Fight Aging! Newsletter, February 28th 2022
In conclusion, as BMI and waist circumference are related to elevations of immune markers in the IL-6 pathway, chronic inflammation might be an important mediator of the relationship between BMI and frailty.
Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter
https://www.fightaging.org/archives/2022/02/fat-tissue-becomes-dysfunctional-with-age-as-mitochondria-falter/
Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying r...
Source: Fight Aging! - February 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Stem Cell Therapies for Intervertebral Disc Degeneration
Stem cell therapies, and cell therapies in general, have tremendous promise in treating age-related conditions, particularly those that lead to structural damage in the body, such as degenerative disc disease. While animal studies have produced very interesting results, these therapies have yet to achieve more than initial goals in clinical practice, however. Hematopoietic stem cell transplants work well for the uses they are put to, albeit while being a comparatively stressful, higher risk procedure. Immunotherapies based on cell transplants are quite well advanced in the cancer field. First generation mesenchymal stem ce...
Source: Fight Aging! - February 22, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, February 21st 2022
In conclusion, clinical trials targeting aging in humans have shown promising but limited results on biomarkers so far.
Mycobacterium Vaccae Immunization as an Anti-Inflammatory Strategy
https://www.fightaging.org/archives/2022/02/mycobacterium-vaccae-immunization-as-an-anti-inflammatory-strategy/
In today's open access paper, researchers discuss immunization with Mycobacterium vaccae as an approach to reduce the inflammatory overactivity of the aged immune system. Researchers have made some initial inroads into studying the way in which this bacteria can alter the function of the immune system, and her...
Source: Fight Aging! - February 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Disaggregases as the Basis for Therapies to Remove Amyloids
A few proteins in the body are capable of misfolding or becoming otherwise altered in ways that encourage other molecules of the same protein to do the same. They can spread throughout a tissue and the body, given time, forming aggregates that precipitate into solid clumps and fibrils, surrounded by a halo of toxic biochemistry that harms cells. This is an age-related problem, likely because the systems of maintenance and recycling responsible for clearing aggregates falter with age, a victim of rising levels of molecular damage and the maladaptive reactions to that damage.
Amyloid-β, associated with Alzheimer's di...
Source: Fight Aging! - February 18, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
From Potatoes to Pharmaceuticals: Idaho INBRE Alumni ’s Diverse Careers
Jenny Durrin. Credit: University of Idaho.
Jenny Durrin says she would never have become the director of the Seed Potato Germplasm Program at the University of Idaho, Moscow, without the experience she gained through the Idaho IDeA Networks of Biomedical Research Excellence (INBRE) program. Another Idaho INBRE alum, Steve Van Horn, credits the program with enabling him to start a career in the pharmaceutical industry.
Providing undergraduate students with research opportunities and preparing them for STEM careers in biomedical sciences are key goals of INBREs across the country, including Idaho’s program. Here, we...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 16, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Training Source Type: blogs
Fight Aging! Newsletter, February 14th 2022
In conclusion, this first examination of the effects of age and the ageing process on the small intestinal microbiome demonstrates that the duodenal microbiome changes with increasing age, with significant decreases in duodenal microbial diversity due to increased prevalence of phylum Proteobacteria, particularly coliforms and anaerobic taxa. Given the key roles of small intestinal microbes in nutrient absorption and host metabolism, these changes may be clinically relevant for human health during the ageing process.
Naked Mole Rats Exhibit Minimal Cardiac Aging
https://www.fightaging.org/archives/2022/02/nake...
Source: Fight Aging! - February 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Early CAR-T Therapies Produced Long Term Remission in Some Cases
Much of what we'd like to know about cancer therapies takes a long time to emerge. Only now is the long term data available for the first CAR-T immunotherapies aimed at forms of leukemia in which cancerous cells are clearly and distinctly marked by characteristic surface features. The field has long since expanded, and researchers are at present trying to adjust CAR-T in order to apply this form of treatment to solid cancers. Long term remission is not the same as a cure, as cancer is a disease in which it remains challenging to say whether or not a few remnant cancer cells await a return at some future time. If one can ma...
