominal massage in addition to standard care. The duration of the intervention for both groups will be 6 weeks. The primary outcome measures will be the Wexner score. Furthermore, secondary outcomes measure will be assessed, including Bristol score, Patient Assessment of Constipation-Quality of Life (PAC-QoL), and Fecal Incontinence Quality of Life (FI-QoL).DiscussionThis study aims to evaluate the effectivene...
Source: Trials - October 3, 2023 Category: Research Source Type: clinical trials

R21/Matrix-M ™ Malaria Vaccine with Novavax’s Adjuvant Technology Receives WHO Recommendation
October 2, 2023 - Today, the World Health Organization (WHO) announced its recommendation of the R21/Matrix-M™ malaria vaccine to prevent malaria in children following advice from its Strategic Advisory Group of Experts (SAGE) and Malaria... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - October 2, 2023 Category: Pharmaceuticals Source Type: clinical trials

Motivational Interviewing for Vaccine Uptake in Latinx Adults
Conditions: Vaccine Hesitancy Interventions: Other: EHR alert; Behavioral: Motivational Interviewing; Behavioral: Warm hand off to nurse Sponsors: Boston College; East Boston Neighborhood Health Center; Harvard School of Public Health (HSPH); Boston Children ' s Hospital; National Institute of Nursing Research (NINR) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 2, 2023 Category: Research Source Type: clinical trials

Modified Dosage for Severe Acute Malnutrition
Conditions: Severe Acute Malnutrition Interventions: Dietary Supplement: ready-to-use therapeutic food (RUTF); Drug: Amoxicillin Sponsors: Action Against Hunger USA; University of Washington; Ethiopian Public Health Institute Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 29, 2023 Category: Research Source Type: clinical trials

Modified Dosage for Moderate Acute Malnutrition (MODAM-MAM)
Conditions: Moderate Acute Malnutrition Interventions: Dietary Supplement: ready-to-use supplementary food (RUSF); Dietary Supplement: ready-to-use therapeutic food (RUTF); Drug: Amoxicillin Sponsors: Action Against Hunger USA; University of Washington; Ethiopian Public Health Institute Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 27, 2023 Category: Research Source Type: clinical trials

A study protocol for Project I-Test: a cluster randomized controlled trial of a practice coaching intervention to increase HIV testing in substance use treatment programs
This study is one of the first to test organizational approaches (practice coaching) to increase HIV and HIV/HCV testing and linkage to care among individuals receiving treatment for opioid use disorder. The study may provide valuable insight and knowledge on the multiple levels of intervention that, if integrated, may better position OTPs to improve and sustain testing practices and improve population health.Trial registrationClinicalTrials.gov NCT03135886. Registered on 2 May 2017. (Source: Trials)
Source: Trials - September 26, 2023 Category: Research Source Type: clinical trials

Palliative care for persons with late-stage Alzheimer ’s and related dementias and their caregivers: protocol for a randomized clinical trial
DiscussionThe study results will determine the efficacy of an intervention that addresses the extraordinary public health impact of late-stage ADRD and suffering due to symptom distress, burdensome treatments, and caregiver strain. While many caregivers prioritize comfort in late-stage ADRD, shared decision-making is rare. Hospitalization creates an opportunity for dementia-specific palliative care, and the study findings will inform care redesign to advance comprehensive dementia-specific palliative care plus transitional care.Trial registrationClinicalTrials.gov NCT04948866. Registered on July 2, 2021. (Source: Trials)
Source: Trials - September 25, 2023 Category: Research Source Type: clinical trials

The Elders' Resilience Curriculum
Conditions: Suicidal Ideation Interventions: Behavioral: Elders ' Resilience Curriculum Sponsors: Johns Hopkins Bloomberg School of Public Health; National Institutes of Health Clinical Center (CC) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials

Therapeutic Efficacy of Chloroquine Plus Primaquine in the Treatment of Uncomplicated Plasmodium Vivax
Conditions: Efficacy; Malaria; Chloroquine; Vivax Malaria Interventions: Drug: Chloroquine; Drug: Primaquine Sponsors: Dinka Dugassa; Ethiopian Public Health Institute Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials

Reducing antimicrobial overuse through targeted therapy for patients with community-acquired pneumonia: a study protocol for a cluster-randomized factorial controlled trial (CARE-CAP)
DiscussionOur study aims to determine whether identifying an etiological agent early and pharmacist-led de-escalation (calling attention to negative cultures) can safely reduce the use of ESA in patients with CAP. If successful, our findings should lead to better antimicrobial stewardship, as well as improved patient outcomes and reduced healthcare costs. Our findings may also inform clinical guidelines on the optimal management of CAP.Trial registrationClinicalTrials.govNCT05568654. Registered on October 4, 2022. (Source: Trials)
Source: Trials - September 16, 2023 Category: Research Source Type: clinical trials

CRADLE-5: a stepped-wedge type 2 hybrid implementation-effectiveness cluster randomised controlled trial to evaluate the real-world scale-up of the CRADLE Vital Signs Alert intervention into routine maternity care in Sierra Leone —study protocol
DiscussionInternational guidance recommends that all pregnant and postpartum women have regular blood pressure assessment, and healthcare staff are adequately trained to respond to abnormalities. Clinical effectiveness to improve maternal and perinatal health in more rural areas, and ease of integration and sustainability of the CRADLE intervention at scale has yet to be investigated. This trial will explore whether national scale-up of the CRADLE intervention reduces maternal and fetal mortality and severe maternal adverse outcomes and understand the strategies for adoption, integration and sustainability in low-resource ...
Source: Trials - September 15, 2023 Category: Research Source Type: clinical trials

B-free Multistage Trial
Conditions: HIV; Drug Resistance; Drug Drug Interaction Intervention: Drug: DOR/DTG/3TC Sponsors: Insel Gruppe AG, University Hospital Bern; Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland; University of Bern Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 14, 2023 Category: Research Source Type: clinical trials