The Immune Response to Tumors Changes with Age
The interaction between the immune system and tumor is meaningfully different in young and old individuals. The aging of the immune system makes near everything worse in health and physiology. It greatly affects risk of cancer, in the sense of determining whether pre-cancerous cells are eliminated before they can gain a foothold. It also affects the distribution of cancer types, for reasons that are not fully explored. Further, and as discussed here, it affects the efforts of the immune system to destroy an established tumor.
Advanced age is strongly correlated with both increased cancer incidence and general immu...
Source: Fight Aging! - June 23, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 22nd 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 21, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Patch for Melanoma Treatment to Make Chemo Easier, Painless, More Effective
Scientists at Purdue University are reporting a skin patch that can deliver chemotherapy into melanoma tumors in an effective, convenient, and painless way. This may be an important development, as currently chemotherapy delivery options are limited and result in systemic exposure in the whole body and/or poor effectiveness.
Previous attempts at chemotherapy delivery via a patch required the use of large needles, which themselves dissolved way too fast once inside the skin to maintain continuous drug delivery. “We developed a novel wearable patch with fully miniaturized needles, enabling unobtrusive drug delivery thro...
Source: Medgadget - June 18, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Dermatology Materials Medicine Oncology Source Type: blogs
Retraining the Immune System to Turn Off Autoimmunity
This interesting study suggests that it may be possible to turn off many forms of autoimmunity by inducing tolerance, in a comparatively simple manner, to the specific fragment of a protein that is causing an immune reaction. There are autoimmunities in which the specific trigger is poorly understood, including the only vaguely cataloged and no doubt highly variable autoimmunities of aging, but many other conditions for which this might be a useful approach.
Autoimmune diseases are caused when the immune system loses its normal focus on fighting infections or disease within and instead begins to attack otherwise h...
Source: Fight Aging! - June 17, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Itchy, Bumpy Blues: How to Treat and Prevent Mosquito Bites and Related Conditions
Mosquito bites may be a nuisance, but fortunately, in the U.S., they tend to amount to nothing more than that. Upon being bitten, most Americans experience a bit of swelling and itchiness, and nothing more. However, there are exceptions to this, including stronger allergic reactions to bites and cases of mosquito-borne illness.
Insect and arachnid bites, including ticks, account for approximately 2,000 cases of malaria and 30,000 cases of Lyme disease in the U.S. annually. In addition, millions of people worldwide die of malaria each year. It is helpful to protect yourself against insect bites, not only to avoid pesk...
Source: Conversations with Dr Greene - June 7, 2020 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog Environmental Health Insect Bites & Stings Insects & Animals Outdoor Safety Source Type: blogs
Fight Aging! Newsletter, June 8th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - June 7, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Antibodies that Target Toxic Amyloid- β Oligomers
One possible expansion of present immunotherapies for Alzheimer's disease is to more specifically track and target oligomeric forms of amyloid-β. Efforts to reduce amyloid-β in the brain have, after many years of failure, started to succeed in that goal in human trials, but patients are not exhibiting benefits as a result. It remains to be seen whether or not this is because amyloid-β is a trigger for other self-sustaining pathological mechanisms, such as cellular senescence of supporting cells in the brain, and thus removing it does little good once Alzheimer's is underway. An alternative view is that perhaps the wrong...
Source: Fight Aging! - June 2, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 18th 2020
This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function.
On Nutraceutical Senolytics
https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/
Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therap...
Source: Fight Aging! - May 17, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Advocating for Senolytics to Prevent Accelerated Aging Resulting from Cancer Treatment
Chemotherapy and radiotherapy remain the presently dominant forms of cancer treatment. Immunotherapies are making slow inroads, but remain a minority of all treatments. Both chemotherapy and radiotherapy kill cells and force cells into senescence, cancerous cells and otherwise. They are a balance struck between killing the cancer and killing healthy tissue, and are are not pleasant at all for the patient. Cancer survivors have a significantly reduced life expectancy, as large as that resulting from life-long smoking, and evidence strongly suggests that this is due to a significantly increased burden of>senescent cells left...
Source: Fight Aging! - May 11, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Predicting the Future by Listening to the Experts
Stephanie Kuku
Hugh Harvey
By STEPHANIE KUKU, MD and HUGH HARVEY, MBBS
The ability to predict in healthcare is the utopia promised by every artificial intelligence for healthcare built, funded and tested in the last decade. Yet very few doctors, technologists, or investors would have imagined they would live to witness a pandemic of the scale we are currently experiencing. We are still getting our heads round the lives lost, the lives of the frontline workers at risk, the disruption and self-isolation, the less fortunate who will suffer the most, the companies in survival mode, and a battered global economy. ...
Source: The Health Care Blog - May 4, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Health Technology Hardian Health Hugh Harvey Stephanie Kuku Source Type: blogs
Fight Aging! Newsletter, April 27th 2020
In conclusion, our study demonstrated that Nrf2 deficiency promoted the increasing trend of autophagy during aging in skeletal muscle. Nrf2 deficiency and increasing age may cause excessive autophagy in skeletal muscle, which can be a potential mechanism for the development of sarcopenia.
To What Degree is Chondrocyte Hypertrophy in Osteoarthritis Due to Cellular Senescence?
https://www.fightaging.org/archives/2020/04/to-what-degree-is-chondrocyte-hypertrophy-in-osteoarthritis-due-to-cellular-senescence/
Senescent cells are large. They do not replicate, that function is disabled, but it is as if they go...
Source: Fight Aging! - April 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Alzheimer's Therapies are Achieving Goals in Patient Biochemistry, But Not in Outcomes
If a therapy targets an important cause of a condition, and does so effectively, there should be little ambiguity in the results that emerge from clinical trials. The size of effect will be large, there will be no need to frown and interpret and try to find subgroups in the which the results are enough to declare some sort of success. Sadly, this latter position is much the state of the Alzheimer's clinical development community, still largely focused on immunotherapies targeting amyloid-β. Such an enormous amount of funding is devoted to these efforts that there is considerable incentive for the sponsoring entities to fi...
Source: Fight Aging! - April 21, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, April 20th 2020
In conclusion, elevated brain amyloid was associated with family history and APOE ε4 allele but not with multiple other previously reported risk factors for AD. Elevated amyloid was associated with lower test performance results and increased reports of subtle recent declines in daily cognitive function. These results support the hypothesis that elevated amyloid represents an early stage in the Alzheimer's continuum.
Blood Metabolites as a Marker of Frailty
https://www.fightaging.org/archives/2020/04/blood-metabolites-as-a-marker-of-frailty/
Frailty in older people is usually diagnosed in a symptomatic...
Source: Fight Aging! - April 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Elevated Brain Amyloid- β Levels Correlate with Worse Cognitive Performance in Clinically Normal Old People
In conclusion, elevated brain amyloid was associated with family history and APOE ε4 allele but not with multiple other previously reported risk factors for AD. Elevated amyloid was associated with lower test performance results and increased reports of subtle recent declines in daily cognitive function. These results support the hypothesis that elevated amyloid represents an early stage in the Alzheimer's continuum.
Link: https://doi.org/10.1001/jamaneurol.2020.0387 (Source: Fight Aging!)
Source: Fight Aging! - April 13, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 6th 2020
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted.
Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - April 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
