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Gra-CRC-miRTar: The pre-trained nucleotide-to-graph neural networks to identify potential miRNA targets in colorectal cancer
bioRxiv [Preprint]. 2024 Apr 20:2024.04.15.589599. doi: 10.1101/2024.04.15.589599.ABSTRACTColorectal cancer (CRC) is the third most diagnosed cancer and the second deadliest cancer worldwide representing a major public health problem. In recent years, increasing evidence has shown that microRNA (miRNA) can control the expression of targeted human messenger RNA (mRNA) by reducing their abundance or translation, acting as oncogenes or tumor suppressors in various cancers, including CRC. Due to the significant up-regulation of oncogenic miRNAs in CRC, elucidating the underlying mechanism and identifying dysregulated miRNA tar...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Rui Yin Hongru Zhao Lu Li Qiang Yang Min Zeng Carl Yang Jiang Bian Mingyi Xie Source Type: research

E-cigarettes in Nigeria: A scoping review of evidence
CONCLUSION: There is an urgent need for more scientific investigations on the sociodemographic, economic, health, and regulatory landscape of e-cigarettes in Nigeria, as robust empirical evidence is needed for the effective planning, implementation, and evaluation of evidence-based policies and interventions on e-cigarettes control and regulation in Nigeria.PMID:38660005 | PMC:PMC11040567 | DOI:10.1002/hsr2.2074 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Oluwatobi E Adegbile Oluwatomilayo D Adeniji Jimoh Amzat Kehinde K Kanmodi Source Type: research

Cervical Cancer Stigma Among Caribbean Population: A Descriptive Paper
Conclusion: Cancer stigma of cervical cancer exists in Jamaica, Trinidad and Tobago, and Grenada. Particularly, cultural background and social norms are closely linked to stigma.PMID:38660496 | PMC:PMC11039822 | DOI:10.3389/ijph.2024.1606725 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Kamilah Thomas-Purcell Althea Bailey Diadrey-Anne Sealy Gaole Song Kimlin Tam Ashing Source Type: research

A Scale for Measuring Electronic Patient Engagement Behaviors: Development and Validation
(Source: Patient Preference and Adherence)
Source: Patient Preference and Adherence - April 25, 2024 Category: International Medicine & Public Health Tags: Patient Preference and Adherence Source Type: research

Overview of the Epidemiology and Clinical Care Considerations for Adolescents and Young Adults Living with or at Risk of Human Immunodeficiency Virus
This article provides an updated examination of human immunodeficiency virus (HIV) epidemiologic trends among adolescents and young adults (AYAs) in the United States, highlighting the significant public health challenge posed by HIV within this demographic. Despite a notable decline in HIV diagnoses among AYAs, challenges remain, particularly due to 50% of AYAs living with HIV being unaware of their status. The article aims to evaluate current clinical recommendations, identify deficiencies, and propose evidence-based improvements for HIV prevention, diagnosis, and care, with the goal of enhancing health outcomes and redu...
Source: Nursing Clinics of North America - April 25, 2024 Category: Nursing Authors: Adam Leonard, Brenice Duroseau Source Type: research

Buprenorphine prescribing and treatment accessibility in response to regulation changes due to the COVID-19 public health emergency
This study aims to explore trends in buprenorphine treatment initiation pre- and post-public health emergency to evaluate changes in the context of X-waiver relaxations and telehealth allowances. (Source: Journal of Substance Abuse Treatment)
Source: Journal of Substance Abuse Treatment - April 25, 2024 Category: Addiction Authors: Taylor J. Paiva, Rachel S. Wightman, Kristen St. John, Adam Z. Nitenson, Collette Onyejekwe, Benjamin D. Hallowell Source Type: research

Medical students ’ knowledge about human papillomavirus (HPV), HPV vaccine and head and neck cancer
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - April 25, 2024 Category: Allergy & Immunology Authors: Norangelys Solis-TorresIsardo Braverman-DiazLuis A. Rivera-MoralesJose J. Perez-SanchezValeria S. Perez-BravoAngel J. Neris-SanchezAlexis VeraYaritza Diaz-AlgorriMaster of Public Health Program, San Juan Bautista School of Medicine, Caguas, Puerto Rico Source Type: research

COVID-19 clinical trial participation and awareness in Texas
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - April 25, 2024 Category: Allergy & Immunology Authors: Justin M. LuninghamIdara N. AkpanSarah AlkhatibTanjila TaskinPalak DesaiJamboor K. VishwanathaErika L. Thompsona Department of Population & Community Health, School of Public Health, University of North Texas Health Science Center at Fort Worth, Fort Wor Source Type: research

