Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed.
The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Viral Infection in Middle Age Correlates with Later Dementia Risk
A range of evidence suggests that persistent viral infection contributes to the risk of suffering neurodegenerative conditions such as Alzheimer's disease. This may be due to mechanisms relating to amyloid-β accumulation, in its role as an anti-microbial peptide, a part of the innate immune system. It may have more to do with lasting chronic inflammation subsequent to infection. Researchers here note another addition to the epidemiological data on this topic, in this case linking severe infections requiring hospitalization with later dementia risk. The effect sizes here are large and last for a long time following infecti...
Source: Fight Aging! - February 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 3rd 2022
In conclusion, based on the analysis of proteomics and transcriptome, we identified four SRMs that may affect aging and speculated their possible mechanisms, which provides a new target for preventing aging, especially skin aging.
A Popular Science Article on the State of Epigenetic Clocks
https://www.fightaging.org/archives/2022/09/a-popular-science-article-on-the-state-of-epigenetic-clocks/
This popular science article is a good view of the present state of development and use of epigenetic clocks, covering the issues as well as the promise. Epigenetic age can be measured, with many different clocks...
Source: Fight Aging! - October 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Mechanism by Which Herpesvirus May Accelerate Amyloid- β Aggregation Leading to Alzheimer's Disease
There is some debate over whether persistent viral infection, such as by herpesvirus, contributes meaningfully to the onset and development of Alzheimer's disease. It would be a convenient explanation, given that many people with all of the lifestyle risk factors for neurodegeneration, such as being overweight and sedentary, do not in fact go on to develop Alzheimer's. The epidemiology is mixed, however, with some studies suggesting yes, some no. Some of the positive data suggests that use of antiviral drugs lowers the risk of Alzheimer's. More recent work argues that multiple different viral infections are required for a ...
Source: Fight Aging! - September 29, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
September 22, 2022 Edition-----We will see the closure on the Mourning Period for QE!! In Australia tomorrow, We can then move on to the next big issue, which will surely be the progress in the Russo-Ukrainian war and the associated issues with China and Russia.The US seems – with the rest of the world – to be moving into recession.King Charles has now been to all his UK Realms and will now quietly let PM Trass get back to running the UK. God help her …In Australia we have to now get on with life and the economic disaster we seem to be facing.-----Major Issues.-----https://www.afr.com/politics/federal/oddly-enough-th...
Source: Australian Health Information Technology - September 22, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Fight Aging! Newsletter, September 12th 2022
Discussion of Present Drug Development to Target Senescent Cells
Targeting Senescent Cells to Better Address Cancer and Consequences of Cancer Therapy
Calorie Restriction Suppresses Generation of Immune Cells via Changes to the Gut Microbiome
Arguing for an Expansion of the Hallmarks of Aging
https://www.fightaging.org/archives/2022/09/arguing-for-an-expansion-of-the-hallmarks-of-aging/
The hallmarks of aging form a catalog of largely better studied changes in cells and tissues considered relevant, and possibly more important, in the onset and development of age-related degeneration and disease. Thi...
Source: Fight Aging! - September 11, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More Evidence Against Herpesvirus Infection as a Meaningful Contribution to Alzheimer's Disease
There is a continuing debate over the role of persistent viral infection in the development of neurodegenerative disease. It seems plausible that such infection could increase chronic inflammation, and inflammation in brain tissue is a hallmark of neurodegenerative conditions. Just because the mechanism exists doesn't mean it is the primary, or even important, component of the disease process however. This is ever the challenge in complex age-related diseases, determining which of the many mechanisms in play are in fact those that primarily cause the condition. So there is a back and forth of epidemiological studies in rec...
Source: Fight Aging! - September 5, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 8th 2022
In conclusion, aging research will benefit from a better definition of how specific regulators map onto age-dependent change, considered on a phenotype-by-phenotype basis. Resolving some of these key questions will shed more light on how tractable (or intractable) the biology of aging is.
Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes?
https://www.fightaging.org/archives/2022/08/does-acarbose-extend-life-in-short-lived-species-via-gut-microbiome-changes/
Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a...
