Fight Aging! Newsletter, May 18th 2020

This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function. On Nutraceutical Senolytics https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/ Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therapeutic effect. Unfortunately, in practice the nutraceutical industry is a largely a lazy one, in which entrepreneurs take advantage of a short path to market, and a lack of interest among consumers in whether or not products actually work, in order to repackage cheap ingredients into expensive brands that have minimal, unreliable, or even no beneficial effects. In today's open access paper, researchers discuss the potential for nutraceutical research and development to produce useful senolytic compounds. A senolytic therapy is one that selectively kills senescent cells in aged tissues, thus reversing aspects of aging by removing the inflammatory, harmful signaling of these cells. This class of therapy has performed well in animal models, and early human trials continue to produce promising outcomes. Any survey of nutraceutical development is, as ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Publication date: Available online 13 July 2020Source: Journal of the American College of RadiologyAuthor(s): Mourão Rodrigo, Correa Diogo, Ventura Nina, Pereira Ronaldo
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
ConclusionWe achieved promising results with this computer-aided diagnosis method that we tried to develop using convolutional neural networks based on transfer learning. This method can help clinicians for the diagnosis of hip osteoarthritis while interpreting plain pelvic radiographs, also provides assistance for a second objective interpretation. It may also reduce the need for advanced imaging methods in the diagnosis of hip osteoarthritis.
Source: Skeletal Radiology - Category: Radiology Source Type: research
AbstractCalcific tendinopathy typically affects the shoulder rotator cuff tendons. Its management includes shock wave therapy and US-guided percutaneous irrigation, with surgery being less and less used. Extra-shoulder calcific tendinopathy is relatively infrequent and typically affects the hip. While the diagnostic techniques and the treatment options for shoulder calcific tendinopathy have been extensively described, there are only anecdotic reports on the other sites. In this paper, we have reported an unusual case of non-insertional Achilles calcific tendinopathy which occurred many years after Achilles surgical repair...
Source: Skeletal Radiology - Category: Radiology Source Type: research
AbstractObjectiveTo investigate the associations of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with changes in knee cartilage composition and joint structure over 48  months, using magnetic resonance imaging (MRI) data from the Osteoarthritis Initiative (OAI).Materials and methodsA total of 1126 participants with right knee Kellgren-Lawrence (KL) score 0 –2 at baseline, no history of rheumatoid arthritis, blood pressure measurements at baseline, and cartilage T2 measurements at baseline and 48 months were selected from the OAI. Cartilage composition was assessed using MRI T2 measuremen...
Source: Skeletal Radiology - Category: Radiology Source Type: research
Authors: Martín Enguix D, Salazar Nievas MDC, Martín Romero DT PMID: 32654832 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Authors: Aparisi Á, Uribarri A Abstract Takotsubo syndrome is an acute cardiomyopathy that mimics acute coronary syndrome and is characterized by acute heart failure with reversible ventricular motion abnormalities, in the absence of justifying coronary artery disease. This document offers an exhaustive review of various proposed hypotheses that attempt to explain the pathophysiology of this disease and provides an updated review of the different classifications that have emerged in recent years. In addition, we describe the main clinical characteristics of these patients, the diagnostic tests that must be p...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
An imaging technique that combines F-18 FDG PET and MRI was able to pinpoint...Read more on AuntMinnie.comRelated Reading: SNMMI 2020: How nuclear medicine handled COVID-19 SNMMI 2020: Medical students key to the specialty's future PET, MRI uncover women's predisposition to Alzheimer's PET/MRI shows inflammation link to mitral valve prolapse Biomarkers on PET, MRI show breast cancer risk
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: Available online 20 June 2020Source: The Journal of Molecular DiagnosticsAuthor(s): Lynette M. Sholl, Diana Mandelker, Tracy Stockley
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Jie Zhang, Sujie Zhang, Xiaoyan Li, Fan Zhang, Lei Zhao
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Xianglin Yang, Xuelian Li, Xia Hao, Wen Tian, Baosen Zhou
Source: Pathology Research and Practice - Category: Pathology Source Type: research
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