Elevated Brain Amyloid- β Levels Correlate with Worse Cognitive Performance in Clinically Normal Old People

In conclusion, elevated brain amyloid was associated with family history and APOE ε4 allele but not with multiple other previously reported risk factors for AD. Elevated amyloid was associated with lower test performance results and increased reports of subtle recent declines in daily cognitive function. These results support the hypothesis that elevated amyloid represents an early stage in the Alzheimer's continuum. Link: https://doi.org/10.1001/jamaneurol.2020.0387
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