Source: Fight Aging! - August 7, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Continuing the Debate Over Viral Contributions to Alzheimer's Disease
Persistent viral infection may be an important contributing cause of Alzheimer's disease, either because the amyloid-β associated with Alzheimer's disease is a part of the innate immune response, and infection thereby increases production, or because persistent infection drives the chronic inflammation that disrupts the biochemistry of brain tissue. If viral infection does drive Alzheimer's disease, it may go some way towards explaining why the disease doesn't correlate with lifestyle factors such as weight, activity, and so forth, anywhere near as well as is the case for other common age-related conditions. It all sounds...
Source: Fight Aging! - August 5, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 23rd 2022
In conclusion, remofuscin activates the lysosome-to-nucleus pathway in C. elegans, thereby increasing the expression levels of xenobiotic detoxification genes resulted in extending their lifespan.
Naked Mole-Rat Skin Shows Fewer Signs of Aging
https://www.fightaging.org/archives/2022/05/naked-mole-rat-skin-shows-fewer-signs-of-aging/
Naked mole-rats exhibit a maximum life span that is many times longer than is the case for similarly sized mammals. Further, they are negligibly senescent, showing few age-related declines in function across much of that lengthy life span. That includes maintenance of stem ...
Source: Fight Aging! - May 22, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Pathogenic Viruses Have Evolved to Provoke Cellular Senescence
We present a "decentralized" information processing model that conceptualizes neurodegeneration as a systemic illness, triggered by cytoskeletal pathology. We also discuss strategies for reversing cell-cell fusion, including, TMEM16F inhibitors, calcium channel blockers, senolytics, and tubulin stabilizing agents. Finally, going beyond neurodegeneration, we examine the potential benefit of harnessing fusion as a therapeutic strategy in regenerative medicine.
Link: https://doi.org/10.3389/fcimb.2022.845580 (Source: Fight Aging!)
Source: Fight Aging! - May 17, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Kissing disease ’s link to multiple sclerosis
In recent decades, mounting evidence has suggested the Epstein-Barr virus (EBV), a ubiquitous member of the herpes family that causes infectious mononucleosis (a.k.a. the“kissing disease”), can cause multiple sclerosis (MS). Last month, a study published in the journal Science went even further, citing EBV infection as likely the leading cause of MS. It isRead more …Kissing disease’s link to multiple sclerosis originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 21, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/hoag-memorial-hospital-presbyterian" rel="tag" > Hoag Memorial Hospital Presbyterian < /a > < /span > Tags: Conditions Infectious Disease Source Type: blogs
Congenital cytomegalovirus infection : CT Scan
History :1 month neonate c/o convulsionsFindings:CT brain shows ventricular dilatationPeriventricular calcification is seen around both the lateral ventriclesDiagnosis:The findings are typical of congenital cytomegalovirus infectionExtra Edge InformationWhat is TORCH infection?Toxoplasma, Rubella, Cytomegalovirus and herpes infection that typically affects newborn. Types of calcification as clue to diagnosis?CMV – Periventricular, Toxoplasma – basal gangliaOther features of CMV infection?Hepatosplenomegaly, chorioretinitisFamous Radiology Blog by Dr Sumer Sethi www.sumersethi.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - February 14, 2022 Category: Radiology Authors: Sumer Sethi Source Type: blogs
What's new in midwifery - 5th January 2022
My calendar is reminding me it is time for What ' s New, so even though I only did it yesterday, here it is. I plan to be more regular in 2022 with this series of posts.Department of Health and Social Care Policy Paper:Our vision for the women ' s health strategy for England(Thanks to the King ' s Fund Library Health Management and Policy Alert for that).In the newsInquest to be held into the deaths of two mothers who contracted herpes during caesarean sectionsBreastfeeding voyeurism proposed as new offence in England and WalesWoman has baby with " birth dog " at her sideHeadline a little misleading, I think - t...
Source: Browsing - January 5, 2022 Category: Databases & Libraries Tags: midwifery Source Type: blogs
Fight Aging! Newsletter, August 23rd 2021
In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. We examined prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer, finding two generalized patterns.
First, IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy; younger individuals with high IGF-1 are protected from disease, while older individuals with high IGF-1 are at increased risk for incident disease or death. Second, the association between IGF-1 and risk ...
Source: Fight Aging! - August 22, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
