Associate Principal Investigators and the HEAL-COVID trial: good for trainees, good for trials
This study adds to the growing literature that the NIHR ’s API Scheme is effective in meeting its objectives in providing research training to clinicians, thus building a workforce of future clinical researchers. Moreover, data from the HEAL-COVID trial shows that sites with an API are associated with higher recruitment. Overall, registering a trial wi th the API Scheme not only trains future clinical researchers, but it is also likely to increase the number of patients recruited (amongst other benefits), increasing the efficiency of trials and improving access for patients. (Source: Trials)
Source: Trials - January 27, 2024 Category: Research Source Type: clinical trials

Antenatal Multiple Micronutrient Supplementation (MMS) in Indonesia
Conditions: Nutrient Deficiency Interventions: Behavioral: MMS (90x2) + BCC or expanded BCC; Behavioral: MMS (180x1) + BCC or expanded BCC Sponsors: Johns Hopkins Bloomberg School of Public Health; Indonesia University; Hasanuddin University; Universitas Airlangga; Vitamin Angels Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 26, 2024 Category: Research Source Type: clinical trials

Arogya Sangama: 3 Way Partnership of People, Providers, and Panchayat for Health
Conditions: Health Care Utilization; Health Care Seeking Behavior; Health Knowledge, Attitudes, Practice Interventions: Behavioral: Arogya Sangama Sponsors: Johns Hopkins Bloomberg School of Public Health; Karnataka Health Promotion Trust Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2024 Category: Research Source Type: clinical trials

Acceptability and Nutritional Impact of Double-fortified Salt Containing Iodine and Folic Acid
Conditions: Folate Deficiency; Iodine Deficiency; Anemia Macrocytic; Anemia Deficiency; Salt Intake; Vitamin B 12 Deficiency Interventions: Dietary Supplement: Iodized salt with or without one of two levels of folic acid Sponsors: University of California, Davis; Ethiopian Public Health Institute; University of California, San Francisco; University of Rhode Island; Nutrition International Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2024 Category: Research Source Type: clinical trials

Study to Evaluate Safety and Immunogenicity of a Prime-Boost Regimen of rVSV-Nipah Virus Vaccine Candidate PHV02 in Healthy Adult Subjects
Conditions: Nipah Virus Infection Interventions: Biological: PHV02; Biological: Lactated Ringer ' s Sponsors: Public Health Vaccines LLC; Coalition for Epidemic Preparedness Innovations Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 24, 2024 Category: Research Source Type: clinical trials

To Assess the Impact of theERAS Consensus on Patients With Endoscopic Pituitary Tumor Surgery
Conditions: Enhanced Recovery After Surgery; Pituitary Tumor; Postoperative Complications Interventions: Diagnostic Test: Malnutrition Universal Screening Tool; Device: TIB Olfactory Test Device; Diagnostic Test: Apfel Score for Postoperative nausea and vomiting; Diagnostic Test: The American Society of Anesthesiologists (ASA) Physical Status Classification; Behavioral: Short Form-36; Behavioral: World Health Organization Quality of Life questionnaire (WHOQOL-BREF); Behavioral: BDI-II(Beck Depression Inventory-II); Behavioral: ERAS Patient Satisfaction Questionnaire(ERAS-PSQ); Behavioral: Quality of Recovery-40(QoR-40) Spo...
Source: ClinicalTrials.gov - January 24, 2024 Category: Research Source Type: clinical trials

Pragmatic randomized controlled trials: strengthening the concept through a robust international collaborative network: PRIME-9 —Pragmatic Research and Innovation through Multinational Experimentation
AbstractIn an era focused on value-based healthcare, the quality of healthcare and resource allocation should be underpinned by empirical evidence. Pragmatic clinical trials (pRCTs) are essential in this endeavor, providing randomized controlled trial (RCT) insights that encapsulate real-world effects of interventions. The rising popularity of pRCTs can be attributed to their ability to mirror real-world practices, accommodate larger sample sizes, and provide cost advantages over traditional RCTs. By harmonizing efficacy with effectiveness, pRCTs assist decision-makers in prioritizing interventions that have a substantial ...
Source: Trials - January 23, 2024 Category: Research Source Type: clinical trials