Cascade testing for hereditary cancer in Singapore: how population genomics help guide clinical policy
AbstractHereditary Cancer makes up around 5 –10% of all cancers. It is important to diagnose hereditary cancer in a timely fashion, as not only do patients require long-term care from a young age, but their relatives also require management. The main approach to capture at-risk relatives is cascade testing. It involves genetic testing of re latives of the first detected carrier of a pathogenic variant in a family i.e. the proband. The current standard of care for cascade testing is a patient-mediated approach. Probands are then advised to inform and encourage family members to undergo genetic testing. In Singapore, casca...
Source: Familial Cancer - April 25, 2024 Category: Cancer & Oncology Source Type: research

Burden of Antimicrobial Resistance in Japan: A Systematic Literature Review and Meta-Analysis
ConclusionOur study presents an overview of the clinical and economic burden of AMR in Japan. Patients with AMR infections experience significantly higher in-hospital mortality, LOS, and direct medical costs compared with patients without AMR infections. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 25, 2024 Category: Infectious Diseases Source Type: research

Viruses, Vol. 16, Pages 667: Unveiling the Role of Human Papillomavirus in Urogenital Carcinogenesis a Comprehensive Review
n Human papillomavirus (HPV), an oncogenic DNA virus, is the most common sexually transmitted virus and significant public health concern globally. Despite the substantial prevalence of HPV infection among men, routine testing remains elusive due to the lack of approved HPV tests and the complexity of detection methods. Various studies have explored the link between HPV and genitourinary cancers, revealing different associations influenced by geographic variation, histological subtype and methodological differences. These findings underscore the importance of further research to elucidate the role of HPV in male urogen...
Source: Viruses - April 25, 2024 Category: Virology Authors: Beliz Bahar Karao ğlan Y üksel Ürün Tags: Review Source Type: research

World War I and the Thomas Splint: A Historical Review
Mil Med. 2024 Apr 24:usae108. doi: 10.1093/milmed/usae108. Online ahead of print.ABSTRACTThe Thomas splint, the first practical traction splint for femoral fractures, revolutionized the capabilities of military medicine. Its usage in WWI lowered the mortality rate from 80% to nearly 15%. Its development not only shaped modern orthopedics but also established the splint as standard equipment in hospitals worldwide.PMID:38656831 | DOI:10.1093/milmed/usae108 (Source: Military Medicine)
Source: Military Medicine - April 24, 2024 Category: International Medicine & Public Health Authors: Joseph R Danford Daniel J Stinner Source Type: research

Menthol and filter ventilation in cigarettes: prevalence estimates and relationships with harm perception and smoking exposure
CONCLUSION: The well-documented harm misperception linked to higher FV is more apparent in those using non-menthol than menthol cigarettes. Increased exposures were observed among some non-menthol cigarette users compared with some menthol cigarette users. These results should by no means delay a menthol ban but rather motivate concerted public health efforts to accompany the menthol ban to maximise smoking cessation.PMID:38658056 | DOI:10.1136/tc-2023-058495 (Source: Cancer Control)
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Dana Mowls Carroll Lorna Bittencourt Katelyn M Tessier Ayaantuu Usman Irina Stepanov Dorothy K Hatsukami Source Type: research

Pursuance of a Yoruba name for cervical cancer in Southwest Nigeria: a case study
CONCLUSIONS: There was no consensus Yoruba name for cervical cancer among the study participants. Efforts to educate the Yoruba speaking populace about cervical cancer, its prevention, management and participation in its research can be frustrated if a generally accepted Yoruba name is not provided for this cancer. Stakeholders' collaboration is required to get an appropriate Yoruba name for cervical cancer.PMID:38658005 | DOI:10.1136/bmjopen-2023-074020 (Source: Cancer Control)
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Folusho Mubowale Balogun Olayemi Omotade Source Type: research

Intestinal Parasitic Infections in People Referring to the Central Laboratory of Meshkin Shahr County, Ardabil Province, Iran
CONCLUSION: In- spite of betterment of the health condition in Iran and reduction of parasitic infection, intestinal parasitic infections are still a considerable public health issue in some parts of Iran.PMID:38654952 | PMC:PMC11033542 | DOI:10.18502/ijpa.v19i1.15217 (Source: Iranian Journal of Parasitology)
Source: Iranian Journal of Parasitology - April 24, 2024 Category: Parasitology Authors: Pooria Asadi Zabihollah Zarei Mehdi Mohebali Zahra Alizadeh Faezeh Najafi Shahrokh Izadi Zahra Heidari Source Type: research