Fight Aging! Newsletter, April 1st 2019

In conclusion, long-term aerobic exercise appears to attenuate the decline in endothelial vascular function, a benefit which is maintained during chronological aging. However, currently there is not enough evidence to suggest that exercise interventions improve vascular function in previously sedentary healthy older adults. Hijacking the Proteasome to Dispose of Unwanted Molecules in Age-Related Disease https://www.fightaging.org/archives/2019/03/hijacking-the-proteasome-to-dispose-of-unwanted-molecules-in-age-related-disease/ Cells are equipped with a protein disposal system in the form of the proteasome. Damaged or excess proteins are tagged with ubiquitin, and shuttled to the proteasome where they are dismantled into component parts that can be reused to build new proteins. The popular science article noted here discusses an approach to interfacing with this cellular maintenance system that is presently under developement, delivering carefully designed molecules that ensure a specific protein is tagged with ubiquitin, thus persuading the cell to destroy it. Over the course of aging, cells become exposed to any number of unwanted forms of molecular waste, many of which are proteins of one sort or another, and it is possible that finding ways to deliver those molecules to the proteasome could prove to be an effective therapy. The drug strategy, called targeted protein degradation, capitalizes on the cell's natural system for clearing unwanted or ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Publication date: Available online 22 October 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Shradhanjali Singh, Shanti Bhushan Mishra, Alok MukerjeeAbstractThe plant Clerodendrum serratum (L.) Moon has been traditionally claimed for the treatment of various inflammatory conditions including rheumatoid arthritis, hence in the present study the effect of the crude ethanolic extract (CSEE) from leaves of the plant and its chloroform fraction (CSCF) were evaluated in acute and chronic arthritic model. Preliminary phytochemical screening was performed for CSEE and chloroform fraction (CSCF). Formaldehyde (2%...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 23 October 2019Source: Molecular and Cellular ProbesAuthor(s): Yi ChenAbstractCyclooxygenase-2 (COX-2) is an inducible enzyme that plays a key role in the inflammatory cascade through the generation of prostaglandins. Recent studies have found that COX-2 is closely related to the occurrence and development of tumors, angiogenesis and metastasis of tumors. Overexpressed COX-2 has become a predictive biomarker for progression of pre-malignant towards cancer in some tissues, which makes the detection of COX-2 of great value and clinical significance. This review highlights COX-2-specific flu...
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
Publication date: Available online 22 October 2019Source: Journal of Molecular BiologyAuthor(s): Owen Conway, Hafize Aysin Akpinar, Vladimir Rogov, Vladimir KirkinAbstractNeurons are electrically excitable, post-mitotic cells that perform sensory, relaying, and motor functions. Because of their unique morphological and functional specialization, cells of this type are sensitive to the stress caused by accumulation of misfolded proteins or damaged organelles. Autophagy is the fundamental mechanism that ensures sequestration of cytosolic material and its subsequent degradation in lysosomes of eukaryotic cells, thereby provid...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 23 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): V. Arroyo-Jousse, A. Jaramillo, E. Castaño-Moreno, M. Lépez, K. Carrasco-Negüe, P. CasanelloAbstractMaternal pregestational obesity is a well-known risk factor for offspring obesity, metabolic syndrome, cardiovascular disease and type 2 diabetes. The mechanisms by which maternal obesity can induce alterations in fetal and later neonatal metabolism are not fully elucidated due to its complexity and multifactorial causes. Two adipokines, leptin and adiponectin, are involved i...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Publication date: Available online 22 October 2019Source: Saudi Journal of Biological SciencesAuthor(s): Mohammad I. Al-Obaida, Alaa K.M. Al-Nakhli, Ibrahim A. Arif, Asmaa Faden, Sahar Al-Otaibi, Bushra Al-Eid, Aishah Ekhzaimy, Haseeb A. KhanAbstractPeriodontal disease is a chronic infectious disease, which is characterized by the damaged dental hard tissue by lactic acid generated by microorganisms after the fermentation of carbohydrates rich diet. The risk of periodontal disease is known to be higher in diabetic patients. We compared the diversity of five commonly occurring dental bacteria including Porphyromonas gingiva...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: Available online 22 October 2019Source: Redox BiologyAuthor(s): Ziwei Wang, M. Corina Litterio, Michael Müller, David Vauzour, Patricia I. OteizaAbstractSecondary bile acids promote gastrointestinal (GI) tract permeabilization both in vivo and in vitro. Consumption of high fat diet s increases bile acid levels in the GI tract which can contribute to intestinal permeabilization and consequent local and systemic inflammation. This work investigated the mechanisms involved in bile acid (deoxycholic acid (DCA))-induced intestinal epithelial cell monolayer permeabilization and the preventive capacity of (...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: Available online 22 October 2019Source: Life SciencesAuthor(s): Li Lei, Meng Li, Yiqun Pang, Jun Wang, Yunpeng Wan, Chen Zhu, Yin ZongshengAbstractAimsPrevious study indicated that the increase of local bio-availability of 3′3′5-triiodothyronine (T3) influenced osteoarthritis (OA) initiation. We aimed to investigate the role of thyroid hormone receptors (THRs) signaling in OA osteoblasts.Materials and methodsTHRs expression in OA was detected by immunohistochemistry, immunofluorescence, RT-qPCR and western blotting. These effects on the expression of angiogenesis-related factors were examined ...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 22 October 2019Source: Life SciencesAuthor(s): Hira Butt, Azra Mehmood, Muhammad Ali, Saba Tasneem, Moazzam N. Tarar, Sheikh RiazuddinAbstractAimsThermal burns are the most common type of skin injuries. Clinically, the deteriorating thermal wounds have been successfully treated with skin cell sheets, suspensions or bioengineered skin substitutes. After thermal injury, oxidative microenvironment prevalent in the burnt tissue due to imbalance between production of free radicals and antioxidants defense aiding to destruction of cellular or tissue components. However, depleted antioxidant con...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 22 October 2019Source: Life SciencesAuthor(s): Pollyana S. Siqueira-Lima, Jullyana S.S. Quintans, Luana Heimfarth, Fabiolla R.S. Passos, Erik W.M. Pereira, Marilia M. Rezende, José E.R. Menezes-Filho, Rosana S.S. Barreto, Henrique D.M. Coutinho, Adriano A.S. Araújo, Aline S. Medrado, Ligia A. Naves, Horácio F. Bomfim, Angélica M. Lucchese, Sathiyabama Rajiv Gandhi, Lucindo J. Quintans-JúniorAbstractNeuropathic pain (NP) is a difficult condition to treat because of the modest efficacy of available drugs. New treatments are required. In the study we aimed ...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 22 October 2019Source: Carbohydrate PolymersAuthor(s): Madhusudhan Alle, Bhagavanth Reddy G, Tae Hoon Kim, Seok Ho Park, Seoung Hwan Lee, Jin-Chul KimAbstractAn ultrafast (e.g. 75 sec) synthesis of carboxymethyl xanthan gum (CMXG) capped gold nanoparticles (AuNPs) (CMXG@AuNPs) was developed using microwave irradiation (MWI) method. The synthesis of AuNPs was optimized by varying CMXG amount, gold ion concentration, and MWI time. The CMXG@AuNPs exhibited a spherical shape, high crystallinity, and narrow size distribution (i.e. 8-10 nm). The electrostatic interaction-mediated ...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
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