Food Is Medicine: Makin' Healthy Groceries
Conditions: Hypertension Interventions: Behavioral: Grocery Vouchers Sponsors: Duke University; American Heart Association; Rouses Market; Instacart; Duke Clinical Research Institute; University Medical Center New Orleans - LCMC Health; Louisiana Public Health Institute Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 22, 2024 Category: Research Source Type: clinical trials

Feasibility Study of the Proposed Test-and-treat Screening Program in Younger Participants With H. Pylori Infection
Conditions: Helicobacter Pylori Infection Interventions: Drug: Bismuth Subcitrate; Drug: Esomeprazole; Drug: Metronidazole; Drug: Amoxicillin; Drug: Clarithromycin; Drug: Levofloxacin Sponsors: National Institute of Public Health, Slovenia; Community Healthcare Center dr. Adolf Drolc Maribor (HCM) Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 22, 2024 Category: Research Source Type: clinical trials

Optimizing the use of ketamine to reduce chronic postsurgical pain in women undergoing mastectomy for oncologic indication: study protocol for the KALPAS multicenter randomized controlled trial
This study can substantially impact perioperative pain management and can contribute significantly to combatting the opioid epidemic.Trial registrationClinicalTrials.gov NCT05037123. Registered on September 8, 2021. (Source: Trials)
Source: Trials - January 19, 2024 Category: Research Source Type: clinical trials

Staph Intervention for Effective Local Defense
Conditions: Staphylococcus Aureus Infection Interventions: Combination Product: Mupirocin + Nozin + chlorhexidine gluconate; Behavioral: Education + Household supplies Sponsors: Johns Hopkins Bloomberg School of Public Health; National Institute of General Medical Sciences (NIGMS) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 18, 2024 Category: Research Source Type: clinical trials

Effectiveness of a Community Intervention in the Chronic Use of Benzodiazepines: (BENZOSTOPJUNTOS)
Conditions: Inappropriate Prescribing Interventions: Behavioral: Intervention for reducing benzodiacepines long-term use. Sponsors: Andalusian Health Service; Andalusian School of Public Health Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 18, 2024 Category: Research Source Type: clinical trials

Hepatitis C Virus Self-testing (HCVST) in Sexual and Gender Minorities in Rio de Janeiro
Conditions: Hepatitis C Interventions: Diagnostic Test: Hepatitis C virus self-test (oral fluid HCVST); Diagnostic Test: Hepatitis C virus self-test (blood-based HCVST) Sponsors: Oswaldo Cruz Foundation; World Health Organization; UNITAID Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 12, 2024 Category: Research Source Type: clinical trials

Delivering COVID-19 vaccine trials at speed: the implementation of a phase IV UK multi-centre randomised controlled trial to determine safety and immunogenicity of COVID-19 vaccines co-administered with seasonal influenza vaccines (ComFluCOV)
ConclusionThe rapid delivery of ComFluCOV was resource intensive. It was made possible in part due to a unique set of circumstances created by the pandemic situation including measures put in place to support urgent public health research and public support for COVID-19 vaccine research. Elements of the trial could be adopted to increase efficiency in ‘non-pandemic’ situations including working with a clinical trials unit to enable immediate mobilisation of a team of experienced researchers, greater sharing of resources between clinical trials units, use of electronic trial systems and virtual meetings.Trial registrati...
Source: Trials - January 11, 2024 Category: Research Source Type: clinical trials

Implementation of a New Model of Care for Supporting Long-term Medication Adherence
Conditions: Medication Initiation for Long-term Conditions Interventions: Behavioral: myCare Start Sponsors: University of Geneva, Switzerland; University of Basel; Fundaci ó Sant Joan de Déu; pharmaSuisse, Switzerland; Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland; University of Bern Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 5, 2024 Category: Research Source Type: clinical trials