Fight Aging! Newsletter, April 15th 2019
In this study, we found that senescent chondrocytes isolated from OA patients secrete more EVs compared with nonsenescent chondrocytes. These EVs inhibit cartilage ECM deposition by healthy chondrocytes and can induce a senescent state in nearby cells. We profiled the miR and protein content of EVs isolated from the synovial fluid of OA joints from mice with SnCs. After treatment with a molecule to remove SnCs, termed a senolytic, the composition of EV-associated miR and protein was markedly altered. The senolytic reduced OA development and enhanced chondrogenesis, and these were attributable to several specific differenti...
Source: Fight Aging! - April 14, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Aubrey de Grey on the Dawn of the Era of Human Rejuvenation
In this interview, Aubrey de Grey of the SENS Research Foundation discusses the present state of rejuvenation biotechnology. The first rejuvenation therapies now exist, these being the various methods of selectively removing senescent cells that de Grey and others called for back in 2002. The world is finally catching up to the vision of rejuvenation therapies that our community has advocated for more than fifteen years. Now that we are finally here, there is, if anything, even more work to be accomplished than was the case in past years. The funding for clinical development exists, but it is still true that many lines of ...
Source: Fight Aging! - April 9, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Our Visit to WIRED Health 2019 at London ’s Francis Crick Institute
WIRED Health, now in its sixth year, returned to London’s Francis Crick Institute. The event was opened by Crick Institute director Paul Nurse who introduced the institute and its mission to understand the fundamental biology of human health and disease. The team at the Crick, consisting of 1500 researchers and three Nobel Prize winners, make up Europe’s largest biomedical research facility with an already impressive slate of research, despite being only two years old. The theme of WIRED Heath and the venue’s vision was perfectly summarized by Sir Paul, who closed his address with the charge “from this crucible th...
Source: Medgadget - April 2, 2019 Category: Medical Devices Authors: Tom Peach Tags: Exclusive Medicine Public Health Society Source Type: blogs
Fight Aging! Newsletter, April 1st 2019
In conclusion, long-term aerobic exercise appears to attenuate the decline in endothelial vascular function, a benefit which is maintained during chronological aging. However, currently there is not enough evidence to suggest that exercise interventions improve vascular function in previously sedentary healthy older adults.
Hijacking the Proteasome to Dispose of Unwanted Molecules in Age-Related Disease
https://www.fightaging.org/archives/2019/03/hijacking-the-proteasome-to-dispose-of-unwanted-molecules-in-age-related-disease/
Cells are equipped with a protein disposal system in the form of the proteas...
Source: Fight Aging! - March 31, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Last Couple of Months in Oncology with Dr. Bishal Gyawali: March 2019
By BISHAL GYAWALI MD, PhD
Hey, I’m back!
Well, you might not have noticed that my blogs were missing for the last three months but anyways, its good to be back. I was having a little time off blogs and social media as I was transitioning in my career but now I am back. Sometimes, it is very difficult to manage time for things that you must do versus things you enjoy doing, especially when these two don’t intersect. For me, these last few months the things I had to do were all bureaucratic while I couldn’t find the time for things I enjoy doing like writing these blogs. But now that we are back, let’s rec...
Source: The Health Care Blog - March 26, 2019 Category: Consumer Health News Authors: Matthew Holt Tags: Medical Practice Physicians Bishal Gyawali Cancer drugs Clinical Trials Oncology Prostate Cancer RCTs Source Type: blogs