Source: Fight Aging! - February 10, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Longevity.Technology Looks Back at 2021
A fair number of news and interest sites covering aging research and the development of therapies to treat aging as a medical condition have come and gone over the years. Longevity.Technology is one of the few that seems likely to stick around for a while, now that there is a growing longevity industry to cover, and thus the ability to bring in enough revenue in traditional ways to run a small professional journalism organization. The Longevity.Technology staff recently published a set of short retrospective articles, looking back on industry news from 2021; some are linked below.
The lie of the longevity landscape ...
Source: Fight Aging! - January 3, 2022 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Fight Aging! Newsletter, January 3rd 2022
In this study, we showed that the iPaD (inducing Plagl2 and anti-Dyrk1a) lentivirus substantially rejuvenated the proliferative and neurogenic potential of NSCs in the aged brain. Clonal analysis by a sparse labeling approach as well as transcriptome analysis indicated that iPaD can rejuvenate aged NSCs (19-21 mo of age) to a level comparable with those at 1 or 2 months of age and successfully improved cognition of aged mice.
Once rejuvenated and activated by iPaD, aged dormant NSCs can generate, on average, 4.9 neurons but very few astrocytes in 3-week tracing. Furthermore, these activated NSCs were maintained for ...
Source: Fight Aging! - January 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2021: Progress Towards the Treatment of Aging as a Medical Condition
Well, here we are again, at the end of another pandemic year, a year older and - hopefully - a year wiser and more knowledgeable. I said all that really needs to be said on the topic of COVID-19 as an age-related condition at the end of last year. We might hope that, given widespread vaccination, the pandemic will become a topic of diminishing importance as the year ahead progresses, even given the present round of variants, fears, and reintroduction of restrictions.
Advocacy for Aging Research
Have we finally made significant progress in convincing the world that aging is the cause of age-related disease, th...
Source: Fight Aging! - December 31, 2021 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Suppression of Inflammatory Signaling as a Treatment for Frailty
Age-related frailty is accompanied by marked chronic inflammation, and indeed much of the physical weakness of frailty is likely caused by long-term inflammation and the ways in which it disrupts muscle tissue maintenance. The tools presently available to suppress inflammation are somewhat blunt, interfering in the necessary signaling needed to maintain a normal immune response, as well as in the unwanted overactivation of the immune system found in older people. Nonetheless, such tools are slowly becoming better and more selective over time, and some are now being tested as treatments for frailty.
Earlier this ye...
Source: Fight Aging! - December 21, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 20th 2021
In conclusion, the low dose, prolonged angiotensin II exposure is associated with the induction of senescence in kidneys and the promotion of an inflammatory microenvironment through both secreted factors and immune cells. Endothelial cells appear to be a major cell type impacted. The elimination of senescent cells in the INK-ATTAC transgenic model prevents these effects of angiotensin II and reveals a novel pathophysiologic mechanism amenable to targeting by senolytic drugs in development.
CYTOR Upregulation as a Path to Improved Muscle Function in Later Life
https://www.fightaging.org/archives/2021/12/cytor-...
Source: Fight Aging! - December 19, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Possibility of Senolytic Vaccinations to Control the Burden of Senescent Cells
Arguably the primary reason why the number of senescent cells increases with age throughout the body is the growing failure of the immune system to clear these errant cells. The reasons for that failure are not well understood in detail, though some inroads have been made into that area of research. Both the innate and adaptive immune system are involved in clearance of senescent cells, so in principle there should be a plethora of mechanisms that could be targeted in order to create immunotherapies that increase the pace at which the immune system clears senescent cells. Both SIWA Therapeutics and Deciduous Therapeutics a...
Source: Fight Aging! - December 17, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
December 2021: Check Out Checkpoint Inhibitors
"Hey, can you check out this rash? It is all over," a nurse said to me."What can you tell me?""He has metastatic cancer. The rash started a couple days ago.""It's probably a checkpoint inhibitor rash. I'll check it out."Medicine has developed an entirely new approach to cancer since I went to medical school. Therapeutics were all about direct toxicity to rapidly dividing cells a few decades ago. Now we have an entirely new classification of treatment: immunotherapy.Immunotherapy tries to increase the body's ability to use its own defenses against cancer. One group of agents is...
Source: Lions and Tigers and Bears - December 1, 2021 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
